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Generation of CHOPi012-A iPSC line from a patient with visceral myopathy-related chronic intestinal pseudo-obstruction
Stem Cell Res. 2023 Aug 1;71:103176. doi: 10.1016/j.scr.2023.103176. Online ahead of print.ABSTRACTVisceral myopathies are debilitating conditions characterized by dysfunction of smooth muscle in visceral organs (bowel, bladder, and uterus). Individuals affected by visceral myopathy experience feeding difficulties, growth failure, life-threatening abdominal distension, and may depend on intravenous nutrition for survival. Unfortunately, our limited understanding of the pathophysiology of visceral myopathies means that current therapies remain supportive, with no mechanism-based treatments. We developed a patient-derived iP...
Source: Cell Research - August 12, 2023 Category: Cytology Authors: Sohaib K Hashmi Sabine Schneider Alyssa L Gagne Jean Ann Maguire Paul Gadue Robert O Heuckeroth Deborah L French Source Type: research

Hypothyroidism as a Predictor of Surgical Outcomes in the Elderly
Conclusions It is recommended to post-pone elective surgery in elderly patients with hypothyroidism until an euthyroid state is achieved. If patients need urgent or emergent surgery, it is recommended to proceed with surgery only if they have mild or moderate hypothyroidism. Replacement therapy should be started preoperatively and there should be growing attention to the possible occurrence of minor post-operative complications in hypothyroid patients. As suggested by the American Thyroid Association (ATA), the treatment in elderly patients should be initiated at low doses with slow titration based on serum TSH evaluation...
Source: Frontiers in Endocrinology - April 23, 2019 Category: Endocrinology Source Type: research