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Electroacupuncture at Zusanli ameliorates the autistic-like behaviors of rats through activating the Nrf2-mediated antioxidant responses
CONCLUSION: These data suggested that electroacupuncture at ST36 protected nerve function in ASD rats through Nrf2 activation and the antioxidant response.PMID:35339642 | DOI:10.1016/j.gene.2022.146440
Source: Gene - March 27, 2022 Category: Genetics & Stem Cells Authors: Yong-Hong Zhao Hong-Guang Fu Hui Cheng Rui-Juan Zheng Guo Wang Sheng Li En-Yao Li Li-Guo Li Source Type: research

The Epidermal Growth Factor Receptor Critically Regulates Endometrial Function during Early Pregnancy
by Michael J. Large, Margeaux Wetendorf, Rainer B. Lanz, Sean M. Hartig, Chad J. Creighton, Michael A. Mancini, Ertug Kovanci, Kuo-Fen Lee, David W. Threadgill, John P. Lydon, Jae-Wook Jeong, Francesco J. DeMayo Infertility and adverse gynecological outcomes such as preeclampsia and miscarriage represent significant female reproductive health concerns. The spatiotemporal expression of growth factors indicates that they play an important role in pregnancy. The goal of this study is to define the role of the ERBB family of growth factor receptors in endometrial function. Using conditional ablation in mice and siRNA in prima...
Source: PLoS Genetics - June 19, 2014 Category: Genetics & Stem Cells Authors: Michael J. Large et al. Source Type: research

GSE95666 The Epidermal Growth Factor Receptor Critically Regulates Endometrial Function during Early Pregnancy
Contributor : Francesco DeMayoSeries Type : Expression profiling by arrayOrganism : Mus musculusInfertility and adverse gynecological outcomes such as preeclampsia and miscarriage represent significant female reproductive health concerns. The spatiotemporal expression of growth factors indicates that they play an important role in pregnancy. The goal of this study is to define the role of the ERBB family of growth factor receptors in endometrial function. Using conditional ablation in mice and siRNA in primary human endometrial stromal cells, we identified the epidermal growth factor receptor (Egfr) to be critical for endo...
Source: GEO: Gene Expression Omnibus - March 4, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research

Copy Number Variations Analysis Identifies QPRT as a Candidate Gene Associated With Susceptibility for Solitary Functioning Kidney
ConclusionOur data suggest that QPRT is a candidate gene associated with susceptibility for solitary functioning kidney. The CNVs discovered in our study exhibit great potential for future applications in genetic counseling and pregnancy management.
Source: Frontiers in Genetics - May 17, 2021 Category: Genetics & Stem Cells Source Type: research

HMOX1 Participates in Pre-Eclampsia by Regulating the Proliferation, Apoptosis, and Angiogenesis Modulation Potential of Mesenchymal Stem Cells via VEGF
Biochem Genet. 2023 Aug 12. doi: 10.1007/s10528-023-10474-x. Online ahead of print.ABSTRACTMesenchymal stem cells (MSCs) are involved in the pathogenesis of pre-eclampsia (PE). Heme oxygenase (HMOX) protects against placental cytotoxic injuries associated with PE. Here, we aimed to clarify the roles of HMOX1 in MSC proliferation and apoptosis, trophoblast cell migration, and regulation of angiogenesis, and assess its involvement in the pathogenesis of PE. HMOX1 and vascular endothelial growth factor (VEGF) expression levels in decidual tissues and decidua-derived MSCs (dMSCs) of healthy pregnant women and patients with PE ...
Source: Biochemical Genetics - August 12, 2023 Category: Genetics & Stem Cells Authors: Juan Shi Min Su Source Type: research