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Total 51 results found since Jan 2013.
microRNA-130b downregulation potentiates chondrogenic differentiation of bone marrow mesenchymal stem cells by targeting SOX9
Braz J Med Biol Res. 2021 Feb 12;54(4):e10345. doi: 10.1590/1414-431X202010345. eCollection 2021.ABSTRACTOsteoarthritis (OA) is a chronic health condition. MicroRNAs (miRs) are critical in chondrocyte apoptosis in OA. We aimed to investigate the mechanism of miR-130b in OA progression. Bone marrow mesenchymal stem cells (BMSCs) and chondrocytes were first extracted. Chondrogenic differentiation of BMSCs was carried out and verified. Chondrocytes were stimulated with interleukin (IL)-1β to imitate OA condition in vitro. The effect of miR-130b on the viability, inflammation, apoptosis, and extracellular matrix of OA chondro...
Source: Brazilian Journal of Medical and Biological Research - February 24, 2021 Category: Research Authors: Penggui Zhang Guangming Gao Ziyu Zhou Xuejun He Source Type: research
GSE154531 siRNA sequencing of Aedes aegypti from two regions of the Americas reveals insect-specific virus profiles with geographic structure
Contributors : Ken Olson ; Nelson Lau ; Adeline Williams ; Qicheng MaSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Aedes aegyptiWe performed small RNA sequencing on recently colonized female Aedes aegypti from Mexico and Brazil. We compare small RNA profiles in midguts and abdomens (without ovaries) either non-bloodfed or 48 hours post non-infectious bloodmeal.
Source: GEO: Gene Expression Omnibus - July 1, 2021 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Aedes aegypti Source Type: research
Vutrisiran: First Approval
This article summarizes the milestones in the development of vutrisiran leading to this first approval in hATTR amyloi dosis.
Source: Drugs - August 23, 2022 Category: Drugs & Pharmacology Source Type: research
Stable expression of shRNA for the control of recombinant adenovirus replication
Braz J Med Biol Res. 2023 Jul 21;56:e12682. doi: 10.1590/1414-431X2023e12682. eCollection 2023.ABSTRACTPreventing the replication of adenovirus could have practical uses, such as controlling infection with wild-type virus or in applications involving recombinant vectors. Mainly transient methods have been used to inhibit adenovirus replication, including siRNA or drugs. Here, we tested whether stable expression of shRNA designed to target hexon, Iva2, or pol can inhibit the replication of a recombinant adenoviral vector, Ad-LacZ (serotype 5, E1/E3 deleted), in 293T cells. Significant knockdown correlating with reduced Ad-L...
Source: Brazilian Journal of Medical and Biological Research - July 26, 2023 Category: Research Authors: M V G Lana F Antunes N G Tessarollo B E Strauss Source Type: research
