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Metabolic Control of Dendritic Cell Functions: Digesting Information
In conclusion, a delicate balance of the complex system of nutrient sensing and mTOR (mTORC1) signaling is crucial to ensure appropriate development of DCs (23). Strikingly, loss of both mTOR complexes results in opposite effects on in vivo DC development compared with loss of mTORC1 alone, probably indicating differential inhibition of mTOR downstream targets and collaboration of mTOR complexes. Indeed, DC loss upon TSC1 deficiency is accompanied by increased DC apoptosis and enhanced metabolic activity due to TSC1-dependent inhibition of Myc, an effector downstream of mTOR (Figure 1), and reversed upon Myc loss (35). Of ...
Source: Frontiers in Immunology - April 24, 2019 Category: Allergy & Immunology Source Type: research

Fever and confusion in a returning soldier
A 36–year–old army engineer returned from a 6–week deployment in Afghanistan. He had complained of upper respiratory tract infection even before his travel. On return he was found to be increasingly sleepy and later developed unsteadiness, slurred speech and confusion. His initial blood tests were normal, with CSF and MRI suggesting signs of encephalitis. He continued to deteriorate, requiring intubation and ventilation. Several bacterial, viral, protozoal and fungal tests were negative. He developed pancytopenia requiring frequent packed red cell and platelet transfusions. Spleen was found to be marginal...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Chandratheva, A., Singh, A. R., Sturman, S., Chaganti, S., Jacob, S. Tags: Immunology (including allergy), HIV/AIDS, Tropical medicine (infectious diseases), Drugs: CNS (not psychiatric), Epilepsy and seizures, Infection (neurology), Memory disorders (psychiatry) Association of British Neurologists (ABN) joint meeting with the Source Type: research