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Condition: Thrombosis
Drug: Insulin
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Total 233 results found since Jan 2013.
Pannexin 1 Modulates Angiogenic Activities of Human Endothelial Colony-Forming Cells Through IGF-1 Mechanism and Is a Marker of Senescence
CONCLUSIONS: Panx1 expression is upregulated in human ECFCs/EPCs with replication-induced senescence and during aging. Angiogenic potential of senescent ECFCs is improved by Panx1 reduction through increased IGF-1 production via activation of the FAK-ERK axis following calcium influx reduction. Our findings provide new strategies to evaluate EPC activities and rejuvenate senescent EPCs for therapeutic angiogenesis.PMID:37589139 | DOI:10.1161/ATVBAHA.123.319529
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 17, 2023 Category: Cardiology Authors: Ting-Yi Tien Yih-Jer Wu Cheng-Huang Su Chin-Ling Hsieh Bo-Jeng Wang Yi-Nan Lee Yeu Su Hung-I Yeh Source Type: research
Meta-Analysis of Single-Cell RNA-Seq Data Reveals the Mechanism of Formation and Heterogeneity of Tertiary Lymphoid Organ in Vascular Disease
CONCLUSIONS: Our analysis showed the existence of TLOs across 5 models of vascular diseases. The mechanisms that support TLOs formation in different models are heterogeneous. This study could be a valuable resource for understanding and discovering new therapeutic targets for various forms of vascular disease.PMID:37589134 | DOI:10.1161/ATVBAHA.123.318762
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 17, 2023 Category: Cardiology Authors: Xuejing Sun Yao Lu Junru Wu Qing Wen Zhengxin Li Yan Tang Yunmin Shi Tian He Lun Liu Wei Huang Chunyan Weng Qing Wu Qingzhong Xiao Hong Yuan Qingbo Xu Jingjing Cai Source Type: research
Pannexin 1 Modulates Angiogenic Activities of Human Endothelial Colony-Forming Cells Through IGF-1 Mechanism and Is a Marker of Senescence
CONCLUSIONS: Panx1 expression is upregulated in human ECFCs/EPCs with replication-induced senescence and during aging. Angiogenic potential of senescent ECFCs is improved by Panx1 reduction through increased IGF-1 production via activation of the FAK-ERK axis following calcium influx reduction. Our findings provide new strategies to evaluate EPC activities and rejuvenate senescent EPCs for therapeutic angiogenesis.PMID:37589139 | DOI:10.1161/ATVBAHA.123.319529
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 17, 2023 Category: Cardiology Authors: Ting-Yi Tien Yih-Jer Wu Cheng-Huang Su Chin-Ling Hsieh Bo-Jeng Wang Yi-Nan Lee Yeu Su Hung-I Yeh Source Type: research
Meta-Analysis of Single-Cell RNA-Seq Data Reveals the Mechanism of Formation and Heterogeneity of Tertiary Lymphoid Organ in Vascular Disease
CONCLUSIONS: Our analysis showed the existence of TLOs across 5 models of vascular diseases. The mechanisms that support TLOs formation in different models are heterogeneous. This study could be a valuable resource for understanding and discovering new therapeutic targets for various forms of vascular disease.PMID:37589134 | DOI:10.1161/ATVBAHA.123.318762
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 17, 2023 Category: Cardiology Authors: Xuejing Sun Yao Lu Junru Wu Qing Wen Zhengxin Li Yan Tang Yunmin Shi Tian He Lun Liu Wei Huang Chunyan Weng Qing Wu Qingzhong Xiao Hong Yuan Qingbo Xu Jingjing Cai Source Type: research
Pannexin 1 Modulates Angiogenic Activities of Human Endothelial Colony-Forming Cells Through IGF-1 Mechanism and Is a Marker of Senescence
CONCLUSIONS: Panx1 expression is upregulated in human ECFCs/EPCs with replication-induced senescence and during aging. Angiogenic potential of senescent ECFCs is improved by Panx1 reduction through increased IGF-1 production via activation of the FAK-ERK axis following calcium influx reduction. Our findings provide new strategies to evaluate EPC activities and rejuvenate senescent EPCs for therapeutic angiogenesis.PMID:37589139 | DOI:10.1161/ATVBAHA.123.319529
