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Condition: Stroke
Management: National Institutes of Health (NIH)
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Total 1650 results found since Jan 2013.
Evaluation of stroke prognostication using age and NIH Stroke Scale index (SPAN-100 index) in delayed intravenous thrombolysis patients (beyond 4.5 hours)
the efficacy of delayed intravenous tissue plasminogen activator (tPA), beyond the 4.5 h window, is evolving. Advanced age and high admission National Institutes of Health Stroke Scale (NIHSS) score are proposed to adversely affect the outcome of delayed thrombolysis and limit the inclusion criteria. The summation of patient age and admission NIHSS score was introduced as the SPAN-100 index as a tool of prediction of the clinical outcome after acute ischemic stroke (AIS). We aimed to assess the SPAN-100 index in AIS thrombolysed patients after 4.5 h.
Source: Journal of Stroke and Cerebrovascular Diseases - February 16, 2022 Category: Neurology Authors: Nada Elsaid, Guido Bigliardi, Maria Luisa Dell'Acqua, Laura Vandelli, Ludovico Ciolli, Livio Picchetto, Giuseppe Borz ì, Riccardo Ricceri, Roberta Pentore, Stefano Vallone, Stefano Meletti, Ahmed Saied Source Type: research
Intravenous thrombolysis for mild stroke: NIHSS 3 –5 Versus NIHSS 0–2
Studies have shown that mild stroke patients with National Institutes of Health Stroke Scale (NIHSS) score 3 –5 but not 0–2 may benefit from the intravenous thrombolysis when compared with antiplatelet therapy. We aimed to compare the safety and effectiveness of thrombolysis in mild stroke with NIHSS score of 0–2 vs. 3–5 and identify the predictors of an excellent functional outcome in a real world longitudinal registry.
Source: Journal of Stroke and Cerebrovascular Diseases - March 10, 2023 Category: Neurology Authors: Liyuan Wang, Guangshuo Li, Yahui Hao, Manjun Hao, Yunyun Xiong Source Type: research
Association between clinician reported outcome and patient reported outcome measures one year after stroke
In evaluating the burden of stroke and the effect of stroke treatment, several clinicians ’ outcome measures regarding physical functioning are used, such as National Institutes of Health Stroke Scale (NIHSS),1 Barthel index,2 and modified Rankin Scale (mRS).3
Source: Journal of Stroke and Cerebrovascular Diseases - May 11, 2023 Category: Neurology Authors: Astrid Glimmerveen, Suzanne Holewijn, Sarah Vermeer Source Type: research
REVASCAT: a randomized trial of revascularization with SOLITAIRE FR® device vs. best medical therapy in the treatment of acute stroke due to anterior circulation large vessel occlusion presenting within eight‐hours of symptom onset
REVASCAT is a prospective, multicenter, randomized trial seeking to establish whether subjects meeting following main inclusion criteria: age 18‐80, baseline National Institutes of Health Stroke Scale ≥6, evidence of intracranial internal carotid artery or proximal (M1 segment) middle cerebral artery occlusion, Alberta Stroke Program Early Computed Tomography score of >7 on non‐contrast CT or >6 on diffusion‐weighted magnetic resonance imaging , ineligible for or with persistent occlusion after intravenous alteplase and procedure start within 8 hours from symptom onset, have higher rates of favorable outcome ...
Source: International Journal of Stroke - November 10, 2013 Category: Neurology Authors: Carlos A. Molina, Angel Chamorro, Àlex Rovira, Angeles Miquel, Joaquin Serena, Luis San Roman, Tudor G. Jovin, Antoni Davalos, Erik Cobo Tags: Protocols Source Type: research
Predictors of In-hospital Mortality and the Risk of Symptomatic Intracerebral Hemorrhage after Thrombolytic Therapy with Recombinant Tissue Plasminogen Activator in Acute Ischemic Stroke
This study aimed to determine the independent predictors of in-hospital mortality (IHM) and the risk of sICH after rt-PA therapy. A total of 1007 patients (mean age, 72 ± 12 years; 52% women; mean National Institutes of Health Stroke Scale [NIHSS] score, 11.6 ± 5.6) with AIS treated with rt-PA were enrolled in this study during a 42-month period beginning in November 2007. Univariate and multivariate regression analyses were performed to estimate the predictors of IHM. Eighty-three of the 1007 patients (8.2%) died during hospitalization (mean duration of hospitalization, 10 ± 1.8 days). Logistic regression estimated the...
Source: Journal of Stroke and Cerebrovascular Diseases - May 14, 2012 Category: Neurology Authors: Mohamed Al-Khaled, Christine Matthis, Jürgen Eggers Tags: Original Articles Source Type: research
Anemia on Admission Increases the Risk of Mortality at 6 Months and 1 Year in Hemorrhagic Stroke Patients in China
Background: The relationship between anemia and intracerebral hemorrhage is not clear. We investigated the associations between anemia at the onset and mortality or dependency in patients with intracerebral hemorrhage (ICH) registered at the China National Stroke Registry (CNSR).Methods: The CNSR recruited consecutive patients with diagnoses of ICH in 2007-2008. Their vascular risk factors, clinical presentations, and outcomes were recorded. The mortality and dependency at 1, 3, and 6 months and at 1 year were compared between ICH patients with and without anemia. A favorable outcome was defined as a modified Rankin Scal...
