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The Transcriptome of the Salivary Glands of Amblyomma aureolatum Reveals the Antimicrobial Peptide Microplusin as an Important Factor for the Tick Protection Against Rickettsia rickettsii Infection
Conclusion In conclusion, our data show that R. rickettsii exerts a modulatory effect on the transcriptional profile the SG of A. aureolatum. Moreover, RNAi experiments demonstrated that the knockdown of one microplusin increases the susceptibility of ticks to infection, suggesting that this is one important factor for the control of R. rickettsii. The functional characterization of the additional CDSs modulated by infection is warranted and might reveal other factors that interfere with the acquisition and/or transmission of this tick-borne pathogen. Ethics Statement All procedures involving vertebrate animals were car...
Source: Frontiers in Physiology - May 2, 2019 Category: Physiology Source Type: research

Characterization of α-Glucosidases From Lutzomyia longipalpis Reveals Independent Hydrolysis Systems for Plant or Blood Sugars
In this report, the authors consider that transglycosylation might be an adaptation for the obtention of monosaccharides from sucrose without the increase in osmolarity, as a simple hydrolytic reaction of a 0.7 M sucrose solution (phloem concentration) might result in osmotic shock for the midgut epithelial cells. In this respect, L. longipalpis enzymes might have the same biochemical adaptation. It would be very interesting to observe if this is a common trait of α-glucosidase from insects feeding on nectar or phloem sap, and verify if this is a case of evolutionary divergence or convergence. Two main mechanisms o...
Source: Frontiers in Physiology - April 9, 2019 Category: Physiology Source Type: research