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Condition: Hole in the Heart
Education: Royal College of Surgeons
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Total 23 results found since Jan 2013.
Atrial Transcriptional Profiles of Molecular Targets Mediating Electrophysiological Function in Aging and Pgc-1 β Deficient Murine Hearts
Conclusion: These findings limit the possible roles of gene transcriptional changes in previously reported age-dependent pro-arrhythmic electrophysiologial changes observed in Pgc-1β-/- atria to an altered Ca2+-ATPase (Atp2a2) expression. This directly parallels previously reported arrhythmic mechanism associated with p21-activated kinase type 1 deficiency. This could add to contributions from the direct physiological outcomes of mitochondrial dysfunction, whether through reactive oxygen species (ROS) production or altered Ca2+ homeostasis.
Introduction
Atrial arrhythmias constitute a major public health pro...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research
Establishing minimally invasive cardiac surgery in a low-volume mitral surgery centre
DISCUSSION: It is possible for low-volume cardiac surgical centres to undertake minimally invasive surgical programmes with good outcomes and short learning curves. Despite technical complexities, with a team approach, the learning curve can be navigated safely.PMID:34058117 | DOI:10.1308/rcsann.2020.7092
Source: Annals of the Royal College of Surgeons of England - May 31, 2021 Category: Surgery Authors: B H Kirmani A Knowles P Saravanan J Zacharias Source Type: research