Source: Journal of Stroke and Cerebrovascular Diseases - March 17, 2014 Category: Neurology Authors: Yi-Jun Zeng, Gai-Fen Liu, Li-Ping Liu, Chun-Xue Wang, Xing-Quan Zhao, Yong-Jun Wang Tags: Original Articles Source Type: research
Intravenous Thrombolysis with Recombinant Tissue Plasminogen Activator in a Stroke Patient Treated with Rivaroxaban
As limited amounts of data are available regarding thrombolytic therapy for patients taking novel oral anticoagulants, thrombolytic therapy is not recommended in such cases. Here, we report an acute stroke patient taking rivaroxaban who received intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA). An 80-year-old man with a history of nonvalvular atrial fibrillation, who had been receiving 10 mg of rivaroxaban showed abrupt onset of aphasia and right hemiparesis. National Institutes of Health Stroke Scale score was 10.
Source: Journal of Stroke and Cerebrovascular Diseases - September 30, 2014 Category: Neurology Authors: Hideyuki Ishihara, Hiroaki Torii, Hirochika Imoto, Fumiaki Oka, Hirokazu Sadahiro, Michiyasu Suzuki Tags: Case Report Source Type: research
Circulating CD133+ CD34+ Progenitor Cells and Plasma Stromal-Derived Factor-1Alpha: Predictive Role in Ischemic Stroke Patients
In this study, we recruited 95 acute IS patients, 40 at-risk subjects, and 30 normal subjects. The National Institutes of Health Stroke Scale (NIHSS), infarct volume, and carotid intima-media thickness (IMT) were determined at day 1 and the modified Rankin scale (mRS) of functional outcome was assessed at day 21.
Source: Journal of Stroke and Cerebrovascular Diseases - November 22, 2014 Category: Neurology Authors: Yusen Chen, Bing Lu, Jinju Wang, Shuzhen Chen, Zhijun Lin, Xiaotang Ma, Yajing Liu, Bin Zhao, Yanfang Chen Source Type: research
New members selected for National Advisory Neurological Disorders and Stroke Council
Five prominent individuals from the neuroscience community have joined the National Advisory Neurological Disorders and Stroke Council, the principal advisory body to the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health.
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - January 29, 2015 Category: Neurology Source Type: news
Large-Vessel Occlusion Stroke: Effect of Recanalization on Outcome Depends on the National Institutes of Health Stroke Scale Score
Arterial recanalization is currently considered the main standard of successful early management of acute ischemic stroke. Intravenous (IV) thrombolysis with tissue plasminogen activator (tPa) is the only Food and Drug Administration–approved medical treatment. Large-vessel occlusion, estimated to account for up to 40% of all acute ischemic strokes, is often refractory to IV thrombolysis and is associated with a poor patient outcome. Mechanical recanalization procedures are therefore increasingly used in the treatment of large-vessel occlusion refractory to, or presenting outside the accepted time window for, IV thrombolysis.
Source: Journal of Stroke and Cerebrovascular Diseases - April 23, 2015 Category: Neurology Authors: Karolina Skagen, Mona Skjelland, David Russell, Eva A. Jacobsen Source Type: research
New members selected for National Advisory Neurological Disorders and Stroke Council
Six esteemed individuals have been selected to serve on the National Advisory Neurological Disorders and Stroke Council, the principal advisory body to the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health.
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - February 4, 2016 Category: Neurology Source Type: news
New imaging method may predict risk of post-treatment brain bleeding after stroke
In a study of stroke patients, investigators confirmed through MRI brain scans that there was an association between the extent of disruption to the brain’s protective blood-brain barrier and the severity of bleeding following invasive stroke therapy. The results of the National Institutes of Health-funded study were published in Neurology.
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - June 17, 2016 Category: Neurology Source Type: news
New members appointed to National Advisory Neurological Disorders and Stroke Council
Four distinguished individuals from the neuroscience community have been chosen to serve on the National Advisory Neurological Disorders and Stroke Council, the principal advisory body to the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health.
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - September 15, 2016 Category: Neurology Source Type: news
Fluid-Attenuated Inversion Recovery Vascular Hyperintensity Topography, Novel Imaging Marker for Revascularization in Middle Cerebral Artery Occlusion Clinical Sciences
In this study, we aimed to investigate the association between FVH topography or FVH-Alberta Stroke Program Early CT Score (ASPECTS) pattern and outcome in acute M1-middle cerebral artery occlusion patients with endovascular treatment.Methods—We included acute M1-middle cerebral artery occlusion patients treated with endovascular therapy (ET). All patients had diffusion-weighted imaging (DWI) and fluid-attenuated inversion recovery before ET. Distal FVH-ASPECTS was evaluated according to distal middle cerebral artery-ASPECT area (M1–M6) and acute DWI lesion was also reviewed. The presence of FVH inside and outside DWI-...
Source: Stroke - October 23, 2016 Category: Neurology Authors: Liu, D., Scalzo, F., Rao, N. M., Hinman, J. D., Kim, D., Ali, L. K., Saver, J. L., Sun, W., Dai, Q., Liu, X., Liebeskind, D. S. Tags: Magnetic Resonance Imaging (MRI), Revascularization, Ischemic Stroke Original Contributions Source Type: research
Validation of the National Institutes of Health Stroke Scale-8 to Detect Large Vessel Occlusion in Ischemic Stroke
Patients with acute ischemic stroke and large vessel occlusion (LVO) may benefit from prehospital identification and transfer to a center offering endovascular therapy.
Source: Journal of Stroke and Cerebrovascular Diseases - April 27, 2017 Category: Neurology Authors: Jelle Demeestere, Carlos Garcia-Esperon, Longting Lin, Andrew Bivard, Timothy Ang, Nicolas R. Smoll, Ashley Garnett, Allan Loudfoot, Ferdi Miteff, Neil Spratt, Mark Parsons, Christopher Levi Source Type: research
