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Total 8999 results found since Jan 2013.

Pure red cell aplasia as a presenting feature in systemic lupus erythematosus and association with thymoma, hypothyroidism and hypoparathyroidism: a case report and literature review.
Abstract This paper presents a 54-year-old female with lupus whom severe anaemia due to pure red cell aplasia (PRCA) was the first manifestation. There was seven years interval between PRCA onset and diagnosis of lupus. Thymectomy due to thymoma had been carried out six years before but anaemia sustained. Hypothyroidism and hypoparathyroidism were other associated diseases. Severe anaemia and the need for monthly blood infusions were resolved following treatment with Prednisolone, Hydroxychloroquine and Levothyroxine. PMID: 24338260 [PubMed - in process]
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Fallahi S, Akbarian M, Dabiri S Tags: Iran J Allergy Asthma Immunol Source Type: research

The role of interleukin-23 in stability of in vitro T helper-17 cells.
Abstract Interleukin (IL)-17-producing T helper (Th)-17 cells have recently been explained as a distinct population of CD4+ T cells which play an important role in immunity against infectious agents. Establishment of persistent phenotype of Th17 cells and recognition of lineage-deviating factors are of most attractive goals in modern researches in immunology. Although IL-6 and TGF-β are frequently used to differentiate naive T cells to Th17 phenotype in mouse models, the application of IL-23 and its importance in preventing cells from plasticity needs to be more investigated. Our main objective was to evaluate th...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Taherian M, Razavi AR, Izad M, Boghozian R, Namdari H, Ghayedi M, Rahimzadeh P, Bidad K, Salehi E Tags: Iran J Allergy Asthma Immunol Source Type: research

Proinflammatory cytokines in the embolic model of cerebral ischemia in rat.
Abstract Increased levels of proinflammatory cytokines have been recorded after the onset of transient or permanent brain ischemia and are usually associated with exacerbation of ischemic injury. Embolic stroke model is more relevant to the pathophysiological situation in such patients, because the majority of ischemic injuries in humans are induced by old thrombi that originate from the heart and carotid arteries. Therefore, the aim of the present study was to investigate changes of inflammatory cytokines after embolic stroke. Rats were subjected to embolic stroke, induced by a natural old clot which was injected...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Jafarinaveh HR, Allahtavakoli M, Rezazadeh H, Kazemi Arababadi M, Taghavi MM, Shamsizadeh A, Rahmani MR Tags: Iran J Allergy Asthma Immunol Source Type: research

Mannan-binding lectin serum levels in 593 healthy Iranian children and adults.
Abstract Mannan-binding lectin (MBL) is a vital protein of innate immune system and has two critical functions: complement activation through the lectin pathway and opsonization. MBL deficiency has been classified as the most common inherited immunodeficiency known in humans (about 30% of the population), and is associated with predisposition to infections and high risk of some autoimmune diseases. The purpose of this study was to determine the profile of MBL serum level in Iranian healthy population in association with sex and age groups for the first time. We studied the serum concentration of MBL in 593 Iranian...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Zahedifard S, Rashidi E, Shams S, Saghafi S, Fazlollahi M, Talebzadeh A, Kazemnejad A, Soltani A, Pourpak Z Tags: Iran J Allergy Asthma Immunol Source Type: research

Evaluation of immunological parameters in diabetic patients: are these patients immunodeficient?
Abstract It has been widely thought that diabetic patients are prone to infections due to hyperglycemia induced immunodeficiency; the present study was designed to examine this opinion. In diabetic patients and normal control groups T-cell reactivity to hsp-60 molecule, tetanus toxoid recall antigen (TT) and phytohemagglutinin-A (PHA) mitogen were evaluated The number of circulating IFN-γ, IL-10 and IL-13 cytokine producing cells stimulated with above antigens or mitogen as well as the serum levels of Th1/Th2 type cytokines were determined. Total serum immunoglobulins (IgG, IgA, IgM), C3, C4 and CH50 were also me...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Moazezi Z, Hosseinian A, Ahmad Moazam E, Eslami MB, Mosavi E, Akhavan-Niaki H, Bijani A, Schloot N, Mostafazadeh A Tags: Iran J Allergy Asthma Immunol Source Type: research

