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Condition: Arteriosclerosis

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Total 577 results found since Jan 2013.

Redundancy and Interaction of Thrombin- and Collagen-Mediated Platelet Activation in Tail Bleeding and Carotid Thrombosis in Mice.
CONCLUSIONS: The observation that loss of Par4 uncovered large effects of GPVI deficiency implies that Par4 and GPVI made independent, partially redundant contributions to occlusive thrombus formation in the carotid and to hemostatic clot formation in the tail under the experimental conditions examined. At face value, these results suggest that thrombin- and collagen-induced platelet activation can play partially redundant roles, despite important differences in how these agonists are made available to platelets. PMID: 25278288 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 2, 2014 Category: Cardiology Authors: Bynagari-Settipalli YS, Cornelissen I, Palmer D, Duong D, Concengco C, Ware J, Coughlin SR Tags: Arterioscler Thromb Vasc Biol Source Type: research

Heme Oxygenase-1 Gene Promoter Microsatellite Polymorphism Is Associated With Progressive Atherosclerosis and Incident Cardiovascular Disease.
CONCLUSIONS: This study found a strong association between the HO-1 variable number tandem repeat polymorphism and cardiovascular disease risk confined to subjects with a high number of repeats on both HO-1 alleles and provides evidence for accelerated atherogenesis and decreased antioxidant defense in this vascular high-risk group. PMID: 25359861 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 30, 2014 Category: Cardiology Authors: Pechlaner R, Willeit P, Summerer M, Santer P, Egger G, Kronenberg F, Demetz E, Weiss G, Tsimikas S, Witztum JL, Willeit K, Iglseder B, Paulweber B, Kedenko L, Haun M, Meisinger C, Gieger C, Müller-Nurasyid M, Peters A, Willeit J, Kiechl S Tags: Arterioscler Thromb Vasc Biol Source Type: research

Well: Ask Well: Blockages in the Heart and Brain
A reader asks: Why do people get blockages in the arteries of the heart and brain, but rarely in other organs?
Source: NYT - January 5, 2015 Category: American Health Authors: By ANAHAD O'CONNOR Tags: Heart Body Brain Stroke Arteriosclerosis and Atherosclerosis Featured Source Type: news

Ask Well: Blockages in the Heart and Brain
A reader asks: Why do people get blockages in the arteries of the heart and brain, but rarely in other organs?
Source: NYT Health - January 5, 2015 Category: Consumer Health News Authors: By ANAHAD O'CONNOR Tags: Heart Body Brain Stroke Arteriosclerosis and Atherosclerosis Featured Source Type: news

Circulating Total Bilirubin and Risk of Incident Cardiovascular Disease in the General Population.
CONCLUSIONS: There is a log-linear inverse association between circulating total bilirubin level and CVD risk, which is independent of established risk factors. Nonetheless, inclusion of total bilirubin in the standard established risk factors panel provides no significant improvement in CVD risk prediction. PMID: 25593130 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 15, 2015 Category: Cardiology Authors: Kunutsor SK, Bakker SJ, Gansevoort RT, Chowdhury R, Dullaart RP Tags: Arterioscler Thromb Vasc Biol Source Type: research

Persimmon (Diospyros kaki L.) leaves: A review on traditional uses, phytochemistry and pharmacological properties
Conclusions Persimmon leaves probably have therapeutic potential in the prevention and treatment for cerebral arteriosclerosis, diabetes, hypertension. It showed significant neuroprotection against ischemia/reperfusion injury in vivo and in vitro. Moreover, it can regulate immune function and inhibite inflammation. Further investigations are needed to explore individual bioactive compounds responsible for these pharmacological effects in vitro and in vivo and the mode of actions. Further safety assessments and clinical trials should be performed before it can be integrated into medicinal practices. Graphical abstract
Source: Journal of Ethnopharmacology - February 21, 2015 Category: Drugs & Pharmacology Source Type: research

Vascular Smooth Muscle Cells Are Responsible for a Prothrombotic Phenotype of Spontaneously Hypertensive Rat Arteries.
CONCLUSIONS: The prothrombotic phenotype of the SHR vessel wall was because of the ability of SMCs to support greater thrombin generation and resulted in accelerated occlusive thrombus formation after arterial injury, which was sensitive to glycoprotein Ibα-von Willebrand factor inhibitors. PMID: 25722431 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 26, 2015 Category: Cardiology Authors: Aissa KA, Lagrange J, Mohamadi A, Louis H, Houppert B, Challande P, Wahl D, Lacolley P, Regnault V Tags: Arterioscler Thromb Vasc Biol Source Type: research

