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Relation Between Stroke Volume Index to Risk of Death in Patients With Low-Gradient Severe Aortic Stenosis and Preserved Left Ventricular Function
Source: The American Journal of Cardiology - May 16, 2014 Category: Cardiology Authors: Elad Maor, Roy Beigel, Avishay Grupper, Rafael Kuperstein, Ilan Hai, Diego Medvedofsky, Olga Perelstein, Israel Mazin, Asaf Ziv, Ilan Goldenberg, Micha S. Feinberg, Sagit Ben Zekry Tags: Valvular Heart Disease Source Type: research

Impact of Flow and Left Ventricular Strain on Outcome of Patients With Preserved Left Ventricular Ejection Fraction and Low Gradient Severe Aortic Stenosis Undergoing Aortic Valve Replacement
The prognostic implications of flow, assessed by stroke volume index (SVi), and left ventricular (LV) global longitudinal strain on survival of patients with low-gradient severe aortic stenosis (AS) and preserved LV ejection fraction are debated. The aim of this study was to evaluate the impact of flow and LV global longitudinal strain on survival in these patients treated with aortic valve replacement (AVR). Patients with low-gradient severe AS with preserved LV ejection fraction treated with AVR (n = 134, mean age 76 ± 10 years, 50% men) were included in the present study.
Source: The American Journal of Cardiology - September 25, 2014 Category: Cardiology Authors: Vasileios Kamperidis, Philippe J. van Rosendael, Arnold C.T. Ng, Spyridon Katsanos, Frank van der Kley, Philippe Debonnaire, Emer Joyce, Georgios Sianos, Nina Ajmone Marsan, Jeroen J. Bax, Victoria Delgado Tags: Valvular Heart Disease Source Type: research

Is Transcatheter Aortic Valve Implantation as Cost-effective as Surgical Aortic Valve Replacement?
Transcatheter aortic valve implantation (TAVI) has emerged as an efficacious and cost-effective treatment for inoperable patients with severe aortic stenosis.1 For high-risk patients, existing evidence suggests that TAVI has similar peri-procedural mortality and stroke outcomes compared to surgical aortic valve replacement (AVR), with higher incidences of paravalvular leak, permanent pacemaker requirement and vascular injuries after TAVI and higher incidences of major bleeding after AVR.2 Regarding the cost-effectiveness of TAVI, a recent systematic review examining its incremental cost effectiveness ratio in relation to A...
Source: The American Journal of Cardiology - July 16, 2015 Category: Cardiology Authors: Christopher Cao Source Type: research

Meta-analysis of Transcatheter Aortic Valve Replacement Versus Surgical Aortic Valve Replacement in patients with Severe Aortic Valve Stenosis Patients
Transcatheter aortic valve replacement (TAVR) is a viable option in the treatment of severe aortic stenosis in patients at high risk for surgery. We sought to further investigate outcomes in low-to-intermediate-risk patients with aortic stenosis undergoing surgical aortic valve replacement (SAVR) versus TAVR. We systematically searched the electronic databases, MEDLINE, PUBMED, EMBASE and Cochrane for prospective cohort studies of the effects of TAVR vs SAVR on clinical outcomes (30-day mortality, all cause mortality, stroke and myocardial infarction [MI], major vascular complications, paravalvular regurgitation, permanent...
Source: The American Journal of Cardiology - November 5, 2015 Category: Cardiology Authors: Ashok Kondur, Alexandros Briasoulis, Mohan Palla, Anirudh Penumetcha, Sagar Mallikethi-Reddy, Apurva Badheka, Theodore Schreiber Source Type: research

Reliability of Aortic Stenosis Severity Classified by 3-Dimensional Echocardiography in the Prediction of Cardiovascular Events
The estimation of aortic valve area (AVA) by Doppler echocardiography-derived left ventricular stroke volume (LVSV) remains controversial. We hypothesized that AVA estimated from directly measured LVSV by 3-dimensional echocardiography (3DE) on the continuity equation might be more accurate in classifying aortic stenosis (AS) severity. We retrospectively enrolled 265 patients with moderate to severe AS with preserved ejection fraction. Indexed AVA (iAVA) was calculated using LVSV derived by 2D-Doppler (iAVADop), Simpson’s method (iAVASimp), and 3DE (iAVA3D).
Source: The American Journal of Cardiology - May 13, 2016 Category: Cardiology Authors: Kimi Sato, Yoshihiro Seo, Tomoko Ishizu, Hideki Nakajima, Masaaki Takeuchi, Masaki Izumo, Kengo Suzuki, Yoshihiro J. Akashi, Yutaka Otsuji, Kazutaka Aonuma Source Type: research