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 17, 2023 Category: Cardiology Authors: Ting-Yi Tien Yih-Jer Wu Cheng-Huang Su Chin-Ling Hsieh Bo-Jeng Wang Yi-Nan Lee Yeu Su Hung-I Yeh Source Type: research
Meta-Analysis of Single-Cell RNA-Seq Data Reveals the Mechanism of Formation and Heterogeneity of Tertiary Lymphoid Organ in Vascular Disease
CONCLUSIONS: Our analysis showed the existence of TLOs across 5 models of vascular diseases. The mechanisms that support TLOs formation in different models are heterogeneous. This study could be a valuable resource for understanding and discovering new therapeutic targets for various forms of vascular disease.PMID:37589134 | DOI:10.1161/ATVBAHA.123.318762
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 17, 2023 Category: Cardiology Authors: Xuejing Sun Yao Lu Junru Wu Qing Wen Zhengxin Li Yan Tang Yunmin Shi Tian He Lun Liu Wei Huang Chunyan Weng Qing Wu Qingzhong Xiao Hong Yuan Qingbo Xu Jingjing Cai Source Type: research
Pannexin 1 Modulates Angiogenic Activities of Human Endothelial Colony-Forming Cells Through IGF-1 Mechanism and Is a Marker of Senescence
CONCLUSIONS: Panx1 expression is upregulated in human ECFCs/EPCs with replication-induced senescence and during aging. Angiogenic potential of senescent ECFCs is improved by Panx1 reduction through increased IGF-1 production via activation of the FAK-ERK axis following calcium influx reduction. Our findings provide new strategies to evaluate EPC activities and rejuvenate senescent EPCs for therapeutic angiogenesis.PMID:37589139 | DOI:10.1161/ATVBAHA.123.319529
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 17, 2023 Category: Cardiology Authors: Ting-Yi Tien Yih-Jer Wu Cheng-Huang Su Chin-Ling Hsieh Bo-Jeng Wang Yi-Nan Lee Yeu Su Hung-I Yeh Source Type: research
Meta-Analysis of Single-Cell RNA-Seq Data Reveals the Mechanism of Formation and Heterogeneity of Tertiary Lymphoid Organ in Vascular Disease
CONCLUSIONS: Our analysis showed the existence of TLOs across 5 models of vascular diseases. The mechanisms that support TLOs formation in different models are heterogeneous. This study could be a valuable resource for understanding and discovering new therapeutic targets for various forms of vascular disease.PMID:37589134 | DOI:10.1161/ATVBAHA.123.318762
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 17, 2023 Category: Cardiology Authors: Xuejing Sun Yao Lu Junru Wu Qing Wen Zhengxin Li Yan Tang Yunmin Shi Tian He Lun Liu Wei Huang Chunyan Weng Qing Wu Qingzhong Xiao Hong Yuan Qingbo Xu Jingjing Cai Source Type: research
Pannexin 1 Modulates Angiogenic Activities of Human Endothelial Colony-Forming Cells Through IGF-1 Mechanism and Is a Marker of Senescence
CONCLUSIONS: Panx1 expression is upregulated in human ECFCs/EPCs with replication-induced senescence and during aging. Angiogenic potential of senescent ECFCs is improved by Panx1 reduction through increased IGF-1 production via activation of the FAK-ERK axis following calcium influx reduction. Our findings provide new strategies to evaluate EPC activities and rejuvenate senescent EPCs for therapeutic angiogenesis.PMID:37589139 | DOI:10.1161/ATVBAHA.123.319529
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 17, 2023 Category: Cardiology Authors: Ting-Yi Tien Yih-Jer Wu Cheng-Huang Su Chin-Ling Hsieh Bo-Jeng Wang Yi-Nan Lee Yeu Su Hung-I Yeh Source Type: research
Meta-Analysis of Single-Cell RNA-Seq Data Reveals the Mechanism of Formation and Heterogeneity of Tertiary Lymphoid Organ in Vascular Disease
CONCLUSIONS: Our analysis showed the existence of TLOs across 5 models of vascular diseases. The mechanisms that support TLOs formation in different models are heterogeneous. This study could be a valuable resource for understanding and discovering new therapeutic targets for various forms of vascular disease.PMID:37589134 | DOI:10.1161/ATVBAHA.123.318762
