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siRNA rescues nonhuman primates from advanced Marburg and Ravn virus disease
Ebolaviruses and marburgviruses belong to the family Filoviridae and cause high lethality in infected patients. There are currently no licensed filovirus vaccines or antiviral therapies. The development of broad-spectrum therapies against members of the Marburgvirus genus, including Marburg virus (MARV) and Ravn virus (RAVV), is difficult because of substantial sequence variability. RNAi therapeutics offer a potential solution, as identification of conserved target nucleotide sequences may confer activity across marburgvirus variants. Here, we assessed the therapeutic efficacy of lipid nanoparticle (LNP) delivery of a sing...
Source: Journal of Clinical Investigation - November 7, 2017 Category: Biomedical Science Authors: Emily P. Thi, Chad E. Mire, Amy C.H. Lee, Joan B. Geisbert, Raul Ursic-Bedoya, Krystle N. Agans, Marjorie Robbins, Daniel J. Deer, Robert W. Cross, Andrew S. Kondratowicz, Karla A. Fenton, Ian MacLachlan, Thomas W. Geisbert Source Type: research

MYC Is an Early Response Regulator of Human Adipogenesis in Adipose Stem Cells
by Chad Deisenroth, Michael B. Black, Salil Pendse, Linda Pluta, Sam M. Witherspoon, Patrick D. McMullen, Russell S. Thomas Adipose stem cell (ASC) differentiation is necessary for the proper maintenance and function of adipose tissue. The procurement and characterization of multipotent ASCs has enabled investigation into the molecular determinants driving human adipogenesis. Here, the transcription factor MYC was identified as a significant regulator of ASC differentiation. Expression of MYC transcript and protein was found to accumulate during the initial course of differentiation. Loss-of-function analysis using siRNA ...
Source: PLoS One - December 1, 2014 Category: Biomedical Science Authors: Chad Deisenroth et al. Source Type: research