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Cardiovascular Biology of Prostanoids and Drug Discovery.
Abstract Prostanoids are a group of bioactive lipids that are synthesized de novo from membrane phospholipid-released arachidonic acid and have diverse functions in normal physiology and disease. NSAIDs, which are among the most commonly used medications, ameliorate pain, fever, and inflammation by inhibiting COX (cyclooxygenase), which is the rate-limiting enzyme in the biosynthetic cascade of prostanoids. The use of NSAIDs selective for COX-2 inhibition increases the risk of a thrombotic event (eg, myocardial infarction and stroke). All NSAIDs are associated with an increased risk of heart failure. Substantial v...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 15, 2020 Category: Cardiology Authors: Zhu L, Zhang Y, Guo Z, Wang M Tags: Arterioscler Thromb Vasc Biol Source Type: research

Vascular Regeneration in Peripheral Artery Disease.
Abstract Peripheral artery disease is a common disorder and a major cause of morbidity and mortality worldwide. Therapy is directed at reducing the risk of major adverse cardiovascular events and at ameliorating symptoms. Medical therapy is effective at reducing the incidence of myocardial infarction and stroke to which these patients are prone but is inadequate in relieving limb-related symptoms, such as intermittent claudication, rest pain, and ischemic ulceration. Limb-related morbidity is best addressed with surgical and endovascular interventions that restore perfusion. Current medical therapies have only mod...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 20, 2020 Category: Cardiology Authors: Cooke JP, Meng S Tags: Arterioscler Thromb Vasc Biol Source Type: research

Clonal Hematopoiesis of Indeterminate Potential Is Associated With Coronary Microvascular Dysfunction In Early Nonobstructive Coronary Artery Disease
CONCLUSIONS: In humans, we observe patients with CMD are more likely to have CHIP, and nearly one-third of major adverse cardiovascular events in CMD are mediated by CH.PMID:36951061 | DOI:10.1161/ATVBAHA.122.318928
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 23, 2023 Category: Cardiology Authors: Nadia Akhiyat Terra L Lasho Morsaleh Ganji Takumi Toya Chang-Xin Shi Xianfeng Chen Esteban Braggio Ali Ahmad Michel T Corban Keith Stewart Jenna Fernandez Zhuoer Xie Christy Finke Lilach O Lerman Mrinal M Patnaik Amir Lerman Source Type: research