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Efficient nanocarriers of siRNA therapeutics for cancer treatment.
Abstract Nanocarriers as drug delivery systems are promising and becoming popular, especially for cancer treatment. In addition to improving the pharmacokinetics of poorly soluble hydrophobic drugs by solubilizing them in a hydrophobic core, nanocarriers allow cancer-specific combination drug deliveries by inherent passive targeting phenomena and adoption of active targeting strategies. Nanoparticle-drug formulations can enhance the safety, pharmacokinetic profiles, and bioavailability of locally or systemically administered drugs, leading to improved therapeutic efficacy. Gene silencing by RNA interference (RNAi)...
Source: Translational Research : the journal of laboratory and clinical medicine - July 21, 2019 Category: Laboratory Medicine Authors: Subhan MA, Torchilin VP Tags: Transl Res Source Type: research

MRP1 knockdown down-regulates the deposition of collagen and leads to a reduced hypertrophic scar fibrosis
Abstract Multidrug resistance-associated protein 1 (MRP1) belongs to ATP-binding cassette transporters family. The overexpression of MRP1 is predominantly related with the failure of chemo-radiotherapy in various tumors. However, its possible role in hypertrophic scar (HS) is hardly investigated. Here we showed that the mRNA level and protein expression of MRP1 were higher in HS and HS derived fibroblasts (HSFs) than that in normal skin (NS) and NS derived fibroblasts (NSFs). Immunohistochemistry and immunofluorescence showed that the percentage of positive cells was higher in HS and HSFs. Meanwhile, the co-local...
Source: Journal of Molecular Histology - June 20, 2015 Category: Laboratory Medicine Source Type: research

UDP-Glucose Ceramide Glycosyltransferase Contributes to the Proliferation and Glycolysis of Cervical Cancer Cells by Regulating the PI3K/AKT Pathway
CONCLUSION: The knockdown of UGCG exerted an anti-tumor effect against cervical cancer through the inactivation of the PI3K/AKT pathway.PMID:34686508
Source: Annals of Clinical and Laboratory Science - October 23, 2021 Category: Laboratory Medicine Authors: Fenyun Zhang Hao Zhang Source Type: research

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