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Source: Journal of Stroke and Cerebrovascular Diseases
Condition: Disability
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Total 286 results found since Jan 2013.
Early Prognostication of 1-Year Outcome After Subarachnoid Hemorrhage: The FRESH Score Validation
Background and Aim: The FRESH score is a tool to prognosticate long-term outcomes after spontaneous subarachnoid hemorrhage (SAH). Here, for the first time, we aimed to externally validate the disability part of FRESH using its original four score variables. Methods: A total of 107 patients with SAH were prospectively enrolled in the Yale Acute Brain Injury Biorepository between September 2014 and January 2018. 12-month functional outcome was recorded prospectively by trained study investigators using the modified Rankin Scale (mRS).
Source: Journal of Stroke and Cerebrovascular Diseases - July 17, 2019 Category: Neurology Authors: Jens Witsch, Lindsey Kuohn, Ryan Hebert, Branden Cord, Lauren Sansing, Emily J. Gilmore, David Y. Hwang, Nils Petersen, Guido J. Falcone, Charles Matouk, Kevin N. Sheth Source Type: research
Cerebrovascular Correlates of Dementia in Community-Dwelling Older Adults Living in Rural Communities – The Three Villages Study. Rationale and Protocol of a Population-Based Prospective Cohort Study
Background: Despite the assumption that dementia is increasing in rural areas of Latin America, there is no information on the burden and risk factors leading to dementia in these settings. Aims: To assess prevalence and incidence of dementia, and its cerebrovascular correlates in an established cohort of community-dwelling older adults living in rural Ecuador, and to explore the impact of dementia on functional disability and the role of the social determinants of health in the above-mentioned relationships.
Source: Journal of Stroke and Cerebrovascular Diseases - February 3, 2020 Category: Neurology Authors: Oscar H. Del Brutto, Robertino M. Mera, Victor J. Del Brutto, Aldo F. Costa, Bettsy Y. Recalde Source Type: research
The Effect of Dry Needling on Lower Limb Dysfunction in Poststroke Survivors
Background: Spasticity is one of the main complications in poststroke survivors leading to difficulties in walking and standing resulting in high levels of disability. Objective: The aim of the study was to investigate the effects of deep dry needling on lower limb dysfunction in poststroke spastic patients. Methods: A randomized clinical trial conducted in poststroke survivors who were assigned to one of 2 groups: Deep dry needling (intervention group) and sham dry needling (control group). The primary outcome measures were Modified Modified Ashworth Scale (MMAS) and functional tests (timed up and go test, 10-meter walk test).
Source: Journal of Stroke and Cerebrovascular Diseases - April 20, 2020 Category: Neurology Authors: Shima Ghannadi, Ardalan Shariat, Noureddin Nakhostin Ansari, Zahra Tavakol, Roshanak Honarpishe, Jan Dommerholt, Pardis Noormohammadpour, Lee Ingle Source Type: research
Serum substance P levels and early mortality of spontaneous intracerebral haemorrhage patients
Spontaneous intracerebral hemorrhage (ICH) is involved in many disabilities, death and resource consumption.1 Neuroinflammation could motivate a secondary brain injury in patients with ICH.2 –5
Source: Journal of Stroke and Cerebrovascular Diseases - May 13, 2020 Category: Neurology Authors: Leonardo Lorente, Mar ía M. Martín, Agustín F. González-Rivero, Antonia Pérez-Cejas, Rafael Sabatel, Luis Ramos-Gómez, Mónica Argueso, Juan J. Cáceres, Jordi Solé-Violán, Alejandro Jiménez, Victor García-Marín Source Type: research
Total small vessel disease score and functional outcomes following acute intracerebral hemorrhage
Cerebral microbleeds (CMBs), lacunar infarctions, periventricular hyperintensities (PVH), and deep white matter hyperintensities (DWMH) are markers of intrinsic brain damage. Recent studies have suggested that the total small vessel disease (SVD) score, which integrates all individual SVD markers, may better represent the total brain burden than a single marker.1 In patients after intracerebral hemorrhage (ICH), each SVD marker is an independent predictor for poor prognosis2 –4; however, few studies have examined the association between functional disabilities and the global SVD burden.
