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Source: Journal of Stroke and Cerebrovascular Diseases
Condition: Subarachnoid Hemorrhage
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Total 235 results found since Jan 2013.
Intrathecal Treatment of Cerebral Vasospasm
Treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH) remains a major therapeutic challenge. Systemic drug administration is the current treatment of choice, but patients often do not respond beneficially to this approach. Intrathecal (IT) drug administration has several anatomic and pharmacodynamic advantages over conventional systemic treatment of cerebral vasospasm. We reviewed the most recent literature describing IT administration of several drugs to treat aneurysm-induced SAH and cerebral vasospasm, including 16 clinical trials using IT fibrinolytic agents and 10 trials using several IT vasod...
Source: Journal of Stroke and Cerebrovascular Diseases - June 1, 2012 Category: Neurology Authors: Yi Ping Zhang, Lisa B.E. Shields, Tom L. Yao, Shervin R. Dashti, Christopher B. Shields Tags: Review Articles Source Type: research
Antihypertensives Are Administered Selectively in Emergency Department Patients with Subarachnoid Hemorrhage
Elevated blood pressure is common in patients with acute subarachnoid hemorrhage (SAH). American Heart Association guidelines do not specify a blood pressure target, but limited data suggest that systolic blood pressure (SBP) ≥160 mmHg is associated with increased risk of rebleeding and neurologic decline. In a population-based study, we determined the frequency of antihypertensive therapy in emergency department (ED) patients with SAH and the proportion of those patients with SBP ≥160 mmHg who received this therapy. In 2005, nontraumatic SAH cases were retrospectively ascertained at 16 hospitals in our region by scree...
Source: Journal of Stroke and Cerebrovascular Diseases - April 12, 2012 Category: Neurology Authors: Virginia Culyer, Erin McDonough, Christopher J. Lindsell, Kathleen Alwell, Charles J. Moomaw, Brett M. Kissela, Matthew L. Flaherty, Pooja Khatri, Daniel Woo, Simona Ferioli, Joseph P. Broderick, Dawn Kleindorfer, Opeolu Adeoye Tags: Original Articles Source Type: research
Effects of the Experimental Subarachnoid Hemorrhage on the Eicosanoid Receptors in Nicotine-induced Contraction of the Rat Basilar Artery
Conclusions: BLT2 receptor seemed to be more involved in the nicotine-induced contraction than the BLT1 receptor. SAH did not affect the involvement of eicosanoids in the nicotine-induced contraction of the rat basilar artery. The present study shows the involvement of some of the arachidonic acid metabolites into signaling pathways of nicotine-induced contraction. It will serve to improve therapeutic interventions of SAH and suggests a promising approach to protect the cerebral vasculature of cigarette smokers.
Source: Journal of Stroke and Cerebrovascular Diseases - August 14, 2012 Category: Neurology Authors: Xu Ji, Cristina C. Trandafir, Aimin Wang, Kazuyoshi Kurahashi Tags: Original Articles Source Type: research
Predictors of Severity of Cerebral Vasospasm caused by Aneurysmal Subarachnoid Hemorrhage
Background: Cerebral vasospasm is one of the leading causes of poor outcome after aneurysmal subarachnoid hemorrhage. The risk factors for the development of vasospasm have been evaluated in many clinical studies. However, it remains unclear if vasospasm severity can be predicted. The purpose of this study was to determine if different demographic and clinical factors that appear to be predictors of vasospasm can also prognosticate the severity of cerebral vasospasm.Methods: We retrospectively analyzed consecutive patients with subarachnoid hemorrhage who underwent endovascular vasospasm treatment in a single center. In or...
Source: Journal of Stroke and Cerebrovascular Diseases - February 18, 2013 Category: Neurology Authors: Ramazan Jabbarli, Sven Gläsker, Johannes Weber, Christian Taschner, Manfred Olschewski, Vera Van Velthoven Tags: Original Articles Source Type: research
Nonaneurysmal Subarachnoid Hemorrhage after Udenafil Intake
We report a 67-year-old man who presented with severe headache after taking 50 mg of udenafil, a new phosphodiesterase 5 inhibitor. Computed tomographic imaging of the brain revealed a small amount of acute subarachnoid hemorrhage localized around basal cisterns (anterior to midbrain and pons). There were no aneurysms in the cerebral arteries, although vein of Galen stenosis was suspected after magnetic resonance venography. This case anecdotally suggests that phosphodiesterase 5 inhibition might trigger perimesencephalic subarachnoid hemorrhage with venous hypertension possibly associated with vein of Galen stenosis.
