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Specialty: Cardiology
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Total 1381 results found since Jan 2013.
ANGPTL3 Deficiency and Risk of Hepatic Steatosis
CONCLUSIONS: ANGPTL3 deficiency related to LoF mutations in ANGPTL3, as well as genetically determined reduction of plasma ANGPTL3 levels, is not associated with hepatic steatosis. Therapeutic approaches to inhibit ANGPTL3 production in hepatocytes are not necessarily expected to result in the increased risk for hepatic steatosis that was observed with vupanorsen.PMID:37712257 | DOI:10.1161/CIRCULATIONAHA.123.065866
Source: Circulation - September 15, 2023 Category: Cardiology Authors: Laura D'Erasmo Michele Di Martino Thomas Neufeld Tyler J Fraum Chul Joo Kang Kendall H Burks Alessia Di Costanzo Ilenia Minicocci Simone Bini Marianna Maranghi Giovanni Pigna Giancarlo Labbadia Jie Zheng Davide Fierro Anna Montali Fabrizio Ceci Carlo Cata Source Type: research
Refinement of the diagnostic approach for the identification of children and adolescents affected by familial hypercholesterolemia: Evidence from the LIPIGEN study
CONCLUSIONS: In children, the typical FH features are clearly less informative than in adults. A more thorough data collection, adding information about second-degree relatives, could improve the diagnosis of FH at younger age.PMID:37648636 | DOI:10.1016/j.atherosclerosis.2023.117231
Source: Atherosclerosis - August 30, 2023 Category: Cardiology Authors: Manuela Casula Marta Gazzotti Maria Elena Capra Elena Olmastroni Federica Galimberti Alberico L Catapano Cristina Pederiva LIPIGEN Group and the LIPIGEN Paediatric Group Source Type: research
Involvement of APOE in Incidence of Revascularization in Patients Affected by Peripheral Arterial Disease: A Prospective Study from Southern Italy
CONCLUSIONS: In our observational study, we confirm that the ε4 allele is associated with higher total peripheral revascularization in patients with advanced atherosclerotic vascular disease at prolonged follow-up.PMID:37629219 | PMC:PMC10455789 | DOI:10.3390/jcm12165178
Source: Atherosclerosis - August 26, 2023 Category: Cardiology Authors: Giuseppe Di Stolfo Michele Antonio Pacilli Davide Seripa Giovanni De Luca Maria Urbano Carlo Coli Carolina Gravina Antonio Greco Domenico Rosario Potenza Mauro Pellegrino Salvatori Gerit-Holger Schernthaner Pavel Poredos Mariella Catalano Sandra Mastroian Source Type: research
Metabolites Potentially Derived from Gut Microbiota Associated with Podocyte, Proximal Tubule, and Renal and Cerebrovascular Endothelial Damage in Early Diabetic Kidney Disease in T2DM Patients
In conclusion, in serum, arginine (sArg), butenoylcarnitine (sBCA), and indoxyl sulfate (sIS) expressed a biomarker potential in terms of renal endothelial dysfunction and carotid atherosclerosis, whereas sorbitol (sSorb) may be a potential biomarker of blood-brain barrier (BBB) dysfunction. In urine, BCA and IS were associated with markers of podocyte damage, whereas PCS correlated with markers of PT dysfunction.PMID:37623837 | DOI:10.3390/metabo13080893
Source: Atherosclerosis - August 25, 2023 Category: Cardiology Authors: Lavinia Balint Carmen Socaciu Andreea Iulia Socaciu Adrian Vlad Florica Gadalean Flaviu Bob Oana Milas Octavian Marius Cretu Anca Suteanu-Simulescu Mihaela Glavan Silvia Ienciu Maria Mogos Dragos Catalin Jianu Sorin Ursoniu Victor Dumitrascu Daliborca Vla Source Type: research
Consensus document on Lipoprotein(a) from the Italian Society for the Study of Atherosclerosis (SISA)
CONCLUSIONS: Awaiting the approval of selective Lp(a)-lowering drugs, an intensive management of the other risk factors for individuals with elevated Lp(a) levels is strongly recommended.PMID:37586921 | DOI:10.1016/j.numecd.2023.07.019
Source: Atherosclerosis - August 16, 2023 Category: Cardiology Authors: Giulia Chiesa Maria Grazia Zenti Andrea Baragetti Carlo M Barbagallo Claudio Borghi Furio Colivicchi Aldo P Maggioni Davide Noto Matteo Pirro Angela A Rivellese Tiziana Sampietro Francesco Sbrana Marcello Arca Maurizio Averna Alberico L Catapano Source Type: research
Clinical Approach in the Management of Paediatric Patients with Familial Hypercholesterolemia: A National Survey Conducted by the LIPIGEN Paediatric Group
Nutrients. 2023 Aug 5;15(15):3468. doi: 10.3390/nu15153468.ABSTRACTDetection and treatment of patients with familial hypercholesterolemia (FH) starting from childhood is fundamental to reduce morbidity and mortality. The activity of National realities such as the LIPIGEN (LIpid transPort disorders Italian GEnetic Network) Paediatric Group, founded in 2018, is a milestone in this context. The aim of this exploratory survey, conducted in October 2021 among Italian lipid clinics included in the LIPIGEN Paediatric Group, was to investigate the current clinical approach in the management and treatment of paediatric patients wit...
