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Endocannabinoid receptors in the CNS: potential drug targets for the prevention and treatment of neurologic and psychiatric disorders.
Abstract The endocannabinoid system participates in the regulation of CNS homeostasis and functions, including neurotransmission, cell signaling, inflammation and oxidative stress, as well as neuronal and glial cell proliferation, differentiation, migration and survival. Endocannabinoids are produced by multiple cell types within the CNS and their main receptors, CB1 and CB2, are expressed in both neurons and glia. Signaling through these receptors is implicated in the modulation of neuronal and glial alterations in neuroinflammatory, neurodegenerative and psychiatric conditions, including Alzheimer's, Parkinson's...
Source: Current Neuropharmacology - February 16, 2020 Category: Drugs & Pharmacology Authors: Estrada JA, Contreras I Tags: Curr Neuropharmacol Source Type: research

"Understanding the Role of Hypoxia inducible factor during neurodegeneration for new therapeutics opportunities".
Abstract Neurodegeneration (NDG) is linked with the progressive loss of neural function with intellectual and/or motor impairment. Several diseases affecting older individuals, including Alzheimer's disease, Amyotrophic Lateral Sclerosis, Huntington's disease, Parkinson's disease, stroke, Multiple Sclerosis and many others, are the most relevant disorders associated with NDG. Since other pathologies such as refractory epilepsy, brain infections, or hereditary diseases such as "neurodegeneration with brain iron accumulation", also lead to chronic brain inflammation with loss of neural cells, NDG can be said to affe...
Source: Current Neuropharmacology - January 10, 2018 Category: Drugs & Pharmacology Authors: Merelli A, Rodriguez JCG, Folch J, Regueiro MR, Camins A, Alberto L Tags: Curr Neuropharmacol Source Type: research

Tetracyclines and neuromuscular disorders.
Abstract Tetracyclines are a class of antibiotics which could act as neuroprotective molecules in several neurological disorders, such as Huntington disease, Parkinson disease, stroke and multiple sclerosis. The main biological effects of tetracyclines are the inhibition of microglial activation, the attenuation of apoptosis and the suppression of reactive oxygen species production. The anti-apoptotic effect of tetracyclines involves the mitochondrion, and the major target for neuroprotective effects of tetracyclines lies within the complex network that links mitochondria, oxidative stress and apoptosis.Neuromuscu...
Source: Current Neuropharmacology - June 1, 2012 Category: Drugs & Pharmacology Authors: Orsucci D, Mancuso M, Filosto M, Siciliano G Tags: Curr Neuropharmacol Source Type: research

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