Transcatheter Aortic Valve Implantation Futility Risk Model Development and Validation among Treated Patients with Aortic Stenosis Patients
Risk-benefit assessment for transcatheter aortic valve implantation (TAVI) is still evolving. A sizeable group of patients do not fully benefit from intervention despite technically successful procedure. All patients who underwent TAVI with device success and with no VARC-2 defined complications were included. Various demographic data, clinical details and echocardiographic findings were examined. The outcome was defined as 1-year composite of mortality, stroke, lack of functional-class improvement (by NYHA class), and readmissions ( ≥1 month post procedure).
Source: The American Journal of Cardiology - September 15, 2017 Category: Cardiology Authors: Oren Zusman, Ran Kornowski, Guy Witberg, Adi Lador, Katia Orvin, Amos Levi, Abid Assali, Hana Vaknin-Assa, Ram Sharony, Yaron Shapira, Alexander Sagie, Uri Landes Source Type: research

Usefulness of the CHA2DS2-Vasc Score to Predict Outcome in Patients Undergoing Transcatheter Aortic Valve Implantation
Risk assessment for transcatheter aortic valve implantation (TAVI) patients remains challenging, especially among elderly and high-risk candidates. Although several risk factors contribute to increased morbidity and mortality following TAVI, simple risk scores for routine use are lacking. Applying the CHA2DS2-VASC score as a novel risk stratification tool for conditions other than atrial fibrillation (AF) and stroke prevention has been previously examined; however, its usefulness in a population of patients with aortic stenosis following TAVI has not been established.
Source: The American Journal of Cardiology - October 19, 2017 Category: Cardiology Authors: Katia Orvin, Amos Levi, Uri Landes, Tamir Bental, Alexander Sagie, Yaron Shapira, Hana Vaknin-Assa, Abid Assali, Ran Kornowski Source Type: research

Temporal-Trends in Sex-Related Differences and Outcomes in Patients Undergoing Transcatheter Aortic Valve Implantation (From the Israeli TAVI Multicentre Registry)
We evaluated temporal trends in sex-related differences in patients undergoing trans-catheter aortic valve implantation (TAVI) for severe symptomatic aortic stenosis (AS) from a multicentre TAVI registry during the years 2008-2016. Our final cohort included 1,159 males and 1,370 females, with a median follow-up of 2.3 (IQR 1.2, 4.4) years. For temporal trends analysis, the entire population was divided according to period of procedure: 2008-2012 and 2013-2016. During the 2008-2012 period, the rates of in-hospital aortic paravalvular leak, myocardial infarction, pacemaker implantation, and stroke were higher among males tha...
Source: The American Journal of Cardiology - October 3, 2018 Category: Cardiology Authors: Osnat Itzhaki Ben Zadok, Ran Kornowski, Ariel Finkelstein, Israel Barbash, Haim Danenberg, Amit Segev, Victor Guetta, Amir Halkin, Hana Vaknin, David Planer, Abid Assali, Alon Barsheshet, Katia Orvin Source Type: research

Temporal Trends in Gender-Related Differences and Outcomes in Patients Who Underwent Transcatheter Aortic Valve Implantation (from the Israeli Transcatheter Aortic Valve Implantation Multicenter Registry)
We evaluated temporal trends in gender-related differences in patients who underwent transcatheter aortic valve implantation (TAVI) for severe symptomatic aortic stenosis from a multicenter TAVI registry during the years 2008 to 2016. Our final cohort included 1,159 males and 1,370 females, with a median follow-up of 2.3 (IQR 1.2, 4.4) years. For temporal trends analysis, the entire population was divided according to period of procedure: 2008 to 2012 and 2013 to 2016. During the 2008 to 2012 period, the rates of in-hospital aortic paravalvular leak, myocardial infarction, pacemaker implantation, and stroke were higher amo...
Source: The American Journal of Cardiology - October 3, 2018 Category: Cardiology Authors: Osnat Itzhaki Ben Zadok, Ran Kornowski, Ariel Finkelstein, Israel Barbash, Haim Danenberg, Amit Segev, Victor Guetta, Amir Halkin, Hana Vaknin, David Planer, Abid Assali, Alon Barsheshet, Katia Orvin Source Type: research

Relation of Body-Mass Index to Risk of Death or Stroke Among Patients Undergoing Transcatheter Aortic Valve Implantation
Obesity and overweight have been associated with better clinical outcomes in different populations with a diverse spectrum of cardiovascular disease ( “obesity paradox”). However, conflicting data exist about the relation between BMI and outcomes after transcatheter aortic valve implantation (TAVI). The aim of this study is to evaluate the association of body mass index (BMI) with clinical outcomes in patients with severe aortic stenosis (AS) undergoing TAVI. The study cohort included 379 consecutive patients with symptomatic severe AS who underwent TAVI between March 2010 and February 2017 in 3 centers in East Asia.
Source: The American Journal of Cardiology - November 24, 2018 Category: Cardiology Authors: Sang Yong Om, Euihong Ko, Jung-Min Ahn, Do-Yoon Kang, Kyusup Lee, Osung Kwon, Pil Hyung Lee, Seung-Whan Lee, Ho Jin Kim, Joon Bum Kim, Suk Jung Choo, Duk-Woo Park, Seung-Jung Park Source Type: research

