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Methylprednisolone in patients undergoing cardiopulmonary bypass (SIRS): a randomised, double-blind, placebo-controlled trial
This study is registered with ClinicalTrials.gov, number NCT00427388. Findings Patients were recruited between June 21, 2007, and Dec 19, 2013. Complete 30-day data was available for all 7507 patients randomly assigned to methylprednisolone (n=3755) and to placebo (n=3752). Methylprednisolone, compared with placebo, did not reduce the risk of death at 30 days (154 [4%] vs 177 [5%] patients; relative risk [RR] 0·87, 95% CI 0·70–1·07, p=0·19) or the risk of death or major morbidity (909 [24%] vs 885 [24%]; RR 1·03, 95% CI 0·95–1·11, p=0·52). The most common safety outcomes in the methylprednisolone and placebo g...
Source: The Lancet - September 26, 2015 Category: Journals (General) Source Type: research

Cerebral fungal infections as a cause of stroke in cardiac surgery patients: Be Cautious!!
Neurological dysfunction in the postoperative period following cardiac surgery is most commonly attributed to thromboembolism or an intracranial bleed. Fungal infection is a rare cause of cerebral infarction and hemiparesis in an otherwise healthy patient. Cerebral Aspergillus infections are common in immunocompromised patients and is not considered as the first-line differential diagnosis of cerebral infarcts in a cardiac surgery patient. The infection is usually a secondary from lung, paranasal sinuses, or heart and forms microthrombi in large or medium sized cerebral vessels.
Source: Journal of Cardiothoracic and Vascular Anesthesia - March 30, 2023 Category: Anesthesiology Authors: Avneet Singh, Arushi Goyal, Manpreet Singh, Sidharth Garg, Sandeep Moudgil, Vipin Gupta Tags: Letter to the Editor Source Type: research