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Development of Shigella conjugate vaccines targeting Shigella flexneri 2a and S. flexneri 3a using a simple platform-approach conjugation by squaric acid chemistry
Vaccine. 2023 Jul 1:S0264-410X(23)00738-7. doi: 10.1016/j.vaccine.2023.06.052. Online ahead of print.ABSTRACTThere is a need for vaccines effective against shigella infection in young children in resource-limited areas. Protective immunity against shigella infection targets the O-specific polysaccharide (OSP) component of lipopolysaccharide. Inducing immune responses to polysaccharides in young children can be problematic, but high level and durable responses can be induced by presenting polysaccharides conjugated to carrier proteins. An effective shigella vaccine will need to be multivalent, targeting the most common glob...
Source: Vaccine - July 3, 2023 Category: Allergy & Immunology Authors: Meagan Kelly Anjali Mandlik Richelle C Charles Smriti Verma Stephen B Calderwood Daniel T Leung Rajib Biswas Kamrul Islam Mohammad Kamruzzaman Fahima Chowdhury Farhana Khanam Willie F Vann Ashraful Islam Khan Taufiqur Rahman Bhuiyan Firdausi Qadri Anthony Source Type: research

Development of a multiplex-based immunoassay for the characterization of diphtheria, tetanus and acellular pertussis antigens in human combined DTaP vaccines
J Immunol Methods. 2023 Apr 24:113483. doi: 10.1016/j.jim.2023.113483. Online ahead of print.ABSTRACTRoutine batch quality testing before vaccine release, notably for potency evaluation, still relies on animal use for several animal and human vaccines. In this context, the VAC2VAC project is a public-private consortium of 22 partners funded by EU whose the main objective is to reduce the number of animal used for batch testing by developing immunoassays that could be implemented for routine potency assessment of vaccines. This paper focused on the development of a Luminex-based multiplex assay to monitor the consistency of...
Source: Journal of Immunological Methods - April 26, 2023 Category: Allergy & Immunology Authors: Vermeulen Maxime Feck Isabelle Francotte Antoine Laura Hassall Tesolin Lorenzo Van Molle Wim Pizzato Romain Laurent Thierry Hoebreck Charline Stickings Paul Dobly Alexandre Source Type: research

The Pasteurian contribution to the history of vaccines
C R Biol. 2022 Sep 13;345(3):93-107. doi: 10.5802/crbiol.83.ABSTRACTVaccination, the transmission of "vaccine", a benign disease of cows, to immunize human beings against smallpox, was invented by Jenner at the end of the eighteenth century. Pasteur, convinced that the vaccine microbe was an attenuated form of the smallpox microbe, showed that, similarly, attenuated forms of other microbes immunized against animal diseases. When applying this principle to rabies, he realized that, in this case, the vaccine was in fact composed of dead microbes. One of his students immediately exploited this result to devise a vaccine again...
Source: Comptes Rendus Biologies - February 28, 2023 Category: Biology Authors: Maxime Schwartz Source Type: research

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