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Revised cardiac score index is a predictor of long-term outcomes after carotid endarterectomy
Conclusion: RCRI and CtRCRI did not predict MACE in the perioperative period but are good predictors of 30-day complications (Clavien-Dindo ≥2). Both RCRI and CtRCRI have good prognostic value as predictors of long-term cardiovascular events.PMID:35171024 | DOI:10.1024/0301-1526/a000988
Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases - February 16, 2022 Category: Surgery Authors: Filipa J ácome Leandro N óbrega Ant ónio Pereira-Neves Lu ís Duarte-Gamas Joana Mour ão Pedro Videira-Reis Marina Dias-Neto Jo ão Rocha-Neves Source Type: research

Impaired Activity of Ryanodine Receptors Contributes to Calcium Mishandling in Cardiomyocytes of Metabolic Syndrome Rats
Conclusion Principal findings of this work are that abnormal Ca2+ transient amplitude, contractile dysfunction; and impaired relaxation of MetS cardiomyocytes underlies intrinsic dysfunctional RyR2 and SERCA pump. Abnormal activity of RyRs was evidenced by its decreased ability to bind [3H]-ryanodine. Although the MetS condition does not modify RyR2 protein expression, its phosphorylation at Ser2814 is decreased, which impairs its capacity for activation during ECC. The dysfunctional RyRs, together with a decreased activity of SERCA pump due to decreased Thr17-PLN phosphorylation suggest a downregulation of CaMKII in MetS...
Source: Frontiers in Physiology - April 29, 2019 Category: Physiology Source Type: research