Overview of the New Oral Anticoagulants: Opportunities and Challenges.
Abstract The non-vitamin K oral anticoagulants (NOACs) are replacing warfarin for many indications. These agents include dabigatran, which inhibits thrombin, and rivaroxaban, apixaban, and edoxaban, which inhibit factor Xa. All the 4 agents are licensed in the United States for stroke prevention in atrial fibrillation and for treatment of venous thromboembolism and rivaroxaban and apixaban are approved for thromboprophylaxis after elective hip or knee arthroplasty. The NOACs are at least as effective as warfarin, but are not only more convenient to administer because they can be given in fixed doses without routin...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 19, 2015 Category: Cardiology Authors: Yeh CH, Hogg K, Weitz JI Tags: Arterioscler Thromb Vasc Biol Source Type: research

C‐reactive protein levels are associated with cerebral small vessel‐related lesions
ConclusionsHigher levels of hs‐CRP were associated with lacunar infarcts. Thus, inflammatory processes may be involved in the pathogenesis of small‐vessel disease.
Source: Acta Neurologica Scandinavica - May 15, 2015 Category: Neurology Authors: S. Mitaki, A. Nagai, H. Oguro, S. Yamaguchi Tags: Original Article Source Type: research

64Cu-DOTATATE PET/MRI for Detection of Activated Macrophages in Carotid Atherosclerotic Plaques: Studies in Patients Undergoing Endarterectomy.
CONCLUSIONS: The novel PET tracer (64)Cu-DOTATATE accumulates in atherosclerotic plaques of the carotid artery. CD163 gene expression correlated independently with (64)Cu-DOTATATE uptake measured by real-time quantitative polymerase chain reaction in the final multivariate model, indicating that (64)Cu-DOTATATE PET is detecting alternatively activated macrophages. This association could potentially improve noninvasive identification and characterization of vulnerable plaques. PMID: 25977567 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 14, 2015 Category: Cardiology Authors: Folke Pedersen S, Vikjær Sandholt B, Høgild Keller S, Espe Hansen A, Ettrup Clemmensen A, Sillesen H, Højgaard L, Sejersten Ripa R, Kjær A Tags: Arterioscler Thromb Vasc Biol Source Type: research

Light and Dark of Reactive Oxygen Species for Vascular Function: 2014 ASVB (Asian Society of Vascular Biology)
Abstract: Vascular-derived hydrogen peroxide (H2O2) serves as an important signaling molecule in the cardiovascular system and contributes to vascular homeostasis. H2O2 is a second messenger, transducing the oxidative signal into biological responses through posttranslational protein modification. The balance between oxidant and antioxidant systems regulates intracellular redox status, and their imbalance causes oxidative or reductive stress, leading to cellular damage in cardiovascular systems. Excessive H2O2 deteriorates vascular functions and promotes vascular disease through multiple pathways. The RhoA/Rho-kinase pathw...
Source: Journal of Cardiovascular Pharmacology - May 1, 2015 Category: Cardiology Tags: Highlighted Meetings Article Source Type: research

Both MC1 and MC3 Receptors Provide Protection From Cerebral Ischemia-Reperfusion-Induced Neutrophil Recruitment.
CONCLUSIONS: These studies reveal for the first time MC control for neutrophil recruitment in the unique pathophysiological context of cerebral I/R, while also demonstrating the potential therapeutic value of targeting multiple MCs in developing effective therapeutics. PMID: 26112010 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 25, 2015 Category: Cardiology Authors: Holloway PM, Durrenberger PF, Trutschl M, Cvek U, Cooper D, Orr AW, Perretti M, Getting SJ, Gavins FN Tags: Arterioscler Thromb Vasc Biol Source Type: research

Gallstone Disease and the Risk of Ischemic Heart Disease.
CONCLUSIONS: In this large prospective study, the presence of GSD was associated with an increased risk of incident IHD, independent of other risk factors of cardiovascular disease. Our findings suggest novel prevention strategy to mitigate heart disease through improvement of gastrointestinal health. PMID: 26272939 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 13, 2015 Category: Cardiology Authors: Lv J, Qi L, Yu C, Guo Y, Bian Z, Chen Y, Yang L, Shen J, Wang S, Li M, Liu Y, Zhang L, Chen J, Chen Z, Li L Tags: Arterioscler Thromb Vasc Biol Source Type: research