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Metformin inhibits proliferation and promotes apoptosis of HER-2 positive breast cancer cells possibly through the Hippo-YAP pathway
CONCLUSION: Metformin can inhibit proliferation and promote apoptosis and epithelal-mesenchymal transition of HER-2 positive breast cancer cells possibly by that inhibing YAP and TAZ expression and their nuclear localization.PMID:35673919 | PMC:PMC9178637 | DOI:10.12122/j.issn.1673-4254.2022.05.16
Source: Journal of Southern Medical University - June 8, 2022 Category: Universities & Medical Training Authors: Y Xu T Xu Y Xiong J Huang Source Type: research

Dihydromyricetin improves cardiac insufficiency by inhibiting HMGB1 in diabetic rats
CONCLUSION: DHM treatment can improve cardiac function in diabetic rats possibly by down-regulation of HMGB1 and phospho-NF-κB p65 expressions in the myocardium.PMID:35673906 | PMC:PMC9178629 | DOI:10.12122/j.issn.1673-4254.2022.05.03
Source: Journal of Southern Medical University - June 8, 2022 Category: Universities & Medical Training Authors: S Liu Q Liu Q Peng Y Zhang J Wang Source Type: research

Effect of Dapagliflozin in Combination with Lobeglitazone and Metformin in Korean Patients with Type 2 Diabetes in Real-World Clinical Practice
CONCLUSION: Dapagliflozin, as an add-on or a switch therapy to lobeglitazone plus MFM, can be a suitable alternative for Korean patients with inadequately controlled T2DM. The combination therapy resulted in significant reductions in HbA1c levels, body weight, and blood pressure.PMID:36031782 | PMC:PMC9424781 | DOI:10.3349/ymj.2022.63.9.825
Source: Yonsei Medical Journal - August 29, 2022 Category: Universities & Medical Training Authors: Da Hea Seo Young Ju Suh Yongin Cho Seong Hee Ahn Seongha Seo Seongbin Hong Yong-Ho Lee Young Ju Choi Eunjig Lee So Hun Kim Source Type: research