Filtered By:
Specialty: Chemistry
Condition: Multidrug Resistance
This page shows you your search results in order of date.
Order by Relevance | Date
Total 810 results found since Jan 2013.
Platinum(II) boron-dipyrromethene complex for cellular imaging and mitochondria-targeted photodynamic therapy in red light
Chem Asian J. 2023 Sep 14:e202300667. doi: 10.1002/asia.202300667. Online ahead of print.ABSTRACTCisplatin-derived platinum(II) complexes [Pt(NH3)2(pacac)](NO3) (1, DPP-Pt) and [Pt(NH3)2(Acac-RB)](NO3) (2, Acacplatin-RB), where Hpacac is 1,3-diphenyl-1,3-propanedione and HAcac-RB is a red-light active distyryl-BODIPY-appended acetylacetone ligand, are prepared, characterized and their photodynamic therapy (PDT) activity studied (RB abbreviated for red-light BODIPY). Complex 2 displayed an intense absorption band at λ = 652 nm (ε = 7.6 × 104 M-1 cm-1) and 601 nm (ε = 3.1 × 104 M-1 cm-1 ) in 1:1 DMSO-DPBS (Dulbecco's Ph...
Source: Chemistry, an Asian Journal - September 14, 2023 Category: Chemistry Authors: Aarti Upadhyay Amrita Nepalia Arpan Bera Deepak Kumar Saini Akhil Chakravarty Source Type: research
Identification of unique indolylcyanoethylenyl sulfonylanilines as novel structural scaffolds of potential antibacterial agents
Eur J Med Chem. 2023 Aug 30;260:115773. doi: 10.1016/j.ejmech.2023.115773. Online ahead of print.ABSTRACTThe increasing incidence of antibiotic resistance has forced the development of unique antimicrobials with novel multitargeting mechanisms to combat infectious diseases caused by multidrug-resistant pathogens. Structurally unique indolylcyanoethylenyl sulfonylanilines (ISs) were exploited as novel promising antibacterial agents to confront stubborn drug resistance. Some prepared ISs possessed favorable bacteriostatic action towards the tested bacteria. Especially, hydroxyethyl IS 14a exerted 8-fold more potent inhibitor...
Source: European Journal of Medicinal Chemistry - September 5, 2023 Category: Chemistry Authors: Xue-Mei Zhou Qian-Yue Li Xing Lu Rammohan R Yadav Bheemanaboina Bo Fang Gui-Xin Cai Cheng-He Zhou Source Type: research
Phospholipid headgroup composition modulates the molecular interactions and antimicrobial effects of sulfobetaine zwitterionic detergents against the "ESKAPE" pathogen < em > Pseudomonas aeruginosa < /em >
Chem Commun (Camb). 2023 Aug 29;59(70):10504-10507. doi: 10.1039/d3cc02320f.ABSTRACTWe determine the efficacy for three known structurally related, membrane active detergents against multidrug resistant and wild type strains of Pseudomonas aeruginosa. Accessible solution state NMR experiments are used to quantify phospholipid headgroup composition of the microbial membranes and to gain molecular level insight into antimicrobial mode of action.PMID:37644759 | DOI:10.1039/d3cc02320f
Source: Chemical Communications - August 30, 2023 Category: Chemistry Authors: Kira L F Hilton Howard Tolley Jose L Ortega-Roldan Gary S Thompson J Mark Sutton Charlotte K Hind Jennifer R Hiscock Source Type: research
Design of phenothiazine-based cationic amphiphilic derivatives incorporating arginine residues: Potential membrane-active broad-spectrum antimicrobials combating pathogenic bacteria in vitro and in vivo
In this study, the synthesis and biological evaluation of cationic amphiphilic phenothiazine-based derivatives were reported. Among them, the most promising compound 30 bearing a n-heptyl group and two arginine residues displayed potent bactericidal activity against both Gram-positive (MICs = 1.56 μg/mL) and Gram-negative bacteria (MICs = 3.125-6.25 μg/mL). Compound 30 showed low hemolysis activity (HC50 = 281.4 ± 1.6 μg/mL) and low cytotoxicity (CC50 ＞ 50 μg/mL) toward mammalian cells, as well as excellent salt resistance. Compound 30 rapidly killed bacteria by acting on the bacterial cell membrane and appeared les...
