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Autophagy after subarachnoid hemorrhage: Can cell death be good?
Abstract Autophagy is a prosurvival, reparative process that maintains cellular homeostasis through lysosomal degradation of selected cytoplasmic components and programmed death of old, dysfunctional, or unnecessary cytoplasmic entities. According to growing evidence, autophagy shows beneficial effects following subarachnoid hemorrhage (SAH). SAH is considered one of the most devastating forms of stroke. Though autophagy is prosurvival and aids in repair, deregulated or excessive autophagy results in increased cell death, more brain injury, and worse outcome. The aim of this review lies in revealing the pathophysi...
Source: Current Neuropharmacology - November 23, 2017 Category: Drugs & Pharmacology Authors: Ho WM, Akyol O, Reis H, Reis C, McBride D, Thome C, Zhang J Tags: Curr Neuropharmacol Source Type: research