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Low dose tPA plus annexin A2 combination attenuates tPA delayed treatment- associated hemorrhage and improves recovery in rat embolic focal stroke
In conclusion, compared to conventional tPA alone, when treated at delayed 4-hour after stroke, the combination of low-dose tPA plus rA2 therapy provides a safer profile by lowering risk of ICH transformation and improves neurological function recovery after stroke.
Source: Neuroscience Letters - July 10, 2015 Category: Neuroscience Source Type: research

A study of ER stress in rat model of cerebral venous sinus thrombosis
Publication date: 4 March 2015 Source:Neuroscience Letters, Volume 589 Author(s): Hari Shanker Tiwari , Amit Kumar Tripathi , Durga Prasad Mishra , Jayantee Kalita , Usha Kant Misra Cerebral venous sinus thrombosis (CVST) is a rare form of stroke. The role of endoplasmic reticulum (ER) stress markers is well documented in arterial stroke but has not been evaluated in venous stroke. The present study has been undertaken to investigate the role of ER stress in rodent model of CVST. For inducing CVST, a cranial window was made to expose superior sagittal sinus (SSS). A strip of filter paper soaked with 40% ferric chloride w...
Source: Neuroscience Letters - January 25, 2015 Category: Neuroscience Source Type: research

Neurologic complications in children under five years with Sickle Cell Disease
ConclusionNeurologic complications in children under five years of age with SCD may be more frequent than currently reported, among which Silent cerebral infarct and cognitive impairment are the most common.
Source: Neuroscience Letters - April 28, 2019 Category: Neuroscience Source Type: research

Inhibition of PI3Kγ by AS605240 plus low-dose tissue plasminogen activator (tPA) combination improves thrombolytic therapy in a rat model of embolic stroke
Publication date: Available online 31 August 2020Source: Neuroscience LettersAuthor(s): Rong Jin, Wei Zhong, Shan Liu, Min Wang, Guohong Li
Source: Neuroscience Letters - September 1, 2020 Category: Neuroscience Source Type: research