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Could saccadic function be a useful marker of stroke recovery?
There is no pharmacological therapy presently available to improve the long-term recovery from acute ischaemic stroke. Either there hasn't yet been a suitable treatment trialled, or the tools for measuring recovery have not been sensitive enough. It is critical therefore to continue to search for robust objective markers of stroke recovery in parallel with the push for drug discovery. Can saccade measures provide such a marker? Dong et al report that in a limited number of mild stroke patients, saccadic parameters that probe cognitive function, especially errors of inhibition during antisaccade and memory-guided paradigms,...
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 15, 2013 Category: Neurosurgery Authors: Anderson, T. Tags: Other rehabilitative therapies, Genetics, Immunology (including allergy), Brain stem / cerebellum, Drugs: CNS (not psychiatric), Movement disorders (other than Parkinsons), Multiple sclerosis, Parkinson's disease, Spinal cord, Stroke, Ophthalmology, Memor Source Type: research

Measuring arm function early after stroke: is the DASH good enough?
Conclusions RMT methods identified limitations missed by CTT and indicate areas for improvement of the DASH as an upper limb measure for acute stroke. Findings, similar to those identified in multiple sclerosis, highlight the need for scales to have strong conceptual underpinnings, with their development and modification guided by sophisticated psychometric methods.
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 12, 2016 Category: Neurosurgery Authors: Baker, K., Barrett, L., Playford, E. D., Aspden, T., Riazi, A., Hobart, J. Tags: Immunology (including allergy), Multiple sclerosis, Stroke Cerebrovascular disease Source Type: research

Risk of stroke in multiple sclerosis and neuromyelitis optic spectrum disorder: a Nationwide cohort study in South Korea
Conclusions The risk of stroke is increased in patients with MS and NMOSD and seemed comparable between the two conditions. This is the first study that estimates the risk of stroke in patients with MS and NMOSD within the same population.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 14, 2022 Category: Neurosurgery Authors: Cho, E. B., Yeo, Y., Jung, J. H., Jeong, S.-M., Han, K.-d., Shin, D. W., Min, J.-H. Tags: Multiple sclerosis Source Type: research

E-248 Postpartum vertebral artery dissections: a report of 7 cases and literature review
ConclusionA limited cohort of 33 ppVADs exist in the literature. This study contributes 7 additional cases and suggests that, despite heterogenous management of ppVAD, the resulting outcomes were favorable.Disclosures V. Lazarov: None. A. Monteiro: None. F. Almayman: None. M. Waqas: None. J. Cappuzzo: None. E. Levy: None. A. Siddiqui: None.
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Lazarov, V., Monteiro, A., Almayman, F., Waqas, M., Cappuzzo, J., Levy, E., Siddiqui, A. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

New therapeutic option for drop foot with the ActiGait peroneal nerve stimulator – A technical note
Publication date: Available online 9 July 2015 Source:World Neurosurgery Author(s): K. Daniel Martin , Witold Polanski , Gabriele Schackert , Stephan B. Sobottka A drop foot occurs in up to 20% of stroke patients and leads to an increased risk of falls. Until recently, only a foot orthosis or surface stimulation were able to improve the gait of these patients. Recent studies have shown that direct peroneal nerve stimulation with an implantable four-channel peroneal nerve stimulator (ActiGait) allows independent electrode adjustment and leads to better functional results and an improved quality of life. The application of...
Source: World Neurosurgery - July 10, 2015 Category: Neurosurgery Source Type: research

E-086 non-ischemic etiologies by ct perfusion
ConclusionThe radiologist should be aware of the imaging findings of etiologies which may mimic an acute ischemic stroke on CT perfusion imaging.DisclosuresM. Chehab: None. J. Wilseck: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2015 Category: Neurosurgery Authors: Chehab, M., Wilseck, J. Tags: SNIS 12th Annual Meeting Electronic Poster Abstracts Source Type: research

Idiopathic hypertrophic cranial pachymeningitis: a rare but treatable cause of headache and facial pain
Introduction Idiopathic Hypertrophic Cranial Pachymeningitis (IHCP) is a rare disease with pain and compression related cranial nerve dysfunction as main clinical features. The leading diagnostic finding of IHCP consists of diffuse or localised thickening of the dura, which demands appropriate imaging and image interpretation. This case description aims at increasing the awareness for the clinical symptoms and imaging findings of this rare disease to allow prompt diagnosis and treatment initiation. Case description An 82-year-old man presented with recurrent left sided headache and worsening facial pain, which had begun mo...
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 15, 2013 Category: Neurosurgery Authors: Khalil, M., Ebner, F., Fazekas, F., Enzinger, C. Tags: Immunology (including allergy), Meningitis, Brain stem / cerebellum, Cranial nerves, Headache (including migraine), Infection (neurology), Multiple sclerosis, Pain (neurology), Stroke, Hypertension, Ophthalmology, Radiology, Surgical diagnostic tests, Ear Source Type: research

Trigeminal neuralgia after pontine infarction affecting the ipsilateral trigeminal nerve
A 57-year-old man presented with numbness, paraesthesia and lancinating pain on the left side of the face, which had developed suddenly 10 days previously. He had hypertension and no history of headache. His facial pain was characterised by a brief electric shock-like pain, which was evoked by light stimuli, and also occurred spontaneously. A neurological examination showed a mild decrease in sensation on the left side of the face, mainly with V2 and V3 distribution, and on the left oral cavity, including the tongue and buccal mucosa. Other neurological examinations were normal, including the corneal reflex and the mo...
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 8, 2013 Category: Neurosurgery Authors: Kim, J. B., Yu, S. Tags: Immunology (including allergy), Brain stem / cerebellum, Cranial nerves, Headache (including migraine), Multiple sclerosis, Neuroimaging, Neuromuscular disease, Pain (neurology), Peripheral nerve disease, Stroke, Hypertension, Ophthalmology, Drugs: psychi Source Type: research

