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Why the U.S. Doesn ’t Have a Nasal Vaccine for COVID-19
The U.S. led the world in quickly developing COVID-19 vaccines—one of the few bright spots in the country’s otherwise criticized response. But while injectable vaccines are effective in protecting people from getting sick with COVID-19, they are less able to block infection. In order to put the pandemic behind us, the world will need a way to stop infections and spread of the virus. That’s where a different type of vaccine, one that works at the places where the virus gets into the body, will likely prove useful. Here, though, the U.S. is losing its edge. In September, India approved a nasal COVID-19 vacc...
Source: TIME: Health - October 31, 2022 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 healthscienceclimate Source Type: news

U.S. Health Officials Question AstraZeneca Vaccine Trial Results
According to federal officials, an independent panel of medical experts said the encouraging results announced on Monday might have relied on outdated information.
Source: NYT Health - March 24, 2021 Category: Consumer Health News Authors: Rebecca Robbins, Noah Weiland, Sharon LaFraniere and Benjamin Mueller Tags: Clinical Trials Drugs (Pharmaceuticals) Coronavirus (2019-nCoV) Vaccination and Immunization AstraZeneca PLC Food and Drug Administration National Institute of Allergy and Infectious Diseases Oxford University Source Type: news

Remdesivir and systemic corticosteroids for the treatment of COVID-19: A Bayesian re-analysis
The public health crisis caused by coronavirus disease 2019 (COVID-19) has led to unparalleled international scientific collaboration to find a safe and effective treatment, particularly for hospitalized patients. With close to 2 million deaths, treatments that can reduce mortality are needed urgently. Large multi-centre clinical trials are underway, led by groups such as the US National Institutes of Allergy and Infectious Diseases (Adaptive COVID-19 Treatment Trial), the University of Oxford's Nuffield Department of Population Health (RECOVERY trial) and the World Health Organization (WHO) and participating countries (SOLIDARITY trial).
Source: International Journal of Infectious Diseases - February 1, 2021 Category: Infectious Diseases Authors: Todd C. Lee, Emily G. McDonald, Guillaume Butler-Laporte, Luke B. Harrison, Matthew P. Cheng, James M. Brophy Source Type: research

mRNA Technology Gave Us the First COVID-19 Vaccines. It Could Also Upend the Drug Industry
“No!” The doctor snapped. “Look at me!” I had been staring her in the eyes, as she had ordered, but when a doctor on my other side began jabbing me with a needle, I started to turn my head. “Don’t look at it,” the first doctor said. I obeyed. This was in early August in New Orleans, where I had signed up to be a participant in the clinical trial for the Pfizer-BioNTech COVID-19 vaccine. It was a blind study, which meant I was not supposed to know whether I had gotten the placebo or the real vaccine. I asked the doctor if I would really been able to tell by looking at the syringe. &...
Source: TIME: Health - January 11, 2021 Category: Consumer Health News Authors: Walter Isaacson Tags: Uncategorized COVID-19 feature Magazine Source Type: news

COVID-19 Vaccines Are Coming. Here ’s What to Expect
Vaccines normally take decades to develop and test, but two COVID-19 shots, from Moderna and Pfizer (in partnership with BioNTech), have gone from nonexistent to about 95% effectiveness in 10 months. Public-health officials and governments now have the dual challenge of convincing the public that the vaccines are both safe and scientifically sound, as well as figuring out how to distribute billions of doses. Here’s what we know so far about how that’s going. When can I get vaccinated? That depends. Manufacturers have already begun producing vaccines, betting that they will be effective, so they can be ready to ...
Source: TIME: Science - November 19, 2020 Category: Science Authors: Alice Park Tags: Uncategorized COVID-19 Source Type: news

The Great Vaccine Race: Inside the Unprecedented Scramble to Immunize the World Against COVID-19
The cleverest of enemies thrive on surprise attacks. Viruses—and coronaviruses in particular—know this well. Remaining hidden in animal hosts for decades, they mutate steadily, sometimes serendipitously morphing into more effective and efficient infectious agents. When a strain with just the right combination of genetic codes that spell trouble for people makes the leap from animal to human, the ambush begins. Such was the case with SARS-CoV-2, the coronavirus behind COVID-19, and the attack was mostly silent and insidious at first. Many people infected with SARS-CoV-2 remained oblivious as they served as the v...
Source: TIME: Health - September 10, 2020 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 Magazine Source Type: news

AstraZeneca Paused Its COVID-19 Vaccine Trial to Perform a Safety Review. That ’s Not Bad News
AstraZeneca, the U.K.-based pharmaceutical company behind one of the world’s most promising COVID-19 vaccine candidates, has paused its trials due to “a single event of an unexplained illness that occurred in the UK Phase III trial,” the company announced Sept. 9. The news is disappointing, but it shows the development process is happening as it should. It is not uncommon for drug or vaccine trials to hit snags, even at advanced stages. Indeed, part of the reason vaccines go through multiple phases of testing, with increasingly large numbers of patients, is to catch rare but potentially serious side effec...
Source: TIME: Health - September 9, 2020 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized COVID-19 Source Type: news

AstraZeneca Resumed Its COVID-19 Vaccine Trial After Pausing for Safety Review
This story has been updated to reflect AstraZeneca’s vaccine trial resuming. AstraZeneca, the U.K.-based pharmaceutical company behind one of the world’s most promising COVID-19 vaccine candidates, has resumed its U.K. trial after pausing it due to “a single event of an unexplained illness,” the company announced Sept. 12. While AstraZeneca did not initially specify the nature of the study participant’s “unexplained illness,” an anonymous source told the New York Times that a trial participant in the U.K. was recently diagnosed with an inflammatory condition that affects the spinal...
Source: TIME: Health - September 9, 2020 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized COVID-19 Source Type: news

Johnson & Johnson Receives Positive CHMP Opinion for Janssen ’s Investigational Preventive Ebola Vaccine Regimen
Discussions with the FDA are ongoing to define the required data set for filing Janssen’s Ebola vaccine regimen under the FDA’s Animal Rule licensure pathway. About Janssen’s Ebola Vaccine Regimen The Janssen investigational preventive Ebola vaccine regimen (Ad26.ZEBOV, MVA-BN-Filo) utilizes a viral vector strategy in which viruses – in this case adenovirus serotype 26 (Ad26) and Modified Vaccinia Virus Ankara (MVA) – are genetically modified so that they cannot replicate in human cells. In addition, these vectors are modified to safely carry the genetic code of an Ebola virus protein in order to trigger an immun...
Source: Johnson and Johnson - May 29, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

All Your Coronavirus Questions, Answered
One of the worst symptoms of any plague is uncertainty—who it will strike, when it will end, why it began. Merely understanding a pandemic does not stop it, but an informed public can help curb its impact and slow its spread. It can also provide a certain ease of mind in a decidedly uneasy time. Here are some of the most frequently asked questions about the COVID-19 pandemic from TIME’s readers, along with the best and most current answers science can provide. A note about our sourcing: While there are many, many studies underway investigating COVID-19 and SARS-CoV-19, the novel coronavirus that causes the illn...
Source: TIME: Health - April 14, 2020 Category: Consumer Health News Authors: TIME Staff Tags: Uncategorized COVID-19 Explainer Source Type: news