Relation of Body Mass Index to Risk of Death or Stroke in Patients Who Underwent Transcatheter Aortic Valve Implantation
Obesity and overweight have been associated with better clinical outcomes in different populations with a diverse spectrum of cardiovascular disease (obesity paradox). However, conflicting data exist about the relation between body mass index (BMI) and outcomes after transcatheter aortic valve implantation (TAVI). The aim of this study is to evaluate the association of body mass index with clinical outcomes in patients with severe aortic stenosis (AS) who underwent TAVI. The study cohort included 379 consecutive patients with symptomatic severe AS who underwent TAVI between March 2010 and February 2017 in 3 centers in East Asia.
Source: The American Journal of Cardiology - November 24, 2018 Category: Cardiology Authors: Sang Yong Om, Euihong Ko, Jung-Min Ahn, Do-Yoon Kang, Kyusup Lee, Osung Kwon, Pil Hyung Lee, Seung-Whan Lee, Ho Jin Kim, Joon Bum Kim, Suk Jung Choo, Duk-Woo Park, Seung-Jung Park Source Type: research

Meta-Analysis Comparing Results of Transcatheter versus Surgical Aortic-Valve Replacement in Patients with Severe Aortic Stenosis
Transcatheter aortic-valve replacement (TAVR) has emerged as a promising strategy for treating patients with severe aortic stenosis. We aimed to compare TAVR with surgical aortic-valve replacement (SAVR) and determine the performance of TAVR over time and within several subgroups. We included 8 randomized trials comparing TAVR vs. SAVR. Compared with SAVR, TAVR was associated with a lower rate of all-cause mortality or disabling stroke at 30-day (odds ratio [OR], 0.72; P=0.004), 1-year (OR, 0.83; P=0.01) and 2-year (OR, 0.86; P=0.02), but not at long-term follow-up (rate ratio [RR], 1.02 [CI, 0.92 to 1.13]; P=0.67).
Source: The American Journal of Cardiology - November 6, 2019 Category: Cardiology Authors: Xinlin Zhang, Tingyu Wang, Rongfang Lan, Qing Dai, Lina Kang, Lian Wang, Yong Wang, Wei Xu, Biao Xu Source Type: research

Long-term Follow-up of Transcatheter Aortic Valve Implantation with Portico vs. Evolut devices
New-generation devices such as Evolut and Portico have provided favorable results in patients undergoing transcatheter aortic valve implantation (TAVI) for aortic stenosis, but their comparative effectiveness remains debated, despite its relevance when envisioning TAVI in low-risk patients. We evaluated the safety and efficacy of 2 leading TAVI devices (Evolut and Portico) used by the same team of experienced TAVI operators, focusing long-term outcomes, including the major adverse events (i.e. the composite of death, stroke, myocardial infarction, major vascular complication or major bleeding).
Source: The American Journal of Cardiology - January 28, 2020 Category: Cardiology Authors: Nicola Corcione, Giuseppe Biondi-Zoccai, Paolo Ferraro, Alberto Morello, Sirio Conte, Michele Cimmino, Carlo Vigna, Giacomo Frati, Giovanni De Persio, Luca Altamura, Fabrizio Tomai, Andrea Berni, Mauro Cassese, Martino Pepe, Arturo Giordano Source Type: research

Long-Term Follow-Up of Transcatheter Aortic Valve Implantation With Portico Versus Evolut Devices
New-generation devices such as Evolut and Portico have provided favorable results in patients who underwent transcatheter aortic valve implantation (TAVI) for aortic stenosis, but their comparative effectiveness remains debated, despite its relevance when envisioning TAVI in low-risk patients. We evaluated the safety and efficacy of 2 leading TAVI devices (Evolut and Portico) used by the same team of experienced TAVI operators, focusing on long-term outcomes, including major adverse events (i.e., the composite of death, stroke, myocardial infarction, major vascular complication, or major bleeding).
Source: The American Journal of Cardiology - January 28, 2020 Category: Cardiology Authors: Nicola Corcione, Giuseppe Biondi-Zoccai, Paolo Ferraro, Alberto Morello, Sirio Conte, Michele Cimmino, Carlo Vigna, Giacomo Frati, Giovanni De Persio, Luca Altamura, Fabrizio Tomai, Andrea Berni, Mauro Cassese, Martino Pepe, Arturo Giordano Source Type: research

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