Sunshine and multiple sclerosis
In 1960, Donald Acheson1 made the seminal observation that the global distribution of multiple sclerosis (MS) may be related to available hours of sunshine; this observation was met with disbelief at the time. However, over the subsequent more than 50 years, it has become clear that he may well be right. The effect of sunlight exposure and subsequent vitamin D production (generated by photolysis of 7-dehydrocholesterol in the skin by ultraviolet radiation (UVR)) on the onset and progression of MS has become a significant research focus particularly over the last 10 years, with large-scale clinical trials of vitam...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 2, 2013 Category: Neurosurgery Authors: Taylor, B. V. Tags: Immunology (including allergy), Multiple sclerosis, Stroke Editorial commentaries Source Type: research

Think outside the box, collapse the box, and take a sharp knife to it!
A 74 year–old woman presented in December 2011 with left sided cerebellar symptoms. She was initially diagnosed as having a posterior circulation infarction and discharged from hospital on appropriate medication. However, over the following month she continued to deteriorate, developing increasing unsteadiness, falls, nausea and vomiting. Following a second admission in January 2012 she had a single seizure and developed focal left sided myoclonus affecting mainly the upper limb. Over the following month the myoclonus spread to affect all four limbs, although it remained more prominent on the left side. There was evi...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Dobson, R., McMillan, A., Kung, K., Thom, M., Davis, A., Simister, R., Giovannoni, G., Gnanapavan, S. Tags: Immunology (including allergy), HIV/AIDS, Tropical medicine (infectious diseases), Brain stem / cerebellum, Epilepsy and seizures, Infection (neurology), Multiple sclerosis, Stroke, Ophthalmology, Radiology, Surgical diagnostic tests Association of Brit Source Type: research

Cannabinoid use in progressive inflammatory brain disease (cupid) mri sub-study
Conclusion 9–THC was not better than placebo at reducing the rates of new T1 or T2 lesions or brain atrophy in patients with progressive MS.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Mallik, S., Ball, S., Dalton, C., MacManus, D., Tozer, D., Miller, D., Zajicek, J. Tags: Immunology (including allergy), Drugs: CNS (not psychiatric), Multiple sclerosis, Stroke, Radiology, Drugs: musculoskeletal and joint diseases, Radiology (diagnostics) Association of British Neurologists (ABN) joint meeting with the Royal College of Phy Source Type: research

Electrolyte imbalance triggering relapse of inflammatory neuropathy
We describe a case of a 71 year old female with a fourteen year history of chronic inflammatory demyelinating polyneuropathy (CIDP) and stable monoclonal gammopathy, normally maintained on three–weekly intravenous immunoglobulin (IVIG) therapy. At her best baseline, she has a normal motor examination and reduced vibration sense only to the ankles. She presented with a four week history of progressive numbness and paresthesiae in all four limbs, reduced balance, a decline in mobility with frequent falls and reduced hand function. The deterioration developed after a week of non–bloody diarrhoea with night sweats ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Keshavan, A., Gandhi, S., Lunn, M., Reilly, M. Tags: Neurogastroenterology, Immunology (including allergy), Drugs: CNS (not psychiatric), Multiple sclerosis, Neuromuscular disease, Peripheral nerve disease, Stroke, Hypertension Association of British Neurologists (ABN) joint meeting with the Royal College Source Type: research

Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study
Conclusions Autologous MSCs can be safely administered in secondary progressive MS with evidence to suggest structural, functional and physiological improvement following treatment consistent with neuroprotection. The transient treatment response seen implied a likely requirement for repeat infusions to sustain benefit in the long–term.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Connick, P., Chandran, S. Tags: Immunology (including allergy), Multiple sclerosis, Stroke, Ophthalmology Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Sodium accumulation is associated with disability and progression in multiple sclerosis: a 23na mri study
Conclusions Significant increases in sodium were seen in lesions and normal appearing brain tissues in MS. Increased concentration of sodium in lesions, cortical grey matter, NAWM and basal ganglia in SPMS versus RRMS indicates greater neuroaxonal metabolic dysfunction and/or loss in the former group. MRI measurement of sodium concentration in vivo is likely to reflect clinically relevant neuroaxonal pathophysiology and may be a useful outcome measure in trials of putative neuroprotective treatments.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Paling, D., Solanky, B., Riemer, F., Tozer, D., Wheeler-Kingshott, C., Kapoor, R., Golay, X., Miller, D. Tags: Immunology (including allergy), Multiple sclerosis, Stroke, Radiology, Radiology (diagnostics) Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Selective dorsal rhizotomy for spasticity not associated with cerebral palsy: reconsideration of surgical inclusion criteria.
Abstract Children with spastic diplegia from cerebral palsy (CP) experience measurable improvement in their spasticity and motor function following selective dorsal rhizotomy (SDR). The role of this operation in the treatment of other spasticity causes is less well defined. A literature review was undertaken to survey outcomes from SDRs performed outside the CP population. Multiple sclerosis was the most common diagnosis found, accounting for 74 of 145 patients described. Selective dorsal rhizotomies have also been reported in patients with traumatic brain and spinal cord injuries, ischemic and hemorrhagic stroke,...
Source: Neurosurgical Focus - November 1, 2013 Category: Neurosurgery Authors: Gump WC, Mutchnick IS, Moriarty TM Tags: Neurosurg Focus Source Type: research

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