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Alpha-gal syndrome: a review for the dermatologist.
Alpha-gal syndrome (AGS) is an allergy to “red” meat and other mammalian products due to immunoglobulin E (IgE) antibodies against the sugar moiety galactose-alpha-1,3-galactose (alpha-gal), which is acquired following tick bites. Clinically, AGS presents with urticaria, abdominal pain, nausea, and occasionally anaphylaxis, and has wide inter- and intra-personal variability. Because symptom onset is generally delayed by two to six hours after meat consumption, AGS can be easily confused with other causes of urticaria and anaphylaxis, such as chronic spontaneous urticaria (CSU) and mast cell activation syndrome (MCAS).
Source: Journal of the American Academy of Dermatology - May 5, 2023 Category: Dermatology Authors: Soumya Reddy, Lauren Yi, Bridget Shields, Thomas Platts-Mills, Jeffrey Wilson, R. Hal Flowers Source Type: research
Alpha-gal syndrome: A review for the dermatologist
Alpha-gal syndrome (AGS) is an allergy to “red meat” and other mammalian products due to immunoglobulin E (IgE) antibodies against the sugar moiety galactose-alpha-1,3-galactose (alpha-gal), which is acquired following tick bites. Clinically, AGS presents with urticaria, abdominal pain, nausea, and occasionally anaphylaxis, and has wide inter- and intra-personal variability. Because symptom onset is generally delayed by 2 to 6 hours after meat consumption, AGS can be easily confused with other causes of urticaria and anaphylaxis, such as chronic spontaneous urticaria (CSU) and mast cell activation syndrome (MCAS).
Source: Journal of the American Academy of Dermatology - May 5, 2023 Category: Dermatology Authors: Soumya Reddy, Lauren Yi, Bridget Shields, Thomas Platts-Mills, Jeffrey Wilson, R. Hal Flowers Tags: Clinical review Source Type: research
Ticks Carry More Diseases Than Just Lyme. Here ’ s What You Need to Know
Chris Rose lost ten years of his health—not to mention his gallbladder—to a single tick bite. The tick bit in 2010 and Rose, now a 50-year-old network engineer in Chapel Hill, N.C., thought little of it at the time.
“It was one of those lone star ticks,” he says, “and I just picked it off me. It wasn’t a big deal.”
Before long, however, Rose began developing crushing chest pains, abdominal discomfort, diarrhea, and other symptoms. Doctors screened him for heart disease, irritable bowel syndrome, and gallstones, and even removed his gallbladder to see if that might ease the intesti...
Source: TIME: Health - April 5, 2023 Category: Consumer Health News Authors: Jeffrey Kluger Tags: Uncategorized Disease healthscienceclimate Source Type: news
Tick Bites Can Trigger Meat Allergy: What You Need to Know
MONDAY, March 27, 2023 -- If you are experiencing mysterious recurrent vomiting, diarrhea and abdominal pain, you may want to consider that a tick could be responsible.
When the lone star tick bites a person, it can transmit something called...
Source: Drugs.com - Daily MedNews - March 27, 2023 Category: General Medicine Source Type: news
AGA Clinical Practice Update on Alpha-Gal Syndrome for the GI Clinician: Commentary
Alpha-gal syndrome causes an IgE-mediated reaction hours after eating beef, pork, other mammalian meat, or mammalian-derived products.1 Although the allergy was first described in patients with anaphylaxis and urticaria, gastrointestinal (GI) alpha-gal is a phenotype that increasingly is recognized and manifests with GI symptoms such as abdominal pain, diarrhea, nausea, and vomiting without predominant skin, respiratory, or circulatory symptoms.2 –9 It is important for gastroenterologists to be aware of this condition and to be capable of diagnosing and treating it in a timely manner.
Source: Clinical Gastroenterology and Hepatology - February 24, 2023 Category: Gastroenterology Authors: Sarah K. McGill, Jana G. Hashash, Thomas A. Platts-Mills Tags: Clinical Practice Update Source Type: research
Food Allergies and Alpha-gal Syndrome for the Gastroenterologist
AbstractPurpose of ReviewFood allergies are typically not considered as a cause of gastrointestinal (GI) distress without additional allergic symptoms, apart from celiac disease and eosinophilic esophagitis. However, recent reports of patients with alpha-gal syndrome who presented with GI-only symptoms like abdominal pain, vomiting, and diarrhea challenge this paradigm. Alpha-gal syndrome is an IgE-mediated allergy characterized by delayed reactions after eating mammalian meat or mammalian-derived products that contain galactose-alpha-1,3-galactose (alpha-gal). The purpose of this review is to discuss our current understan...
Source: Current Gastroenterology Reports - January 27, 2023 Category: Gastroenterology Source Type: research
We Used to Have a Lyme Disease Vaccine. Are We Ready to Bring One Back?
At my animal hospital in upstate New York, an epicenter of the U.S. tick epidemic, my dog Fawn lets out a whimper as the veterinarian injects her with her annual Lyme disease shot. I roll my eyes. She doesn’t know how good she has it.
The injection means that if a tick bites her (and in rural New York, a tick always does), the creepy crawly will feast on dog blood that’s been supercharged with a Lyme bacteria-killing substance, and Lyme disease won’t be transmitted to Fawn.
I wish I could be shot up with that superpower. Currently, there is no human vaccine for Lyme disease—even though more than two...
Source: TIME: Health - June 17, 2021 Category: Consumer Health News Authors: Mandy Oaklander Tags: Uncategorized Disease feature Source Type: news
Alpha-Gal Allergy as a Cause of Intestinal Symptoms in a Gastroenterology Community Practice
CONCLUSIONS: Clinicians practicing in the region of the Lone Star tick habitat need to be aware that patients with IgE to alpha-gal can manifest with isolated abdominal pain and diarrhea, and these patients respond well to dietary exclusion of mammalian products.PMID:33655311 | DOI:10.14423/SMJ.0000000000001223
Source: Southern Medical Journal - March 3, 2021 Category: General Medicine Authors: Nathan E Richards Robert D Richards Source Type: research
