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Thrombus-associated microbiota in acute ischemic stroke patients
CONCLUSION: In this small study, we demonstrate proof of concept and technical feasibility for amplicon-based metagenomic sequencing of arterial thrombi and briefly discuss preliminary findings, challenges, and near-term translational opportunities for thrombus genomics.PMID:35855159 | PMC:PMC9282817 | DOI:10.25259/SNI_104_2022
Source: Surgical Neurology International - July 20, 2022 Category: Neurosurgery Authors: Melanie Walker Carla Uranga Samuel Hs Levy Cory Kelly Anna Edlund Source Type: research

Stroke outcome of early antiplatelet in post-thrombolysis haemorrhagic infarction
Conclusions Antiplatelet therapy can be safely used between 24 and 48 hours when HI occurs after IVT, and such therapy is associated with reduced risk of END and improved neurological outcome in patients who had an AIS.
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 14, 2022 Category: Neurosurgery Authors: Zhong, W., Yan, S., Chen, Z., Luo, Z., Chen, Y., Zhang, X., Wu, C., Tang, W., Zhang, X., Wang, Y., Gu, Q., Xu, D., Chen, H., Lou, M., on behalf of the CASE-II Study Group Tags: Cerebrovascular disease Source Type: research

IVIg-exposure and thromboembolic event risk: findings from the UK Biobank
Background Arterial and venous thromboembolic events (TEEs) have been associated with intravenous Ig use, but the risk has been poorly quantified. We aimed to calculate the risk of TEEs associated with exposure to intravenous Ig. Methods We included participants from UK Biobank recruited over 3 years, data extracted September 2020. The study endpoints were incidence of myocardial infarction, other acute ischaemic heart disease, stroke, pulmonary embolism and other venous embolism and thrombosis. Predictors included known TEE risk factors: age, sex, hypertension, smoking status, type 2 diabetes mellitus, hypercholesterolae...
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 14, 2022 Category: Neurosurgery Authors: Kapoor, M., Hunt, I., Spillane, J., Bonnett, L. J., Hutton, E. J., McFadyen, J., Westwood, J.-P., Lunn, M. P., Carr, A. S., Reilly, M. M. Tags: Neuromuscular Source Type: research

Thrombectomy for secondary distal, medium vessel occlusions of the posterior circulation: seeking complete reperfusion
Conclusion Thrombectomy for secondary posterior circulation DMVO seems to be safe and technically feasible. Even though thrombi that have migrated preprocedurally may be easier to retract, successful reperfusion can be achieved in the majority of patients with secondary DMVO of the P2 and P3 segment.
Source: Journal of NeuroInterventional Surgery - June 16, 2022 Category: Neurosurgery Authors: Meyer, L., Stracke, C. P., Wallocha, M., Broocks, G., Sporns, P. B., Piechowiak, E. I., Kaesmacher, J., Maegerlein, C., Dorn, F., Zimmermann, H., Naziri, W., Abdullayev, N., Kabbasch, C., Behme, D., Jamous, A., Maus, V., Fischer, S., Möhlenbruch, Tags: Ischemic stroke Source Type: research

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