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Docosahexaenoic Acid Increases the Potency of Soluble Epoxide Hydrolase Inhibitor in Alleviating Streptozotocin-Induced Alzheimer ’s Disease-Like Complications of Diabetes
Conclusion In the present study, we demonstrated that sEHI alleviates cognitive and memory impairment associated with diabetes-induced Alzheimer-like complication. The positive effect of sEHI TPPU on memory was associated with a reduction in oxidative stress and inflammation in the brain with a parallel decrease in the mRNA level of APP and activity of AChE. The DHA potentiated the effect of TPPU. Edaravone at a higher dose also alleviated memory impairment via decreasing oxidative stress and inflammation. Author Contributions RP, MA, SA, ML, and SG planned the experiments. RP, NB, KG, MA, and SA performed the experimen...
Source: Frontiers in Pharmacology - April 23, 2019 Category: Drugs & Pharmacology Source Type: research

Tracking Trachoma: How The Gambia Is Eliminating an Ancient Disease
PDF Version (4.5 MB) About This Article About This Article Supplemental Material Published: 11 December 2017 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Published: 11 December 2017 Note to reade...
Source: EHP Research - December 12, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Focus Source Type: research