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Specialty: Cytology
Condition: Translocation
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Total 921 results found since Jan 2013.
Piperacetazine directly binds to the PAX3::FOXO1 fusion protein and inhibits its transcriptional activity
Cancer Res Commun. 2023 Sep 21. doi: 10.1158/2767-9764.CRC-23-0119. Online ahead of print.ABSTRACTThe tumor-specific chromosomal translocation product, PAX3::FOXO1, is an aberrant fusion protein that plays a key role for oncogenesis in the alveolar subtype of rhabdomyosarcoma (RMS). PAX3::FOXO1 represents a validated molecular target for alveolar RMS and successful inhibition of its oncogenic activity is likely to have significant clinical applications. Even though several PAX3::FOXO1 function-based screening studies have been successfully completed, a directly binding small molecule inhibitor of PAX3::FOXO1 has not been r...
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Kay Nakazawa Taryn Shaw Young K Song Marilyn Kouassi-Brou Anna Molotkova Purushottam B Tiwari Hsien-Chao Chou Xinyu Wen Jun S Wei Emre Deniz Jeffrey Toretsky Charles Keller Frederic G Barr Javed Khan Aykut Üren Source Type: research
Fatty acid oxidation mediated by malonyl-CoA decarboxylase represses renal cell carcinoma progression
Cancer Res. 2023 Sep 20. doi: 10.1158/0008-5472.CAN-23-0969. Online ahead of print.ABSTRACTFatty acid metabolism reprogramming is a prominent feature of clear cell renal cell carcinoma (ccRCC). Increased lipid storage supports ccRCC progression, highlighting the importance of understanding the molecular mechanisms driving altered fatty acid synthesis in tumors. Here, we identified that malonyl-CoA decarboxylase (MLYCD), a key regulator of fatty acid anabolism, was downregulated in ccRCC, and low expression correlated with poor prognosis in patients. Restoring MLYCD expression in ccRCC cells decreased the content of malonyl...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Lijie Zhou Yongbo Luo Yuenan Liu Youmiao Zeng Junwei Tong Mengting Li Yaxin Hou Kaixuan Du Yabin Qi Wenbang Pan Yuanhao Liu Rongli Wang Fengyan Tian Chaohui Gu Ke Chen Source Type: research
Plant-derived cell-penetrating microprotein α-astratide aM1 targets Akt signaling and alleviates insulin resistance
Cell Mol Life Sci. 2023 Sep 16;80(10):293. doi: 10.1007/s00018-023-04937-y.ABSTRACTInsulin-resistant diabetes is a common metabolic disease with serious complications. Treatments directly addressing the underlying molecular mechanisms involving insulin resistance would be desirable. Our laboratory recently identified a proteolytic-resistant cystine-dense microprotein from huáng qí (Astragalus membranaceus) called α-astratide aM1, which shares high sequence homology to leginsulins. Here we show that aM1 is a cell-penetrating insulin mimetic, enters cells by endocytosis, and activates the PI3K/Akt signaling pathway indepe...
Source: Cellular and Molecular Life Sciences : CMLS - September 16, 2023 Category: Cytology Authors: Bamaprasad Dutta Shining Loo Antony Kam James P Tam Source Type: research
Reciprocal negative feedback regulation of ATF6 α and PTEN promotes prostate cancer progression
Cell Mol Life Sci. 2023 Sep 16;80(10):292. doi: 10.1007/s00018-023-04940-3.ABSTRACTPhosphatase and tensin homolog (PTEN) loss tightly correlates with prostate cancer (PCa) progression and metastasis. Inactivation of PTEN leads to abnormal activation of PI3K/AKT pathway. However, results from clinical trials with AKT inhibitors in PCa have been largely disappointing. Identification of novel regulators of PTEN in PTEN-dysfunctional PCa is urgently needed. Here we demonstrated that the expression level of PTEN is inversely correlated with the signature score of unfolded protein response (UPR) in PCa. Importantly, PTEN suppres...
Source: Cellular and Molecular Life Sciences : CMLS - September 16, 2023 Category: Cytology Authors: Tingting Feng Ru Zhao Hanwen Zhang Feifei Sun Jing Hu Meng Wang Mei Qi Ling Liu Lin Gao Yabo Xiao Junhui Zhen Weiwen Chen Lin Wang Bo Han Source Type: research
Plant-derived cell-penetrating microprotein α-astratide aM1 targets Akt signaling and alleviates insulin resistance
Cell Mol Life Sci. 2023 Sep 16;80(10):293. doi: 10.1007/s00018-023-04937-y.ABSTRACTInsulin-resistant diabetes is a common metabolic disease with serious complications. Treatments directly addressing the underlying molecular mechanisms involving insulin resistance would be desirable. Our laboratory recently identified a proteolytic-resistant cystine-dense microprotein from huáng qí (Astragalus membranaceus) called α-astratide aM1, which shares high sequence homology to leginsulins. Here we show that aM1 is a cell-penetrating insulin mimetic, enters cells by endocytosis, and activates the PI3K/Akt signaling pathway indepe...
