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Nephrolithiasis predicts ischemic stroke: A longitudinal follow-up study using a national sample cohort.
This study sought to evaluate associations between nephrolithiasis and hemorrhagic and ischemic stroke using a national sample cohort from Korea. Data from 2002 to 2013 were collected for individuals ≥ 20 years of age in the Korean National Health Insurance Service (NHIS)-National Sample Cohort. We extracted nephrolithiasis patients (n = 22,636) and 1:4 matched controls (n = 90,544) and analyzed the occurrence of stroke. Matching was performed based on age, sex, income, region of residence, hypertension, diabetes mellitus, and dyslipidemia history. Crude and adjusted hazard ratios (HRs) were calculated using Cox proporti...
Source: International Journal of Medical Sciences - September 17, 2019 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

< em > HTRA1 < /em > Variants and the Interaction with Smoking Confer the Genetic Susceptibility to Ischemic Stroke
This study aimed at evaluating the association of HTRA1 with IS and four tagging single-nucleotide polymorphisms (SNPs) were genotyped in a cohort of 4,098 Chinese. The mRNA level of HTRA1 in 72 IS cases and 72 hypertension controls were measured and compared. In whole population, SNP rs2268350 (C>T) was significantly associated with IS incidence (P=0.034). Stratification analysis observed significant association of rs2268350 in male, smoking and drinking populations, rs2672587 (C>G) in smoking and nonsmoking populations and rs3793917 (C>G) in smoking, nonsmoking and nondrinking populations with stroke respectivel...
Source: International Journal of Medical Sciences - March 22, 2021 Category: Biomedical Science Authors: Yuanrui Tian Wuzhuang Tang Song Yang Yanping Zhao Yanchun Chen Xianghai Zhao Chunlan Liu Xiaotian Chen Chong Shen Source Type: research

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