Source: Journal of Stroke and Cerebrovascular Diseases - July 15, 2020 Category: Neurology Authors: Yoko Kimura, Kaori Miwa, Junji Takasugi, Naoki Oyama, Kenichi Todo, Manabu Sakaguchi, Hideki Mochizuki, Tsutomu Sasaki Source Type: research
Dysphagia and disability in minor strokes – An institutional study
Ischemic strokes can be mild and non-disabling in around two third patients at onset.1 This is one of the major reason for delay in seeking medical attention, non-administration of thrombolytic therapy, incomplete evaluation and non-urgent initiation of secondary preventive strategies. Risk of early recurrence of neurological events is around 12%, with roughly half of them occurring in the first 48 h of onset.2 These strokes are not always associated with excellent outcome with short term disability ranging between 19% and 35% across various studies.
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Sapna Erat Sreedharan, Jaffar Vali Sayed, V P Vipina, Manju P Mohan, Rejith Paul, PN Sylaja Source Type: research
Sex-Specific Associations of Smoking with Spontaneous Subarachnoid Hemorrhage: Findings from Observational Studies
Subarachnoid hemorrhage (SAH) has long been considered a devastating disease because of its high mortality and disability rates.1,2 Despite the tremendous recent advances of medical and surgical treatments, SAH has remained a terrible disease. Hence, identification of modifiable risk factors for SAH is important to influence the incidence of SAH. In addition, some studies have reported that women are at higher risk for SAH compared with men;3,4 however, the specific reasons and the underlying risk factors for this sex difference remain unknown.
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Xiang Li, Tianyi Wang, Dongxia Feng, Zhongmou Xu, Xiang Xu, Heng Gao, Gang Chen Source Type: research
Electric Acupuncture Treatment Promotes Angiogenesis in Rats with Middle Cerebral Artery Occlusion Through EphB4/EphrinB2 Mediated Src/PI3K Signal Pathway
Cerebral infarction is one of the most common causes of disability and death worldwide. It is reported that electric acupuncture was able to improve the prognosis of cerebral infarction by promoting angiogenesis. However, the corresponding signal pathways of angiogenesis promotes by electric acupuncture treatment needs to be further explored.
Source: Journal of Stroke and Cerebrovascular Diseases - December 24, 2020 Category: Neurology Authors: Yuanhua Wu, Rong Hu, Xiuyan Zhong, Anbang Zhang, Bo Pang, Xiuqi Sun, Guangqi Zhu Source Type: research
Down-Regulation of miR-181a-5p Prevents Cerebral Ischemic Injury by Upregulating En2 and Activating Wnt/ β-catenin Pathway
Cerebral ischemic injury contributes to severe dysfunction of the brain, which triggers extremely high mortality and disability. The role of microRNA (miR)-181a-5p is documented in cerebral ischemic injury. Therefore, this study intended to further figure out the mechanism of miR-181a-5p in cerebral ischemic injury.
Source: Journal of Stroke and Cerebrovascular Diseases - December 22, 2020 Category: Neurology Authors: Xiaoming Song, Yongming Xue, Hairui Cai Source Type: research
Clinical Outcomes and Medical Costs of Hydration Therapy with Hydroxyethyl Starch (130/0.4) or Acute Single Infarction
Although a single infarction (SI) is typically predicted to have good outcomes, 20% –30% of SI patients experience secondary progressive motor deficits (PMD) occurring within a few days after SI onset, which often leads to severe disabilities.1 This disease type in lenticulostriate artery (LSA) is well known as branch atheromatous disease (BAD) in Japan.2 Neither evidence nor con sensus-based indications exist about how to prevent PMD2. Vascular risk factors, such as elevated haemoglobin A1c and blood pressure levels, as well as the characteristics of ischemic lesions, such as the size and location of the infarction, esp...
