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Mblk ‐1 regulates sugar responsiveness in honey bee (Apis mellifera) foragers
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Source: Insect Science - September 28, 2021 Category: Biology Authors: Fang Liu, Lixian Wu, Yuan Zhang, Qiang Li, Liangbin Li, Zachary Y. Huang, Hongxia Zhao Tags: ORIGINAL ARTICLE Source Type: research

Upregulation of RasGRF1 ameliorates spatial cognitive dysfunction in mice after chronic cerebral hypoperfusion
In this study, we aimed to determine whether changes in the expression of RasGRF1, an important protein associated with cognition and synaptic plasticity, underlie the associated impairments in cognition after CCH. We found that RasGRF1 levels markedly decreased following CCH. Through prediction and validation studies, we observed that miRNA-323-3p was upregulated after CCH and could bind to the 3'-untranslated region of Rasgrf1 mRNA and regulate its expression in vitro. Moreover, the inhibition of miRNA-323-3p upregulated Rasgrf1 expression in the hippocampus after CCH, which was reversed by Rasgrf1 siRNA. This suggests t...
Source: Aging - April 13, 2023 Category: Biomedical Science Authors: Li-Jie Yang Wei Wu Wan-Rong Jiang Cheng-Liang Zhu Zhao-Hui Yao Source Type: research