Source: Journal of Stroke and Cerebrovascular Diseases - May 6, 2013 Category: Neurology Authors: Eun-Kee Bae, Jong-Hyeon Ahn, Jeong-Jin Park Tags: Case Reports Source Type: research
Relative Changes in Transcranial Doppler Velocities Are Inferior to Absolute Thresholds in Prediction of Symptomatic Vasospasm after Subarachnoid Hemorrhage
The absolute transcranial Doppler (TCD) velocity threshold has been validated as a screening tool for vasospasm after subarchnoid hemorrhage (SAH). We assessed whether relative changes in velocity were superior to absolute TCD thresholds in the detection of symptomatic vasospasm. We reviewed consecutive patients with aneurysmal SAH who underwent serial TCD monitoring and survived at least 7 days. We recorded initial flow velocity (IFV) and maximal flow velocity (MFV) of the middle cerebral artery (MCA) serially up to 14 days from admission. We calculated relative flow velocity changes (MFV/IFV) and maximum change in mean ...
Source: Journal of Stroke and Cerebrovascular Diseases - September 10, 2012 Category: Neurology Authors: Konark Malhotra, James J. Conners, Vivien H. Lee, Shyam Prabhakaran Tags: Original Articles Source Type: research
Statin Use and Risk of Cerebral Aneurysm Rupture: A Hospital-based Case–control Study in Japan
Conclusions: This observation from a hospital-based case-control study in Japan suggested that there is inverse relationship between use of statins and cerebral aneurysm rupture. Future clinical studies are needed.
Source: Journal of Stroke and Cerebrovascular Diseases - May 21, 2013 Category: Neurology Authors: Yayoi Yoshimura, Yoshitaka Murakami, Makoto Saitoh, Toshihiro Yokoi, Tomohiro Aoki, Katsuyuki Miura, Hirotsugu Ueshima, Kazuhiko Nozaki, SSS Research Group Tags: Original Articles Source Type: research
Associations of Collagen Type I α2 Polymorphisms with the Presence of Intracranial Aneurysms in Patients from Germany
Conclusions: The COL1A2 gene is associated with intracranial aneurysms in a subset of the German population. However, it is not responsible for the majority of aneurysms, and further candidate genes need to be identified to develop sensitive genetic screening for patients at risk.
Source: Journal of Stroke and Cerebrovascular Diseases - June 24, 2013 Category: Neurology Authors: Sven Gläsker, Bawarjan Schatlo, Jan-Helge Klingler, Veit Braun, Peter Spangenberg, In-Se Kim, Vera van Velthoven, Josef Zentner, Hartmut P.H. Neumann Tags: Original Articles Source Type: research
A Ruptured Aneurysm Arising at the Leptomeningeal Collateral Circulation from the Extracranial Vertebral Artery to the Posterior Inferior Cerebellar Artery Associated with Bilateral Vertebral Artery Occlusion
We report an extremely rare case of a small ruptured aneurysm of the leptomeningeal collateral circulation from the vertebral artery (VA) to the posterior inferior cerebellar artery (PICA); this aneurysm was associated with bilateral VA occlusion. A 72-year-old woman with sudden headache, nausea, and subarachnoid hemorrhage (SAH) was admitted to our hospital. On admission, no evidence of cerebral signs or cranial nerve palsy was found. Computed tomography imaging showed SAH predominantly in the posterior fossa, and digital subtraction angiography revealed bilateral VA occlusion and the left VA aneurysm located proximal to ...
Source: Journal of Stroke and Cerebrovascular Diseases - December 9, 2013 Category: Neurology Authors: Masashi Chonan, Shinjitu Nishimura, Naoto Kimura, Masayuki Ezura, Hiroshi Uenohara, Teiji Tominaga Tags: Case Reports Source Type: research
Subarachnoid Hemorrhage after Resuscitation from Out-of-hospital Cardiac Arrest
This study was undertaken to retrospectively investigate clinical features of subarachnoid hemorrhage (SAH) with cardiopulmonary arrest in patients achieving return of spontaneous circulation (ROSC) in order to explore the possibility of long-term survival.Methods: Of 143 SAH patients with cardiopulmonary arrest in our hospital between April 2004 and June 2012, data on 59 (41%) patients who attained ROSC were analyzed to determine the predictive factors for neurologic recovery and outcome. Recovery of brainstem reflexes and improvement of Glasgow Coma Scale (GCS) motor score were noted (postresuscitation neurologic restora...
