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Clinical Characteristics and Outcomes of Chagas Disease in the United States: A Multicenter Retrospective Analysis
Am J Trop Med Hyg. 2023 Sep 11:tpmd230361. doi: 10.4269/ajtmh.23-0361. Online ahead of print.ABSTRACTChagas disease affects approximately 300,000 patients in the United States. We evaluated a multicenter U.S.-based network to obtain clinical characteristics and outcomes of chronic Chagas disease by disease forms. This was a U.S.-based, multicenter, population-based, retrospective cohort study. We queried TriNetX, a global research network, to identify patients with dual-positive IgG serology for Trypanosoma cruzi. We captured outcomes of interest for up to 5 years. We found 429 patients with evidence of dual-positive T. cr...
Source: Am J Trop Med Hyg - September 11, 2023 Category: Infectious Diseases Authors: Andr és F Henao-Martínez Christian Olivo-Freites Nelson I Agudelo Higuita Carolina Ferraz Carlos Franco-Paredes Jose Tuells Laila Woc-Colburn Salvador Villalpando-Carri ón Daniel B Chastain Anis Rassi Source Type: research

Platelets, Macrophages, and Thromboinflammation in Chagas Disease
J Inflamm Res. 2022 Oct 4;15:5689-5706. doi: 10.2147/JIR.S380896. eCollection 2022.ABSTRACTChagas disease (CD) is a major health problem in the Americas and an emerging health problem in Europe and other nonendemic countries. Several studies have documented persistence of the protozoan parasite Trypanosoma cruzi, and oxidative and inflammatory stress are major pathogenic factor. Mural and cardiac thrombi, cardiac arrhythmias, and cardiomyopathy are major clinical features of CD. During T. cruzi infection, parasite-released factors induce endothelial dysfunction along with platelet (PLT) and immune-cell activation. PLTs hav...
Source: Cell Research - October 11, 2022 Category: Cytology Authors: Subhadip Choudhuri Nisha J Garg Source Type: research

Dobutamine Stress Echocardiography Safety in Chagas Disease Patients
Conclusion: DSE proved to be safe in this population of Chagas disease patients, in which no potentially life-threatening outcome was found.Resumo Fundamento: At é poucas décadas atrás, os pacientes chagásicos eram predominantemente trabalhadores rurais, com baixo perfil de risco para doença obstrutiva coronária. Com a crescente urbanização, passaram a ter os mesmos fatores de risco para doença aterosclerótica que indivíduos não infectados. O eco cardiograma sob estresse com dobutamina (EED) é uma importante ferramenta no diagnóstico de coronariopatia. É referido, porém, como um método potencialmente arrit...
Source: Arquivos Brasileiros de Cardiologia - March 20, 2017 Category: Cardiology Source Type: research