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 17, 2023 Category: Cardiology Authors: Xuejing Sun Yao Lu Junru Wu Qing Wen Zhengxin Li Yan Tang Yunmin Shi Tian He Lun Liu Wei Huang Chunyan Weng Qing Wu Qingzhong Xiao Hong Yuan Qingbo Xu Jingjing Cai Source Type: research
Pannexin 1 Modulates Angiogenic Activities of Human Endothelial Colony-Forming Cells Through IGF-1 Mechanism and Is a Marker of Senescence
CONCLUSIONS: Panx1 expression is upregulated in human ECFCs/EPCs with replication-induced senescence and during aging. Angiogenic potential of senescent ECFCs is improved by Panx1 reduction through increased IGF-1 production via activation of the FAK-ERK axis following calcium influx reduction. Our findings provide new strategies to evaluate EPC activities and rejuvenate senescent EPCs for therapeutic angiogenesis.PMID:37589139 | DOI:10.1161/ATVBAHA.123.319529
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 17, 2023 Category: Cardiology Authors: Ting-Yi Tien Yih-Jer Wu Cheng-Huang Su Chin-Ling Hsieh Bo-Jeng Wang Yi-Nan Lee Yeu Su Hung-I Yeh Source Type: research
Meta-Analysis of Single-Cell RNA-Seq Data Reveals the Mechanism of Formation and Heterogeneity of Tertiary Lymphoid Organ in Vascular Disease
CONCLUSIONS: Our analysis showed the existence of TLOs across 5 models of vascular diseases. The mechanisms that support TLOs formation in different models are heterogeneous. This study could be a valuable resource for understanding and discovering new therapeutic targets for various forms of vascular disease.PMID:37589134 | DOI:10.1161/ATVBAHA.123.318762
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 17, 2023 Category: Cardiology Authors: Xuejing Sun Yao Lu Junru Wu Qing Wen Zhengxin Li Yan Tang Yunmin Shi Tian He Lun Liu Wei Huang Chunyan Weng Qing Wu Qingzhong Xiao Hong Yuan Qingbo Xu Jingjing Cai Source Type: research
GAL3 Mediates Vascular Dysfunction in Obesity by Regulating NOX1
CONCLUSIONS: Deletion of GAL3 normalizes microvascular endothelial function in obese db/db mice, likely through an NOX1-mediated mechanism. Pathological levels of GAL3, and in turn NOX1, are amenable to improvements in metabolic status, presenting a potential therapeutic target to ameliorate pathological cardiovascular consequences of obesity.PMID:37586054 | DOI:10.1161/ATVBAHA.123.319476
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 16, 2023 Category: Cardiology Authors: Caleb A Padgett R óbert K Bátori Andrew C Speese Cody L Rosewater Weston B Bush Cassandra C Derella Stephen B Haigh Hunter G Sellers Zachary L Corley Madison A West James D Mintz Brittany B Ange Ryan A Harris Michael W Brands David J R Fulton David W St Source Type: research
Naringin binds to protein disulfide isomerase to inhibit its activity and modulate the blood coagulation rates: Implications in controlling thrombosis
Int J Biol Macromol. 2023 Aug 9:126241. doi: 10.1016/j.ijbiomac.2023.126241. Online ahead of print.ABSTRACTCurrently used antithrombotic drugs are beset with several drawbacks which necessitates the need for new and cheaper alternatives. Protein disulfide isomerase (PDI) is secreted in the blood plasma in cellular stress conditions and initiates the thrombus formation. A screening of library of natural compounds revealed that naringin had a high binding affinity for the PDI (-8.2 kcal/mol). Recombinant PDI was purified using the affinity chromatography. Incubation of purified PDI (3 μM) with naringin (0-100 μM, pH 7.4, 2...
Source: International Journal of Biological Macromolecules - August 11, 2023 Category: Biochemistry Authors: Abdul Burhan Khan Urfi Siddiqui Sana Fatima Ahmed Abdur Rehman Mohamad Aman Jairajpuri Source Type: research
