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Angiotensin-Converting Enzyme and Hypertension: A Systemic Analysis of Various ACE Inhibitors, Their Side Effects, and Bioactive Peptides as a Putative Therapy for Hypertension
J Renin Angiotensin Aldosterone Syst. 2023 Jun 21;2023:7890188. doi: 10.1155/2023/7890188. eCollection 2023.ABSTRACTHypertension is a major risk factor for heart attack, produce atherosclerosis (hardening of the arteries), congestive heart failure, stroke, kidney infection, blindness, end-stage renal infection, and cardiovascular diseases. Many mechanisms are involved in causing hypertension, i.e., via calcium channels, alpha and beta receptors, and the renin-angiotensin system (RAS). RAS has an important role in blood pressure control and is also involved in the metabolism of glucose, homeostasis, and balance of electroly...
Source: Atherosclerosis - June 30, 2023 Category: Cardiology Authors: Hafiz Ahmad Huma Khan Shabirul Haque Shameem Ahmad Namita Srivastava Azhar Khan Source Type: research

Mechanism of Hypoxia-Mediated Smooth Muscle Cell Proliferation Leading to Vascular Remodeling
Biomed Res Int. 2022 Dec 24;2022:3959845. doi: 10.1155/2022/3959845. eCollection 2022.ABSTRACTVascular remodeling refers to changes in the size, contraction, distribution, and flow rate of blood vessels and even changes in vascular function. Vascular remodeling can cause cardiovascular and cerebrovascular diseases. It can also lead to other systemic diseases, such as pulmonary hypertension, pulmonary atherosclerosis, chronic obstructive pulmonary disease, stroke, and ascites of broilers. Hypoxia is one of the main causes of vascular remodeling. Prolonged hypoxia or intermittent hypoxia can lead to loss of lung ventilation,...
Source: Atherosclerosis - January 3, 2023 Category: Cardiology Authors: Xiaojuan Huang Elif Ece Akg ün Khalid Mehmood Hui Zhang Zhaoxin Tang Ying Li Source Type: research

Predictive values of coronary artery calcium and arterial stiffness for long-term cardiovascular events in patients with stable coronary artery disease
CONCLUSIONS: A CAC score ≥100 or a CAVI ≥ 9.0 predicts the long-term occurrence of MACEs in both asymptomatic and symptomatic patients with stable CAD. These two noninvasive tests can be used as screening tools to guide treatment for the prevention of future CV events.PMID:36448219 | DOI:10.1002/clc.23955
Source: Atherosclerosis - November 30, 2022 Category: Cardiology Authors: Thosaphol Limpijankit Sutipong Jongjirasiri Krissada Meemook Nattawut Unwanatham Ammarin Thakkinstian Jiraporn Laothamatas Source Type: research

Molecular explanation of Wnt/ βcatenin antagonist pyrvinium mediated calcium equilibrium changes in aging cardiovascular disorders
Mol Biol Rep. 2022 Sep 15. doi: 10.1007/s11033-022-07863-7. Online ahead of print.ABSTRACTThe symptoms of ageing are somewhat different and can lead to the altered role of the cardiovascular system at the levels of genetic, biochemical, tissue, organ, and systems. Ageing is an autonomous cardiovascular risk factor. In the ageing rat heart, oxidative and inflammatory stress, immune cell infiltration, increasing myeloperoxidase function, elevated caspase-3 activity, and protein fibronectins were detected and associated with ageing and cardiovascular disease. The intracellular Ca2 + homeostasis disturbed in an older heart dra...
Source: Atherosclerosis - September 15, 2022 Category: Cardiology Authors: Khalid Saad Alharbi Yogendra Singh Obaid Afzal Abdulmalik Saleh Alfawaz Altamimi Imran Kazmi Fahad A Al-Abbasi Sami I Alzarea Dinesh Kumar Chellappan Sachin Kumar Singh Kamal Dua Gaurav Gupta Source Type: research

The complex genetic basis of fibromuscular dysplasia, a systemic arteriopathy associated with multiple forms of cardiovascular disease
Clin Sci (Lond). 2022 Aug 31;136(16):1241-1255. doi: 10.1042/CS20210990.ABSTRACTArtery stenosis is a common cause of hypertension and stroke and can be due to atherosclerosis accumulation in the majority of cases and in a small fraction of patients to arterial fibromuscular dysplasia (FMD). Artery stenosis due to atherosclerosis is widely studied with known risk factors (e.g. increasing age, male gender, and dyslipidemia) to influence its etiology, including genetic factors. However, the causes of noninflammatory and nonatherosclerotic stenosis in FMD are less understood. FMD occurs predominantly in early middle-age women,...
Source: Atherosclerosis - August 31, 2022 Category: Cardiology Authors: Adrien Georges Nabila Bouatia-Naji Source Type: research

Increased ionized calcium-magnesium-ratio in elderly hypertensives - relationship to artheriosclerosis
CONCLUSIONS: As described earlier, a magnesium deficiency can be involved in the pathogenesis of hypertension and in elderly.The increased calcium-magnesium-ratio is also a pathogenetic factor for artheriosclerosis often found in elderly hypertensives with vascular damage, e.g. stroke, renal insufficiency or heart disease.PMID:36026911 | DOI:10.1097/01.hjh.0000836640.98666.86
Source: Atherosclerosis - August 26, 2022 Category: Cardiology Authors: Kisters Kisters Klaus Kisters Lukas Gremmler Bernhard Sprenger Jutta Gr öber Uwe Source Type: research

Increased ionized calcium-magnesium-ratio in elderly hypertensives - relationship to artheriosclerosis
CONCLUSIONS: As described earlier, a magnesium deficiency can be involved in the pathogenesis of hypertension and in elderly.The increased calcium-magnesium-ratio is also a pathogenetic factor for artheriosclerosis often found in elderly hypertensives with vascular damage, e.g. stroke, renal insufficiency or heart disease.PMID:36026911 | DOI:10.1097/01.hjh.0000836640.98666.86
Source: Atherosclerosis - August 26, 2022 Category: Cardiology Authors: Kisters Kisters Klaus Kisters Lukas Gremmler Bernhard Sprenger Jutta Gr öber Uwe Source Type: research

Nomogram Including Serum Ion Concentrations to Screen for New-Onset Hypertension in Rural Chinese Populations Over a Short-Term Follow-up
CONCLUSIONS: The newly developed nomogram has good predictive ability and may effectively assess hypertension risk in high-risk rural areas in China.PMID:35569931 | DOI:10.1253/circj.CJ-22-0016
Source: Circulation Journal - May 15, 2022 Category: Cardiology Authors: Xueyao Zhang Guangxiao Li Yingxian Sun Source Type: research

Hypertension Management in Primary Care in the Capital Area of Iceland
CONCLUSION: As has recently been shown in epidemiologic studies hypertension in Iceland is both underdiagnosed and undertreated although the country ranks high on both counts in international comparison. Furthermore, the fact that under half of hypertensive patients in general practice in the capital area reach the targeted treatment goals, cannot be considered an acceptable. Thus, it is of immense importance to improve both the diagnosis and the treatment of HT.PMID:35103619 | DOI:10.17992/lbl.2022.02.675
Source: Atherosclerosis - February 1, 2022 Category: Cardiology Authors: Stefan Julius Adalsteinsson Jon Steinar Jonsson Hannes Hrafnkelsson Gudmundur Thorgeirsson Emil Larus Sigurdsson Source Type: research

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