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Condition: Arteriosclerosis
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Total 89 results found since Jan 2013.
Musclin Mitigates the Attachment of HUVECs to THP-1 Monocytes in Hyperlipidemic Conditions through PPAR α/HO-1-Mediated Attenuation of Inflammation
This study aimed to explore the impact of musclin on inflammatory responses and the interaction between endothelial cells and monocytes under hyperlipidemic conditions. The attachment levels of THP-1 monocytes on cultured HUVECs were examined. Inflammation and the expression of cell adhesion molecules were also evaluated. To explore the molecular mechanisms of musclin, PPAR α or heme oxygenase 1 (HO-1) siRNA transfection was performed in HUVECs. The results revealed that treatment with recombinant musclin effectively suppressed the attachment of palmitate-induced HUVECs to THP-1 cells and reduced the expression of cell ad...
Source: Inflammation - September 22, 2023 Category: Allergy & Immunology Source Type: research
Endothelial TIE1 Restricts Angiogenic Sprouting to Coordinate Vein Assembly in Synergy With Its Homologue TIE2
CONCLUSIONS: Findings from this study imply that TIE1 and TIE2, together with COUP-TFII, act in a synergistic manner to restrict sprouting angiogenesis during the development of venous system.PMID:37317851 | DOI:10.1161/ATVBAHA.122.318860
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 15, 2023 Category: Cardiology Authors: Xudong Cao Taotao Li Beibei Xu Kai Ding Weimin Li Bin Shen Man Chu Dengwen Zhu Li Rui Zhi Shang Xiao Li Yinyin Wang Shuyu Zheng Kari Alitalo Ganqiang Liu Jing Tang Yoshiaki Kubota Yulong He Source Type: research
Endothelial PHACTR1 Promotes Endothelial Activation and Atherosclerosis by Repressing PPAR γ Activity Under Disturbed Flow in Mice
CONCLUSIONS: Our results identified endothelial PHACTR1 as a novel PPARγ corepressor to promote atherosclerosis in disturbed flow regions. Endothelial PHACTR1 is a potential therapeutic target for atherosclerosis treatment.PMID:37199156 | DOI:10.1161/ATVBAHA.122.318173
Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 18, 2023 Category: Cardiology Authors: Dongyang Jiang Hao Liu Guofu Zhu Xiankai Li Linlin Fan Faxue Zhao Chong Xu Shumin Wang Yara Rose Jordan Rhen Ze Yu Yiheng Yin Yuling Gu Xiangbin Xu Edward A Fisher Junbo Ge Yawei Xu Jinjiang Pang Source Type: research
EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy
CONCLUSIONS: We identified EVA1A as a novel flow-sensitive gene that mediates the effects of proatherogenic DF on EC dysfunction by regulating autophagy.PMID:36794585 | DOI:10.1161/ATVBAHA.122.318110
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 16, 2023 Category: Cardiology Authors: Lindsay Canham Sam Sendac Mannekomba R Diagbouga Elena Wolodimeroff Daniela Pirri Blanca Tardajos Ayllon Shuang Feng Celine Souilhol Timothy J A Chico Paul C Evans Jovana Serbanovic-Canic Source Type: research
