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Drug: Metformin
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Sex differences in oxidative stress level and antioxidative enzymes expression and activity in obese pre-diabetic elderly rats treated with metformin or liraglutide
CONCLUSIONS: Obesity and antidiabetic drugs caused sex-related differences in the level of antioxidative parameters. Liraglutide exhibited stronger antioxidative effects than metformin. These results indicate that weight gain due to HSHFD is crucial for developing oxidative stress and for inhibiting antioxidative protective mechanisms.PMID:34212558 | PMC:PMC8275945 | DOI:10.3325/cmj.2021.62.215
Source: Croatian Medical Journal - July 2, 2021 Category: General Medicine Authors: Anita Mati ć Rosemary Vukovi ć Marija Heffer Marta Balog Vedrana Ivi ć Robert Gaspar Eszter Ducza Kalman F Szucs Adrienn Seres Sandor G Vari Ines Drenjan čević Source Type: research
Metformin and lipopolysaccharide regulate transcription of < em > NFATc2 < /em > gene < em > via < /em > the transcription factor RUNX2
CONCLUSION: pGL3-NFATc2-promoter can be transcribed and activated in 293F cells, and LPS and metformin can activate the transcription of pGL3- NFATc2-promoter in a RUNX2-dependent manner.PMID:35426808 | PMC:PMC9010990 | DOI:10.12122/j.issn.1673-4254.2022.03.16
Source: Journal of Southern Medical University - April 15, 2022 Category: Universities & Medical Training Authors: X Xue Z Li M Zhao Source Type: research