Source: Journal of Stroke and Cerebrovascular Diseases - May 15, 2013 Category: Neurology Authors: Kei Miyata, Takeshi Mikami, Yasufumi Asai, Satoshi Iihoshi, Nobuhiro Mikuni, Eichi Narimatsu Tags: Original Articles Source Type: research
Outcome of Cervicocranial Artery Dissection with Different Treatments: A Systematic Review and Meta-analysis
Conclusions: Endovascular treatment yields a better outcome, with greater benefit in patients with ruptured cervicocranial artery dissection, dissecting aneurysms, and a Hunt–Hess score of 3 or more. Randomized controlled trials comparing these 2 therapeutic strategies are needed.
Source: Journal of Stroke and Cerebrovascular Diseases - November 13, 2013 Category: Neurology Authors: Yan Chen, Jing-Jing Guan, Ai-Hua Liu, Hong Ding, Yuan Shao, Yun Xu Tags: Original Articles Source Type: research
The SAH Score: A Comprehensive Communication Tool
Background: The Hunt and Hess grade and World Federation of Neurological Surgeons (WFNS) scale are commonly used to predict mortality after aneurysmal subarachnoid hemorrhage (aSAH). Our objective was to improve the accuracy of mortality prediction compared with the aforementioned scales by creating the “SAH score.”Methods: The aSAH database at our institution was analyzed for factors affecting in-hospital mortality using multiple logistic regression analysis. Scores were weighted based on relative risk of mortality after stratification of each of these variables. Glasgow Coma Scale (GCS) was subdivided into groups of ...
Source: Journal of Stroke and Cerebrovascular Diseases - October 7, 2013 Category: Neurology Authors: Neeraj S. Naval, Robert G. Kowalski, Tiffany R. Chang, Filissa Caserta, J. Ricardo Carhuapoma, Rafael J. Tamargo Tags: Original Articles Source Type: research
Incidence, Epidemiology, and Treatment of Aneurysmal Subarachnoid Hemorrhage in 12 Midwest Communities
Only 8 studies have investigated the incidence and epidemiology of aneurysmal subarachnoid hemorrhage (aSAH) in the United States. This is the first investigation in Indiana, which has some of the highest rates of tobacco smoking and obesity in the nation. The authors prospectively identified 441 consecutive patients with aSAH from 2005 to 2010 at 2 hospitals where the majority of cases are treated. Incidence calculations were based on US Census populations. Epidemiologic variables included demography; risk factors; Hunt and Hess scale; Fisher grade; number, location, and size of aneurysms; treatment type; and complication...
Source: Journal of Stroke and Cerebrovascular Diseases - October 21, 2013 Category: Neurology Authors: Mary Ziemba-Davis, Bradley N. Bohnstedt, Troy D. Payner, Thomas J. Leipzig, Erin Palmer, Aaron A. Cohen-Gadol Tags: Original Articles Source Type: research
Ruptured Aneurysm of the PICA Communicating Artery: A Case Report
A 47-year-old man presented with a rare aneurysm arising from the posterior inferior cerebellar artery communicating artery (PICA com A), manifesting as subarachnoid with intraventricular hemorrhage. Cerebral angiography showed a defect of the left PICA, and the left PICA region was supplied by a communicating artery formed by the fusion of branches from the right PICA and right vertebral artery. Aneurysms arose in the communicating artery, and a small, unruptured fusiform aneurysm was observed adjacent to a ruptured aneurysm. Trapping was performed for the 2 aneurysms with occipital artery (OA)–PICA bypass. Six cases of...
Source: Journal of Stroke and Cerebrovascular Diseases - October 10, 2013 Category: Neurology Authors: Daisuke Haga, Takao Kuroki, Shunpei Andoh, Masaaki Nemoto, Nobuo Sugo, Takeki Nagao Tags: Case Reports Source Type: research
Rosuvastatin Ameliorates Early Brain Injury after Subarachnoid Hemorrhage via Suppression of Superoxide Formation and Nuclear Factor-Kappa B Activation in Rats
Conclusions: The present study demonstrates that rosuvastatin pretreatment ameliorates EBI after SAH through the attenuation of oxidative stress and NF-κB–mediated inflammation.
Source: Journal of Stroke and Cerebrovascular Diseases - February 14, 2014 Category: Neurology Authors: Ken Uekawa, Yu Hasegawa, Mingjie Ma, Takashi Nakagawa, Tetsuji Katayama, Daisuke Sueta, Kensuke Toyama, Keiichiro Kataoka, Nobutaka Koibuchi, Takayuki Kawano, Jun-ichi Kuratsu, Shokei Kim-Mitsuyama Tags: Original Articles Source Type: research
