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Drug: Polyethylene Glycol
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Total 30 results found since Jan 2013.
Highly Prolonged Release of the Cancer Vaccine and Immunomodulator via a Two-Layer Biodegradable Microneedle for Prophylactic Treatment of Metastatic Cancer
Biomacromolecules. 2023 Feb 21. doi: 10.1021/acs.biomac.2c01270. Online ahead of print.ABSTRACTSimultaneous sustained release of cancer vaccines and immunomodulators may effectively trigger durable immune responses and avoid multiple administrations. Here, we established a biodegradable microneedle (bMN) based on a biodegradable copolymer matrix made of polyethylene glycol (PEG) and poly(sulfamethazine ester urethane) (PSMEU). This bMN was applied to the skin and slowly degraded in the epidermis/dermis layers. Then, the complexes composed of a positively charged polymer (DA3), cancer DNA vaccine (pOVA), and toll-like recep...
Source: Biomacromolecules - February 21, 2023 Category: Biochemistry Authors: Huu Thuy Trang Duong Yue Yin Thai Minh Duy Le Ji Hoon Jeong Doo Sung Lee Source Type: research
NFK prevent postoperative abdominal adhesion through downregulating the TGF- β1 signaling pathway
CONCLUSIONS: Our findings support NFK as a potential anti-adhesive product that has the advantages of significant effectiveness, safety profile, and low cost, as well as clear mechanism of action.PMID:36331752 | DOI:10.1007/s11033-022-07795-2
Source: Molecular Biology Reports - November 4, 2022 Category: Molecular Biology Authors: Xin Zhao Xianmei Piao Bin Liu Rumeng Xie Tingting Zhan Min Liang Jiaying Tian Ruishuai Wang Chao Chen Jiuxin Zhu Yan Zhang Baofeng Yang Source Type: research
Top 20 Research Studies of 2021 for Primary Care Physicians
This article summarizes the top 20 research studies of 2021 identified as POEMs (patient-oriented evidence that matters) that did not address the COVID-19 pandemic. Sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists prevent adverse cardiovascular and renal outcomes in patients with type 2 diabetes mellitus and also reduce all-cause and cardiovascular mortality. Most older adults (mean age, 75 years) with prediabetes do not progress to diabetes. Among patients in this age group with type 2 diabetes treated with medication, an A1C level of less than 7% is associated with increased risk of...
Source: American Family Physician - July 15, 2022 Category: Primary Care Authors: Mark H Ebell Roland Grad Source Type: research