Source: European Journal of Medicinal Chemistry - August 29, 2023 Category: Chemistry Authors: Qian Yu Qiongna Cai Wanxin Liang Kewen Zhong Jiayong Liu Haizhou Li Yongzhi Chen Hongxia Li Shanfang Fang Rongcui Zhong Shouping Liu Shuimu Lin Source Type: research
Gallium reactivates 1st and 2nd generation quinolone antibiotics towards drug-resistantKlebsiella pneumoniae
Chem. Commun., 2023, Accepted Manuscript DOI: 10.1039/D3CC02916F, CommunicationTania Sultana, Rebekah. N. Duffin, Victoria L Blair, Philip Craig Andrews Klebsiella pneumoniae (KP) belongs to theEnterobacteriaceaefamily which have been designated as critical pathogens by the World Health Organisation due to the extent to which the bacteria have become multidrug-resistant, particularly towards... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - August 23, 2023 Category: Chemistry Authors: Tania Sultana Source Type: research
Tetrazole and oxadiazole derivatives as bioisosteres of tariquidar and elacridar: New potent P-gp modulators acting as MDR reversers
Eur J Med Chem. 2023 Aug 9;259:115716. doi: 10.1016/j.ejmech.2023.115716. Online ahead of print.ABSTRACTNew 2,5- and 1,5-disubstituted tetrazoles, and 2,5-disubstituted-1,3,4-oxadiazoles were synthesized as tariquidar and elacridar derivatives and studied as multidrug resistance (MDR) reversers. Their behaviour on the three ABC transporters P-gp, MRP1 and BCRP was investigated. All compounds inhibited the P-gp transport activity in MDCK-MDR1 cells overexpressing P-gp, showing EC50 values even in the low nanomolar range (compounds 15, 22). Oxadiazole derivatives were able to increase the antiproliferative effect of doxorubi...
Source: European Journal of Medicinal Chemistry - August 13, 2023 Category: Chemistry Authors: Laura Braconi Silvia Dei Marialessandra Contino Chiara Riganti Gianluca Bartolucci Dina Manetti Maria Novella Romanelli Maria Grazia Perrone Nicola Antonio Colabufo Stefano Guglielmo Elisabetta Teodori Source Type: research
De novo designed self-assembling helicomimetic lipooligoureas with antibacterial activity
Eur J Med Chem. 2023 Aug 2;259:115700. doi: 10.1016/j.ejmech.2023.115700. Online ahead of print.ABSTRACTThe overuse of antibiotics has led to a rise in infections caused by multidrug-resistant bacteria, resulting in a need for new antibacterial compounds with different modes of action. In this paper, we describe a new class of compounds called lipooligoureas, which are foldamer-based mimetics of antimicrobial lipopeptides. The lipooligoureas consist of an acyl chain connected to the N-terminus of an oligourea head group that exhibits a well-defined 2.5-helix secondary structure, which is further stabilized by the attachmen...
Source: European Journal of Medicinal Chemistry - August 5, 2023 Category: Chemistry Authors: Paulina Bachurska-Szpala Kinga Burdach Robert Lasek Dagmara Tymecka Joanna Juhaniewicz-D ębińska Dariusz Bartosik Karolina Pu łka-Ziach S ławomir Sęk Source Type: research
Current development of 1,2,3-triazole derived potential antimalarial scaffolds: Structure- activity relationship (SAR) and bioactive compounds
Eur J Med Chem. 2023 Jul 30;259:115699. doi: 10.1016/j.ejmech.2023.115699. Online ahead of print.ABSTRACTMalaria is among one of the most devastating and deadliest parasitic disease in the world claiming millions of lives every year around the globe. It is a mosquito-borne infectious disease caused by various species of the parasitic protozoan of the genus Plasmodium. The indiscriminate exploitation of the clinically used antimalarial drugs led to the development of various drug-resistant and multidrug-resistant strains of plasmodium which severely reduces the therapeutic effectiveness of most frontline medicines. Therefor...
Source: European Journal of Medicinal Chemistry - August 5, 2023 Category: Chemistry Authors: S Maheen Abdul Rahman Jasvinder Singh Bhatti Suresh Thareja Vikramdeep Monga Source Type: research