Source: Journal of Stroke and Cerebrovascular Diseases - March 10, 2021 Category: Neurology Authors: Ayaka Fujita, Masashi Matsuzaka, Norifumi Metoki, Joji Hagii, Hiroshi Shiroto, Manabu Iwata, Rina Tanaka, Eiichi Tsuda Source Type: research
Non-Dolichoectatic Vertebral Artery Compression of the Medulla: A Comprehensive Literature Review
This article presents the largest literature review to date on medullary compression of the vertebral arteries.
Source: Journal of Stroke and Cerebrovascular Diseases - March 31, 2021 Category: Neurology Authors: Cameron John Sabet Source Type: research
MiR-18a Aggravates Intracranial Hemorrhage by Regulating RUNX1-Occludin/ZO-1 Axis to Increase BBB Permeability
Every year, there are about 52,400 people suffered ICH in the USA.1 Approximately 15% of strokes result from a spontaneous ICH, which results in considerable disability and high mortality.2,3 There is not any effective treatment to prevent ICH-induced brain dysfunction. Significant progress has been made on the causes of BBB dysfunction after ICH at the molecular and cellular signaling level.4 There is increasing evidence that tight junction protein dysfunction contributes to the progression of ICH-induced secondary brain damage, leading to BBB disruption and cerebral edema.
Source: Journal of Stroke and Cerebrovascular Diseases - May 30, 2021 Category: Neurology Authors: Siying Ren, Guofeng Wu, Yuanxin Huang, Likun Wang, Yinghui Li, Yan Zhang Source Type: research
Systemic Inflammation Response Index and Systemic Immune-inflammation Index for Predicting the Prognosis of Patients with Aneurysmal Subarachnoid Hemorrhage
An aneurysmal subarachnoid hemorrhage (aSAH) can result in disability and high mortality.1 Re-bleeding, poor admission neurologic status, thick SAH, vasospasm, and delayed cerebral ischemia (DCI) are known as predicting factors for exacerbated prognosis of aSAH.2 –5 Similar to other cerebrovascular diseases, aSAH can causes a pronounced peripheral inflammatory/immune response. Systemic changes are also associated with outcomes of patients with SAH.6,7 Although the exact mechanism has not yet been fully revealed, inflammation is known to plays an important role in the progress of aSAH by inducing early brain damage, vasos...
Source: Journal of Stroke and Cerebrovascular Diseases - May 22, 2021 Category: Neurology Authors: Seonyong Yun, Ho Jun Yi, Dong Hoon Lee, Jae Hoon Sung Source Type: research
Sex Differences in the Relationship Between Arterial Stiffness and Cognitive Function in Older Adults
Currently, dementia is a public health priority. The World Health Organization estimates 50 million people worldwide have dementia and every year there are nearly 10 million new cases.1 Dementia is a major cause of disability and dependency among older adults.1 As such, a better understanding of the mechanisms underlying cognitive decline will aid in developing targeted therapies for treatment and prevention.
Source: Journal of Stroke and Cerebrovascular Diseases - October 26, 2021 Category: Neurology Authors: Elizabeth Dao, Cindy K. Barha, Mij Santos, Madison Welch, Teresa Liu-Ambrose Source Type: research
Endovascular thrombectomy is beneficial for functional nonagenarians – a multicenter cohort analysis
In recent years the use of endovascular thrombectomy (EVT) has dramatically increased mostly due to broader inclusive criteria.1,2 EVT use in octogenarians has become a common practice. However, data is still lacking regarding the safety and efficacy of EVT among nonagenarians. Nonagenarians suffering from a large vessel occlusion (LVO) were under-represented in randomized trials establishing the efficacy of EVT,3 and in recent trials assessing the effect of EVT in the extended time window.1,2 Patients above 90 years old represent a distinct population, as they tend to have more comorbidities, disabilities, and frailty.
Source: Journal of Stroke and Cerebrovascular Diseases - August 30, 2022 Category: Neurology Authors: Ofer Rotschild, Asaf Honig, Hen Hallevi, Anat Horev, Estelle Seyman, Einor Ben-Assayag, Tali Jonas-Kimchi, Udi Sadeh, Jose Cohen, Ronen R. Leker, Jeremy Molad Source Type: research
