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025 * ablative maze surgery normalizes left ventricular function in patients with lone atrial fibrillation
Conclusions: Within a dedicated AF centre, ablative maze surgery grants excellent outcomes, with symptom relief and negligible risk. It provides a complete reversal of AF-related myocardial dysfunction and is therefore a convenient alternative to His bundle ablation and lifelong pacemaker dependency in symptomatic refractory patients.
Source: Interactive CardioVascular and Thoracic Surgery - September 18, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Pozzoli, A., Taramasso, M., Coppola, G., Kamami, M., La Canna, G., Della Bella, P., Alfieri, O., Benussi, S. Tags: Arrhythmia I Source Type: research

FDA Grants New Indication For Pfizer/Bristol Anticoagulant
The FDA has approved a new indication for apixaban (Eliquis), the anticoagulant drug manufactured by Bristol-Myers Squibb and Pfizer. The new indication is for the prophylaxis of deep vein thrombosis (DVT) in patients who have undergone hip or knee replacement surgery. DVT can lead to the life-threatening condition of pulmonary embolism (PE). The DVT prophylaxis indication joins the previously approved indication of stroke prevention in patients who have nonvalvular atrial fibrillation.
Source: Forbes.com Healthcare News - March 14, 2014 Category: Pharmaceuticals Authors: Larry Husten Source Type: news

Maze surgery normalizes left ventricular function in patients with persistent lone atrial fibrillation ADULT CARDIAC
CONCLUSIONS Within a dedicated AF centre, maze surgery grants excellent outcomes, with symptoms relief and negligible risk. It provides a complete reversal of arrhythmia-related myocardial dysfunction and is therefore a convenient alternative to His bundle ablation and lifelong pacemaker dependency in symptomatic refractory patients.
Source: European Journal of Cardio-Thoracic Surgery - October 10, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Pozzoli, A., Taramasso, M., Coppola, G., Kamami, M., La Canna, G., Bella, P. D., Alfieri, O., Benussi, S. Tags: Minimally invasive surgery, Myocardial infarction, Myocardial protection, Transplantation - heart ADULT CARDIAC Source Type: research

UNC lands $1.7M grant from Bristol-Myers Squibb
The UNC School of Medicine has landed a $1.7 million grant from the Bristol-Myers Squibb Foundation – aimed at improving care and education for patients with atrial fibrillation (Afib), or an irregular heartbeat that can lead to stroke and heart failure, among other complications. The three-year grant will be used by cardiologist Dr. Anil Gehi to further a care model he launched back in 2015. A ccording to UNC, Gehi's work has reduced hospitalizations for Afib patients in the emergency room by…
Source: bizjournals.com Health Care:Physician Practices headlines - September 29, 2017 Category: American Health Authors: Jennifer Henderson Source Type: news

Cooper gets $982K to combat disparities in heart care
The Bristol-Myers Squibb Foundation is providing a $982,000 grant to support a project by Cooper University Health Care ’s Urban Health Institute to address disparities in heart care. The initiative, called "Reducing Disparities in Cardiovascular Care through Optimization of Risk Factors in Vulnerable Populations," will: The project will target Medicaid patients from Camden and the surrounding region with a his tory of atrial fibrillation, heart attack or stroke, who are failing medical treatment…
Source: bizjournals.com Health Care:Biotechnology headlines - January 16, 2018 Category: Biotechnology Authors: John George Source Type: news

Atrial Transcriptional Profiles of Molecular Targets Mediating Electrophysiological Function in Aging and Pgc-1 β Deficient Murine Hearts
Conclusion: These findings limit the possible roles of gene transcriptional changes in previously reported age-dependent pro-arrhythmic electrophysiologial changes observed in Pgc-1β-/- atria to an altered Ca2+-ATPase (Atp2a2) expression. This directly parallels previously reported arrhythmic mechanism associated with p21-activated kinase type 1 deficiency. This could add to contributions from the direct physiological outcomes of mitochondrial dysfunction, whether through reactive oxygen species (ROS) production or altered Ca2+ homeostasis. Introduction Atrial arrhythmias constitute a major public health pro...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Po-641-05 safety and in-hospital outcomes of left atrial appendage closure device in patients with heart failure: an analysis from the national inpatient sample database 2015-2018
Left atrial appendage occlusion (LAAO) is a procedure that has been shown to be non-inferior to oral anticoagulation for stroke prevention for patients with atrial fibrillation. There is limited data about the safety of left atrial appendage occlusion (LAAO) in patients with heart failure (HF).
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Carlos Vergara Sanchez, Michael Dangl, Michael Albosta, Ian Ergui, Karla Inestroza, Jennifer Maning, Louis Thomas Vincent, Jelani K. Grant, Bertrand Ebner, Rosario Colombo Source Type: research

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