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Total 203 results found since Jan 2013.

High- versus moderate-intensity aerobic exercise training effects on skeletal muscle of infarcted rats
Poor skeletal muscle performance was shown to strongly predict mortality and long-term prognosis in a variety of diseases, including heart failure (HF). Despite the known benefits of aerobic exercise training (AET) in improving the skeletal muscle phenotype in HF, the optimal exercise intensity to elicit maximal outcomes is still under debate. Therefore, the aim of the present study was to compare the effects of high-intensity AET with those of a moderate-intensity protocol on skeletal muscle of infarcted rats. Wistar rats underwent myocardial infarction (MI) or sham surgery. MI groups were submitted either to an untrained...
Source: Journal of Applied Physiology - April 15, 2013 Category: Physiology Authors: Moreira, J. B. N., Bechara, L. R. G., Bozi, L. H. M., Jannig, P. R., Monteiro, A. W. A., Dourado, P. M., Wisloff, U., Brum, P. C. Tags: ARTICLES Source Type: research

Simvastatin Impairs Exercise Training Adaptations
This study sought to determine if simvastatin impairs exercise training adaptations.Background: Statins are commonly prescribed in combination with therapeutic lifestyle changes, including exercise, to reduce cardiovascular disease risk in patients with metabolic syndrome. Statin use has been linked to skeletal muscle myopathy and impaired mitochondrial function, but it is unclear whether statin use alters adaptations to exercise training.Methods: This study examined the effects of simvastatin on changes in cardiorespiratory fitness and skeletal muscle mitochondrial content in response to aerobic exercise training. Sedenta...
Source: Journal of the American College of Cardiology - April 12, 2013 Category: Cardiology Authors: Catherine R. Mikus, Leryn J. Boyle, Sarah J. Borengasser, Douglas J. Oberlin, Scott P. Naples, Justin Fletcher, Grace M. Meers, Meghan Ruebel, M. Harold Laughlin, Kevin C. Dellsperger, Paul J. Fadel, John P. Thyfault Tags: Statin Treatment Source Type: research

Exercise training prevents skeletal muscle damage in an experimental sepsis model
CONCLUSION: In summary, aerobic physical preconditioning prevents atrophy, lipid peroxidation and protein oxidation and improves superoxide dismutase activity in the skeletal muscles of septic rats.
Source: Clinics - February 19, 2013 Category: Journals (General) Source Type: research

The platelet volume in patients with cardiac syndrome X
CONCLUSION: In summary, aerobic physical preconditioning prevents atrophy, lipid peroxidation and protein oxidation and improves superoxide dismutase activity in the skeletal muscles of septic rats.
Source: Clinics - February 19, 2013 Category: Journals (General) Source Type: research

Authors' comments on: The platelet volume in patients with cardiac syndrome X
CONCLUSION: In summary, aerobic physical preconditioning prevents atrophy, lipid peroxidation and protein oxidation and improves superoxide dismutase activity in the skeletal muscles of septic rats.
Source: Clinics - February 19, 2013 Category: Journals (General) Source Type: research

Differences in the mechanisms that induce obesity and metabolic syndrome in experimental animal models and humans may cause treatment failure
CONCLUSION: In summary, aerobic physical preconditioning prevents atrophy, lipid peroxidation and protein oxidation and improves superoxide dismutase activity in the skeletal muscles of septic rats.
Source: Clinics - February 19, 2013 Category: Journals (General) Source Type: research

Prediction of hospital events based on the severity of illness
CONCLUSION: In summary, aerobic physical preconditioning prevents atrophy, lipid peroxidation and protein oxidation and improves superoxide dismutase activity in the skeletal muscles of septic rats.
Source: Clinics - February 19, 2013 Category: Journals (General) Source Type: research

Effect of rehabilitative exercise training on peripheral muscle remodelling in patients with COPD: Targeting beyond the lungs.
Abstract Locomotor muscle dysfunction and weakness are frequently observed in patients with Chronic Obstructive Pulmonary Disease (COPD). In addition to intolerable sensations of dyspnoea which importantly contribute to exercise limitation, intrinsic muscle abnormalities have also been implicated in inducing leg muscle fatigue/discomfort during exercise in these patients. It is, however, uncertain whether these intrinsic muscle abnormalities are linked to a specific 'myopathy' or they constitute a consequence of the disease. Besides muscle disuse, other factors which may contribute to peripheral muscle dysfunction...
Source: Current Drug Targets - December 17, 2012 Category: Drugs & Pharmacology Authors: Nasis I, Kortianou EA, Clini E, Koulouris NG, Vogiatzis I Tags: Curr Drug Targets Source Type: research