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Drug: Methotrexate
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IJERPH, Vol. 19, Pages 11464: Interstitial Pregnancy Treated with Mifepristone and Methotrexate with High Serum & beta;-hCG Level in a Patient Wishing to Preserve Fertility: Time to Define Standardized Criteria for Medical/Surgical Therapy?
We report the case of a 36-year-old primigravida who was 6 + 5 weeks pregnant, diagnosed with interstitial pregnancy by ultrasound, who had a very high serum β-hCG level (31,298 mIU/mL) and wanted to preserve her fertility. The patient was treated with one dose of mifepristone and a double dose of methotrexate since the decrease in the β-hCG serum level was less than 15% after the first dose. At the beginning, medical therapy was effective, as no embryonal cardiac activity was detected and serum β-hCG levels decreased early, but on the 20th day of hospitalization, the patient underwen...
Source: International Journal of Environmental Research and Public Health - September 12, 2022 Category: Environmental Health Authors: Felice Sorrentino Lorenzo Vasciaveo Vincenzo De Feo Erika Zanzarelli Elvira Grandone Guglielmo Stabile Luigi Nappi Tags: Case Report Source Type: research
Primary Central Nervous System Lymphoma: Clinical Characteristics, Treatment Options and Therapeutic Outcome in 36 Patients. A Single Center Experience
CONCLUSIONS: A difference in CR and PFS favored a more aggressive protocol, but the toxicity of the multiagent combinations was significantly higher. The prognosis in younger was better than in older patients, with higher rates of CR, PFS, and OS, although not statistically significant. Overall treatment outcomes are encouraging; however, there is a real need for an adaptive approach for older patients and balancing among the effectiveness and side effects.PMID:36309861
Source: The Israel Medical Association Journal - October 30, 2022 Category: General Medicine Authors: Miri Zektser Anat Rabinovich Uri Grinbaum Tzvi Porges Aya Gozlan Anna Gourevitch Kayed Al-Athamen Orit Barrett Ido Peles Tehila Kaisman-Elbaz Etai Levi Source Type: research