Gastroesophagial reflux disease and asthma in pregnant women with dyspnea.
In conclusion, the prevalence of GERD was quite high in pregnant women, irrespective of the fact that they were asthmatic or non-asthmatic. Further studies evaluating women throughout pregnancy will inform us more about this relationship. PMID: 24338255 [PubMed - in process]
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Bidad K, Heidarnazhad H, Pourpak Z, Shayestefar G, Moayeri H, Zendehdel N Tags: Iran J Allergy Asthma Immunol Source Type: research

Vitamin e supplementation, lung functions and clinical manifestations in children with moderate asthma: a randomized double blind placebo- controlled trial.
Abstract Asthma is the most common chronic inflammatory disorder characterized by cough, wheezing and dyspnea in children. Nutrition is an important factor which influences on induction and exacerbation of asthma. There are controversies to use Vitamin E in asthmatic patients. The aim of this study was to evaluate the effect of vitamin E supplement in children with moderate asthma. This is a randomized double blind placebo-controlled trial performed on children (age 2-17 years old) with moderate asthma (5-17 years old) from March 2010 to March 2012. Case group were treated with fluticasone and vitamin E (50mg/day)...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Ghaffari J, Farid Hossiani R, Khalilian A, Nahanmoghadam N, Salehifar E, Rafatpanah H Tags: Iran J Allergy Asthma Immunol Source Type: research

Alteration in Frequency and Function of CD4+CD25+FOXP3+ Regulatory T cells in Patients with Immune Thrombocytopenic Purpura.
Abstract Immune thrombocytopenic purpura (ITP) is an autoimmune bleeding disorder characterized by production of auto-antibodies against platelet antigens. It is obvious that regulatory T cells (Tregs) have a major role in controlling immune homeostasis and preventing autoimmunity.To investigate the frequency and functions of Tregs, twenty ITP patients and twenty age- and sex-matched healthy controls were recruited. The peripheral blood mononuclear cells were isolated and the proportion of Tregs was defined by flow cytometry method. The expression of immune-regulatory markers, cytotoxic T-lymphocyte associated ant...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Arandi N, Mirshafiey A, Jeddi-Tehrani M, Shaghaghi M, Sadeghi B, Abolhassani H, Sharifian RA, Rahiminejad MS, Aghamohammadi A Tags: Iran J Allergy Asthma Immunol Source Type: research

Abortion in Iranian legal system: a review.
Abstract Abortion traditionally means, "to miscarry" and is still known as a problem which societies has been trying to reduce its rate by using legal means. Despite the pregnant women and fetuses have being historically supported; abortion was firstly criminalized in 1926 in Iran, 20 years after establishment of modern legal system. During next 53 years this situation changed dramatically, so in 1979, the time of Islamic Revolution, aborting fetuses before 12 weeks and therapeutic abortion (TA) during all the pregnancy length was legitimate, based on regulations that used medical justification. After 1979 the sit...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Abbasi M, Shamsi Gooshki E, Allahbedashti N Tags: Iran J Allergy Asthma Immunol Source Type: research

Disseminated aspergillosis as the herald manifestation of chronic granulomatous disease in an adult patient.
We report a disseminated aspergillosis as the representative of adult onset chronic granulomatous disease without previous infection, with dramatic response to combination of antifungal and interferon therapy.  PMID: 24338231 [PubMed - in process]
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Alavi Darazam I, Akhavan Zanjani H, Sanaee D, Tabarsi P, Alavi Moghaddam M, Mansouri D Tags: Iran J Allergy Asthma Immunol Source Type: research

