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Patent Foramen Ovale-associated Stroke and COVID-19 Vaccination
Case –control studies have shown an association between patent foramen ovale (PFO) and cryptogenic stroke, which was observed particularly in patients younger than 55 years without conventional risk factors. The role of PFO closure in preventing stroke recurrence had been uncertain for many years, unt il four randomised clinical trials in 2017 and 2018 unequivocally demonstrated a benefit, with the number needed t...
Source: Radcliffe Cardiology - April 5, 2023 Category: Cardiology Authors: c242508f1d9059bc0f2aa9bdd5421ba2 Source Type: research

Unexplained arterial thrombosis: approach to diagnosis and treatment
We present a structured approach to diagnosis with consideration of common causes, including atherosclerosis and embolism, as well as uncommon causes, including medications and substances, vascular and anatomic abnormalities, systemic disorders, and thrombophilias. We highlight areas of management that have evolved within the past 5 years, including the use of dual-pathway inhibition in atherosclerotic disease, antithrombotic therapy selection in embolic stroke of undetermined source and left ventricular thrombus, the role of closure of patent foramen ovale for secondary stroke prevention, and the thrombotic potential of c...
Source: Atherosclerosis - December 10, 2021 Category: Cardiology Authors: Jori E May Stephan Moll Source Type: research