Source: Cellular and Molecular Life Sciences : CMLS - September 16, 2023 Category: Cytology Authors: Bamaprasad Dutta Shining Loo Antony Kam James P Tam Source Type: research
Reciprocal negative feedback regulation of ATF6 α and PTEN promotes prostate cancer progression
Cell Mol Life Sci. 2023 Sep 16;80(10):292. doi: 10.1007/s00018-023-04940-3.ABSTRACTPhosphatase and tensin homolog (PTEN) loss tightly correlates with prostate cancer (PCa) progression and metastasis. Inactivation of PTEN leads to abnormal activation of PI3K/AKT pathway. However, results from clinical trials with AKT inhibitors in PCa have been largely disappointing. Identification of novel regulators of PTEN in PTEN-dysfunctional PCa is urgently needed. Here we demonstrated that the expression level of PTEN is inversely correlated with the signature score of unfolded protein response (UPR) in PCa. Importantly, PTEN suppres...
Source: Cellular and Molecular Life Sciences : CMLS - September 16, 2023 Category: Cytology Authors: Tingting Feng Ru Zhao Hanwen Zhang Feifei Sun Jing Hu Meng Wang Mei Qi Ling Liu Lin Gao Yabo Xiao Junhui Zhen Weiwen Chen Lin Wang Bo Han Source Type: research
Intratumoral Bacteria as Mediators of Cancer Immunotherapy Response
Cancer Res. 2023 Sep 15;83(18):2985-2986. doi: 10.1158/0008-5472.CAN-23-1857.ABSTRACTMultiple lines of evidence spanning from animal models to human clinical trials indicate that the microbiome influences cancer immunotherapy response. Whereas initial studies focused exclusively on the gastrointestinal (gut) microbiota-tumor axis, more recent studies have examined the possibility that bacteria located within tumor cells or within the tumor microenvironment mediate cancer treatment response. Strikingly, this phenomenon has been demonstrated in cancers that arise in anatomic locations that are traditionally thought to be dev...
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Karen S Sfanos Source Type: research
An improved Erk biosensor detects oscillatory Erk dynamics driven by mitotic erasure during early development
Dev Cell. 2023 Sep 9:S1534-5807(23)00436-7. doi: 10.1016/j.devcel.2023.08.021. Online ahead of print.ABSTRACTExtracellular signal-regulated kinase (Erk) signaling dynamics elicit distinct cellular responses in a variety of contexts. The early zebrafish embryo is an ideal model to explore the role of Erk signaling dynamics in vivo, as a gradient of activated diphosphorylated Erk (P-Erk) is induced by fibroblast growth factor (Fgf) signaling at the blastula margin. Here, we describe an improved Erk-specific biosensor, which we term modified Erk kinase translocation reporter (modErk-KTR). We demonstrate the utility of this bi...
Source: Developmental Cell - September 15, 2023 Category: Cytology Authors: Scott G Wilcockson Luca Guglielmi Pablo Araguas Rodriguez Marc Amoyel Caroline S Hill Source Type: research
RhoB promotes Salmonella survival by regulating autophagy
Eur J Cell Biol. 2023 Aug 30;102(4):151358. doi: 10.1016/j.ejcb.2023.151358. Online ahead of print.ABSTRACTSalmonella enterica serovar Typhimurium manipulates cellular Rho GTPases for host cell invasion by effector protein translocation via the Type III Secretion System (T3SS). The two Guanine nucleotide exchange (GEF) mimicking factors SopE and -E2 and the inositol phosphate phosphatase (PiPase) SopB activate the Rho GTPases Rac1, Cdc42 and RhoA, thereby mediating bacterial invasion. S. Typhimurium lacking these three effector proteins are largely invasion-defective. Type III secretion is crucial for both early and later ...
Source: European Journal of Cell Biology - September 13, 2023 Category: Cytology Authors: Marco Kirchenwitz Jessica Halfen Kristin von Peinen Silvia Prettin Jana Kollasser Susanne Zur Lage Wulf Blankenfeldt Cord Brakebusch Klemens Rottner Anika Steffen Theresia E B Stradal Source Type: research