Assessment of the quality of life in patients with bronchial asthma, before and after yoga: a randomised trial.
The objective of this study was to assess the effect of yoga on quality of life in patients with bronchial asthma.120 non-smoking male and female patients of asthma in the age group of 17-50 years were randomized into two groups i.e. Group A (Yoga group) and Group B (control group). All patients remained on their prescribed medication, but Group A patients practiced yoga breathing exercises for 8 weeks.Asthma Quality of Life Questionnaire (AQLQ) and diary record was used to assess quality of life, number and severity of asthmatic attacks, and the dosage of the medication required at baseline and after 8 weeks.Group A subje...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Sodhi C, Singh S, Bery A Tags: Iran J Allergy Asthma Immunol Source Type: research

The effect of personality disorders on asthma severity and quality of life.
Abstract Assesment of health related quality of life (HRQL) is increasingly recognized as an important part of the patient care in asthma. We aimed to evaluate the effect of personality disorders (PDs) on HRQL and the severity of disease in asthmatic patients.Ninety seven consecutive patients with asthma and ninety healthy controls were included. All patients completed a Short Form-36 health survey (SF-36) and Structured Clinical Interview Form for DSM-III-R Axis-II Disorders (SCID-II).All SF-36 questionnaire scores of asthmatic patients were significantly lower than the controls. There were statistical difference...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Yılmaz A, Cumurcu BE, Etikan I, Hasbek E, Doruk S Tags: Iran J Allergy Asthma Immunol Source Type: research

Chronic aspiration of gastric and duodenal contents and their effects on inflammatory cytokine production in respiratory system of rats.
Abstract Gastroesophageal reflux disease (GERD) is defined with clinical symptoms of heart burning and regurgitation. It may be associated with external esophageal symptoms such as chronic cough, asthma, laryngitis, chronic lung disease, sinusitis and pulmonary fibrosis. In the present study, rats with chronic aspiration of gastroduodenal contentswere studied for cellular phenotypes and cytokine concentrations in bronchoalveolar lavage and lung tissue.Thirty-six male Albino N-MRI rats were randomly divided into six groups. After anesthesia and tracheal intubation, the animals received either 0.5ml/kg of normal sal...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Samareh Fekri M, Poursalehi HR, Najafipour H, Shahouzahi B, Bazargan Harandi N Tags: Iran J Allergy Asthma Immunol Source Type: research

Significant Changes of 5-Hydroxytriptamine 3A Receptor Gene Expression in Peripheral Blood Mononuclear Cells of Allergic Asthmatic Patients.
Abstract Asthma is a chronic inflammatory disorder of the airways. The stress is a factor for asthma which indicates a disorder in the function of communicational mediators of nervous and immunological systems such as neurotransmitters. A study indicated that blood serotonin concentration increases in asthmatic patients. Other study indicates that one kind of the serotonin receptors, named 5HT3A, on PBMCs causes secretion of series of pro-inflammatory cytokines which play important roles in allergic asthma disease. Thus, we evaluated the ratio expression level of 5HT3A subtype receptors in asthma.The Peripheral Bl...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Mohammadi Amirabad L, Ahangari G, Derakhshan Deilami G Tags: Iran J Allergy Asthma Immunol Source Type: research

Lack of Association between Single Nucleotide Polymorphism rs10818488 in TRAF1/C5 Region and Rheumatoid Arthritis in Iranian Population.
Abstract The association of rs10818488 SNP located in TRAF1/C5 region with Rheumatoid Arthritis (RA), has been picked up by genome-wide association studies. Independent studies in different populations revealed inconsistent results. The aim of this study was to investigate the possible association of this SNP with RA in Iranian population.A total of 362 cases and 422 healthy controls were recruited in this study. Genomic DNA was extracted from whole blood and the genotyping was performed by PCR-RFLP (Polymerase Chain Reaction-Restriction Fragment Length Polymorphism). A set of genotypes was confirmed by sequencing...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2013 Category: Allergy & Immunology Authors: Ahmadlou S, Akhiani M, Salimzadeh A, Keramatipour M Tags: Iran J Allergy Asthma Immunol Source Type: research