Source: Atherosclerosis - August 12, 2023 Category: Cardiology Authors: Cristina Pederiva Marta Gazzotti Marcello Arca Maurizio Averna Giuseppe Banderali Giacomo Biasucci Marta Brambilla Paola Sabrina Buonuomo Paolo Calabr ò Francesco Cipollone Nadia Citroni Sergio D'Addato Maria Del Ben Simonetta Genovesi Ornella Guardamagn Source Type: research
Early Vascular Ageing in adolescents with migraine with aura: a community-based study
CONCLUSIONS: In line with previous large-scale studies in adults, we could not demonstrate relevant associations of migraine with aura with markers of arterial stiffness or subclinical atherosclerosis making early vascular ageing an unlikely pathophysiological link between migraine with aura and cardiovascular diseases.TRIAL REGISTRATION: First registered on ClinicalTrials.gov 29/04/2019 (NCT03929692).PMID:37528337 | DOI:10.1186/s12872-023-03409-2
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: Beno ît Bernar Nina Gande Anna Katharina Stock Anna Staudt Raimund Pechlaner Christoph Hochmayr Katharina Kaltseis Bernhard Winder Sophia Julia J Kiechl Gregor Broessner Ralf Geiger Stefan Kiechl Early Vascular Ageing (EVA) Tyrol Study Group Ursula Kiech Source Type: research
ANMCO Position paper: Colchicine as a therapeutic agent in coronary syndromes
G Ital Cardiol (Rome). 2023 Aug;23(8):665-674. doi: 10.1714/4068.40536.ABSTRACTWith the growing knowledge about the role of inflammatory processes in the pathogenesis of atherosclerotic lesions, inflammation has been identified as a cardiovascular risk factor and therapeutic target to reduce the residual risk in patients with atherosclerotic disease. Several therapeutic agents with anti-inflammatory action have been tested to evaluate their efficacy and safety in the context of atherosclerotic cardiovascular diseases. Among these, colchicine, a drug with multiple therapeutic effects including anti-inflammatory action, in r...
Source: Atherosclerosis - July 26, 2023 Category: Cardiology Authors: Stefania Angela Di Fusco Massimo Imazio Vittoria Rizzello Laura Gatto Antonella Spinelli Stefano Aquilani Carmine Riccio Pasquale Caldarola Federico Nardi Leonardo De Luca Michele Massimo Gulizia Domenico Gabrielli Fabrizio Oliva Furio Colivicchi Source Type: research
Cardiovascular prevention in childhood: a consensus document of the Italian Society of Cardiology Working Group on Congenital Heart Disease and Cardiovascular Prevention in Paediatric Age
J Cardiovasc Med (Hagerstown). 2023 Aug 1;24(8):492-505. doi: 10.2459/JCM.0000000000001488. Epub 2023 Jun 26.ABSTRACTCardiovascular diseases (CVD) may be manifested from a very early age. Genetic and environmental (epigenetic) factors interact to affect development and give rise to an abnormal phenotypical expression of genetic information, although not eliciting changes in the nucleotide sequence of DNA. It has been scientifically proven that increased oxidative stress (OS) caused by disease (overweight, obesity, diabetes), nutritional imbalances, unhealthy lifestyles (smoking, alcohol, substance abuse) in the mother duri...
Source: Atherosclerosis - July 6, 2023 Category: Cardiology Authors: Francesco Martino Pier Paolo Bassareo Eliana Martino Francesco Romeo Giuseppe Calcaterra Pasquale Perrone Filardi Ciro Indolfi Savina Nodari Vincenzo Montemurro Paolo Guccione Giovanni Di Salvo Massimo Chessa Roberto Pedrinelli Giuseppe Mercuro Francesco Source Type: research
