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Metformin and lipopolysaccharide regulate transcription of < em > NFATc2 < /em > gene < em > via < /em > the transcription factor RUNX2
CONCLUSION: pGL3-NFATc2-promoter can be transcribed and activated in 293F cells, and LPS and metformin can activate the transcription of pGL3- NFATc2-promoter in a RUNX2-dependent manner.PMID:35426808 | PMC:PMC9010990 | DOI:10.12122/j.issn.1673-4254.2022.03.16
Source: Journal of Southern Medical University - April 15, 2022 Category: Universities & Medical Training Authors: X Xue Z Li M Zhao Source Type: research
Sodium Glucose Cotransporter-2 Inhibitors as an Add-on Therapy to Metformin Plus Dipeptidyl Peptidase-4 Inhibitor in Patients with Type 2 Diabetes
CONCLUSION: Adding SGLT-2 inhibitors is not inferior to adding SU as a third-line ADD to metformin plus DPP-4 inhibitor combination therapy.PMID:35619577 | PMC:PMC9171674 | DOI:10.3349/ymj.2022.63.6.539
Source: Yonsei Medical Journal - May 27, 2022 Category: Universities & Medical Training Authors: Jaehyun Bae Young-Eun Kim Minyoung Lee Yong-Ho Lee Byung-Wan Lee Bong-Soo Cha Eun Seok Kang Source Type: research
Fucoxanthin regulates Nrf2/Keap1 signaling to alleviate myocardial hypertrophy in diabetic rats
CONCLUSION: Fucoxanthin possesses strong inhibitory activities against diabetic cardiomyocyte hypertrophy and myocardial fibrosis and is capable of up-regulating Nrf2 signaling to promote the expression of its downstream antioxidant proteins SOD1 and HO-1 to reduce the level of ROS.PMID:35673921 | PMC:PMC9178635 | DOI:10.12122/j.issn.1673-4254.2022.05.18
Source: Journal of Southern Medical University - June 8, 2022 Category: Universities & Medical Training Authors: D Zheng L Chen Q Wei Z Zhu Z Liu L Jin G Yang X Xie Source Type: research
Metformin inhibits proliferation and promotes apoptosis of HER-2 positive breast cancer cells possibly through the Hippo-YAP pathway
CONCLUSION: Metformin can inhibit proliferation and promote apoptosis and epithelal-mesenchymal transition of HER-2 positive breast cancer cells possibly by that inhibing YAP and TAZ expression and their nuclear localization.PMID:35673919 | PMC:PMC9178637 | DOI:10.12122/j.issn.1673-4254.2022.05.16
Source: Journal of Southern Medical University - June 8, 2022 Category: Universities & Medical Training Authors: Y Xu T Xu Y Xiong J Huang Source Type: research
Dihydromyricetin improves cardiac insufficiency by inhibiting HMGB1 in diabetic rats
CONCLUSION: DHM treatment can improve cardiac function in diabetic rats possibly by down-regulation of HMGB1 and phospho-NF-κB p65 expressions in the myocardium.PMID:35673906 | PMC:PMC9178629 | DOI:10.12122/j.issn.1673-4254.2022.05.03
Source: Journal of Southern Medical University - June 8, 2022 Category: Universities & Medical Training Authors: S Liu Q Liu Q Peng Y Zhang J Wang Source Type: research
Sodium Glucose Cotransporter-2 Inhibitors as an Add-on Therapy to Metformin Plus Dipeptidyl Peptidase-4 Inhibitor in Patients with Type 2 Diabetes
CONCLUSION: Adding SGLT-2 inhibitors is not inferior to adding SU as a third-line ADD to metformin plus DPP-4 inhibitor combination therapy.PMID:35619577 | PMC:PMC9171674 | DOI:10.3349/ymj.2022.63.6.539
Source: Yonsei Medical Journal - May 27, 2022 Category: Universities & Medical Training Authors: Jaehyun Bae Young-Eun Kim Minyoung Lee Yong-Ho Lee Byung-Wan Lee Bong-Soo Cha Eun Seok Kang Source Type: research
Fucoxanthin regulates Nrf2/Keap1 signaling to alleviate myocardial hypertrophy in diabetic rats
CONCLUSION: Fucoxanthin possesses strong inhibitory activities against diabetic cardiomyocyte hypertrophy and myocardial fibrosis and is capable of up-regulating Nrf2 signaling to promote the expression of its downstream antioxidant proteins SOD1 and HO-1 to reduce the level of ROS.PMID:35673921 | PMC:PMC9178635 | DOI:10.12122/j.issn.1673-4254.2022.05.18
Source: Journal of Southern Medical University - June 8, 2022 Category: Universities & Medical Training Authors: D Zheng L Chen Q Wei Z Zhu Z Liu L Jin G Yang X Xie Source Type: research
Metformin inhibits proliferation and promotes apoptosis of HER-2 positive breast cancer cells possibly through the Hippo-YAP pathway
CONCLUSION: Metformin can inhibit proliferation and promote apoptosis and epithelal-mesenchymal transition of HER-2 positive breast cancer cells possibly by that inhibing YAP and TAZ expression and their nuclear localization.PMID:35673919 | PMC:PMC9178637 | DOI:10.12122/j.issn.1673-4254.2022.05.16
Source: Journal of Southern Medical University - June 8, 2022 Category: Universities & Medical Training Authors: Y Xu T Xu Y Xiong J Huang Source Type: research
Dihydromyricetin improves cardiac insufficiency by inhibiting HMGB1 in diabetic rats
CONCLUSION: DHM treatment can improve cardiac function in diabetic rats possibly by down-regulation of HMGB1 and phospho-NF-κB p65 expressions in the myocardium.PMID:35673906 | PMC:PMC9178629 | DOI:10.12122/j.issn.1673-4254.2022.05.03
Source: Journal of Southern Medical University - June 8, 2022 Category: Universities & Medical Training Authors: S Liu Q Liu Q Peng Y Zhang J Wang Source Type: research
Sodium Glucose Cotransporter-2 Inhibitors as an Add-on Therapy to Metformin Plus Dipeptidyl Peptidase-4 Inhibitor in Patients with Type 2 Diabetes
CONCLUSION: Adding SGLT-2 inhibitors is not inferior to adding SU as a third-line ADD to metformin plus DPP-4 inhibitor combination therapy.PMID:35619577 | PMC:PMC9171674 | DOI:10.3349/ymj.2022.63.6.539
Source: Yonsei Medical Journal - May 27, 2022 Category: Universities & Medical Training Authors: Jaehyun Bae Young-Eun Kim Minyoung Lee Yong-Ho Lee Byung-Wan Lee Bong-Soo Cha Eun Seok Kang Source Type: research
Fucoxanthin regulates Nrf2/Keap1 signaling to alleviate myocardial hypertrophy in diabetic rats
CONCLUSION: Fucoxanthin possesses strong inhibitory activities against diabetic cardiomyocyte hypertrophy and myocardial fibrosis and is capable of up-regulating Nrf2 signaling to promote the expression of its downstream antioxidant proteins SOD1 and HO-1 to reduce the level of ROS.PMID:35673921 | PMC:PMC9178635 | DOI:10.12122/j.issn.1673-4254.2022.05.18
Source: Journal of Southern Medical University - June 8, 2022 Category: Universities & Medical Training Authors: D Zheng L Chen Q Wei Z Zhu Z Liu L Jin G Yang X Xie Source Type: research
