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Impact of growth hormone-releasing hormone (GHRH) antagonist on Decidual stromal cell growth and apoptosis in vitro
Biol Reprod. 2021 Nov 18:ioab214. doi: 10.1093/biolre/ioab214. Online ahead of print.ABSTRACTEndometrial stromal cells remodeling is critical during human pregnancy. GHRH and its functional receptor have been shown to be expressed in gynecological cancer cells and eutopic endometrial stromal cells. Recent studies have demonstrated the potential clinical uses of antagonists of GHRH as effective antitumor agents because of its directly antagonistic effect on the locally produced GHRH in gynecological tumors. However, the impact of GHRH antagonists on normal endometrial stromal cell growth remained to be elucidated. The aim o...
Source: Biology of Reproduction - November 18, 2021 Category: Reproduction Medicine Authors: Hsien-Ming Wu Liang-Hsuan Chen Andrew V Schally Hong-Yuan Huang Yung-Kuei Soong Peter C K Leung Hsin-Shih Wang Source Type: research

Downregulation of decidual SKP2 is associated with human recurrent miscarriage
CONCLUSIONS: Our study indicates a functional role of SKP2 in RM: downregulation of SKP2 in RM leads to impaired decidualization and downregulation of GLUT1 and consequently predisposes individuals to RM.PMID:34116705 | DOI:10.1186/s12958-021-00775-4
Source: Reproductive Biology - June 12, 2021 Category: Reproduction Medicine Authors: Shijian Lv Mei Liu Lizhen Xu Cong Zhang Source Type: research

Thrombin impairs the angiogenic activity of extravillous trophoblast cells via monocyte chemotactic protein-1 (MCP-1): A possible link with preeclampsia
In conclusion, we propose that thrombin-controlled MCP-1 secretion may play an essential role in normal placental development and successful pregnancy maintenance. Improper thrombin production and MCP-1 secretion during pregnancy might cause inadequate vascular formation and transformation of spiral arteries, which may contribute to pregnancy disorders, such as preeclampsia.PMID:34058707 | DOI:10.1016/j.repbio.2021.100516
Source: Reproductive Biology - May 31, 2021 Category: Reproduction Medicine Authors: Daniela Br ünnert Vijay Kumar Vibha Kaushik Jens Ehrhardt Kirti Raj Chahar Phulwanti Kumari Sharma Marek Zygmunt Pankaj Goyal Source Type: research

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