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Total 207 results found since Jan 2013.

Effect of oral versus parenteral vitamin D3 supplementation on nuclear factor- κB and platelet aggregation in type 2 diabetic patients
In conclusion, restoring normal levels of vitamin D is an important determinant to maintain normal platelet function and reduce inflammation. Nevertheless, further long-term studies are still needed.PMID:37721213 | DOI:10.1139/cjpp-2022-0359
Source: Canadian Journal of Physiology and Pharmacology - September 18, 2023 Category: Drugs & Pharmacology Authors: Esraa Habiba Samia Ali Yehia Ghanem Ola Sharaki Wafaa Hewedy Source Type: research

High salt-induced morphological and glycocalyx remodeling of human vascular smooth muscle cells is reversible but induces a high sodium salt-like sensitive memory
Can J Physiol Pharmacol. 2023 Jun 8. doi: 10.1139/cjpp-2023-0087. Online ahead of print.ABSTRACTOur recent work showed that chronic high sodium salt (CHSS) induced hypertrophy and decreased glycocalyx in human vascular smooth muscle cells (hVSMCs). However, whether this CHSS effect is reversible at both the morphological and calcium homeostasis levels is unknown. In the present study, we tested the hypothesis that the effect of CHSS is reversible only at the morphological and intracellular levels of ionic homeostasis but permanently remodel the sensitivity of hVSMCs to a short-term increase of Na+. We tested the effects of...
Source: Canadian Journal of Physiology and Pharmacology - June 8, 2023 Category: Drugs & Pharmacology Authors: Yanick Simon Danielle Jacques Ghassan Bkaily Source Type: research

Evaluation of the Olo Prenatal Nutrition Follow-up Care for Vulnerable Pregnant Women
Conclusion: Olo follow-up care helped reduce the proportion of women below the recommended intake for micronutrients, but revising the food offered and strategies to address food insecurity may be necessary.PMID:37220174 | DOI:10.3148/cjdpr-2023-006
Source: Canadian Journal of Dietetic Practice and Research - May 23, 2023 Category: Nutrition Authors: No émie Charpentier Alex Dumas Anne-Sophie Morisset B énédicte Fontaine-Bisson Source Type: research

Population-Based Screening Using Low-Dose Chest Computed Tomography: A Systematic Review of Health Economic Evaluations
DiscussionAlmost all health economic evaluations of LDCT screening focused on lung cancer. Literature regarding the health economic benefits of simultaneous LDCT screening for multiple diseases is absent. Most studies suggest LDCT screening is cost-effective for current and former smokers aged 55 –74 with a minimum of 30 pack-years of smoking history. Consequently, more evidence on LDCT is needed to support further cost-effectiveness analyses. Preferably evidence on simultaneous screening for multiple diseases is needed, but alternatively, on single-disease screening.Registration of systematic reviewProspective Register ...
Source: PharmacoEconomics - March 22, 2023 Category: Health Management Source Type: research

Anti-inflammatory, antinociceptive, and vasorelaxant effects of a new pyrazole compound 5-(1-(2-fluorophenyl)-1 < em > H < /em > -pyrazol-4-yl)-1 < em > H < /em > -tetrazole: role of NO/cGMP pathway and calcium channels
Can J Physiol Pharmacol. 2023 Mar 3. doi: 10.1139/cjpp-2022-0428. Online ahead of print.ABSTRACTMolecular modification of compounds remains important strategy towards the discovery of new drugs. In this sense, this study presents a new pyrazole derivative 5-(1-(2-fluorophenyl)-1H-pyrazol-4-yl)-1H-tetrazole (LQFM039) and evaluated the anti-inflammatory, analgesic, and vasorelaxant effects of this compound as well the mechanisms of action involved in the pharmacological effects. For this, mice were orally treated with LQFM039 (17.5, 35, or 70 mg/kg) prior acetic acid-induced abdominal writhing, formalin, tail flick, and carr...
Source: Canadian Journal of Physiology and Pharmacology - March 3, 2023 Category: Drugs & Pharmacology Authors: Lanussy P de Oliveira Iziara F Florentino Daiany P B Silva Francine Pazini Fl ávio S de Carvalho Germ án Sanz Boniek G Vaz F ábio F da Rocha James O Fajemiroye Paulo C Ghedini Luciano M Li ão Ricardo Menegatti Elson A Costa Thiago S de Oliveira Source Type: research