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Phentermine associated recurrent intracerebral hemorrhage
Awareness of obesity as a risk factor for cardiovascular events has increased in recent years. Many medications have been developed to suppress appetite to achieve weight loss. Phentermine is one of many medications that often used for weight loss. However, the sympathomimetic effect of phentermine can result in palpitations, hypertension, and tachycardia [1]. Neurological complications include irritability, ischemic stroke, posterior reversible encephalopathy syndrome (PRES) and hemorrhagic stroke [2 –6].
Source: Journal of the Neurological Sciences - August 22, 2018 Category: Neurology Authors: Stephanie McNeill, Eyad Almallouhi, Forrest J. Lowe, Tanya N. Turan Tags: Letter to the Editor Source Type: research

Neurocognitive outcomes after aneurysmal subarachnoid hemorrhage: Identifying inflammatory biomarkers
Aneurysmal subarachnoid hemorrhage (aSAH) is a severe type of stroke which carries a high case-fatality rate. Those who survive the ictus of aneurysm rupture harbor substantial risks of neurological morbidity, functional disability, and cognitive dysfunction. Although the pervasiveness of cognitive impairment is widely acknowledged as a long-term sequela of aSAH, the mechanisms underlying its development are poorly understood. The onset of aSAH elicits activation of the inflammatory cascade, and ongoing neuroinflammation is suspected to contribute to secondary complications, such as vasospasm and delayed cerebral ischemia.
Source: Journal of the Neurological Sciences - June 25, 2018 Category: Neurology Authors: Eric Watson, Dale Ding, Nicolas K. Khattar, D. Erik Everhart, Robert F. James Tags: Review Article Source Type: research

Domain-specific characterisation of early cognitive impairment following spontaneous intracerebral haemorrhage
This study aims to describe the cognitive profile following acute ICH and explore how cerebral amyloid angiopathy (CAA) may impact performance. We retrospectively reviewed 187 consecutive patients with ICH (mean age 58.9  years, 55.6% male) with available imaging and neuropsychological data (median 12 days after stroke).
Source: Journal of the Neurological Sciences - May 21, 2018 Category: Neurology Authors: Gargi Banerjee, Mary Summers, Edgar Chan, Duncan Wilson, Andreas Charidimou, Lisa Cipolotti, David J. Werring Source Type: research

Idarucizumab-facilitated intravenous thrombolysis in acute stroke with dabigatran: Two cases with hemorrhagic transformation
Idarucizumab is a monoclonal antibody fragment specifically designed for counteracting the effect of a direct oral anti-coagulant (DOAC), namely dabigatran [1]. In a phase III clinical trial, idarucizumab is able to normalize the coagulation profiles in patients suffered from life-threatening bleeding or prepared for emergent intervention [2]. Idarucizumab-facilitated intravenous thrombolysis (IT) was thus considered as a reasonable therapeutic strategy for patients with acute ischemic stroke under dabigatran treatment [3].
Source: Journal of the Neurological Sciences - March 14, 2018 Category: Neurology Authors: Yi-Te Tsai, Yu-Jen Hsiao, Li-Kai Tsai, Pao-Sheng Yen, Fu-Yu Lin, Ching-Hua Lu, Chen-Wen Fang Tags: Letter to the Editor Source Type: research

MRI scout images can detect the acute intracerebral hemorrhage on CT
We examined whether MRI scout imaging can detect ICHs observed by computed tomography (CT).
Source: Journal of the Neurological Sciences - February 3, 2018 Category: Neurology Authors: Toshiyuki Hayashi, Junya Aoki, Kentaro Suzuki, Yuki Sakamoto, Satoshi Suda, Seiji Okubo, Masahiro Mishina, Kazumi Kimura Source Type: research

A nomogram to predict the probability of mortality after first-ever acute manifestations of cerebral small vessel disease
Symptomatic lacunar stroke (LS) and deep intracerebral hemorrhage (dICH) represent the acute manifestations of type 1 cerebral small vessel disease (cSVD). Recently, two studies showed that the risk factor profile of dICH differs from that associated with LS in subjects with biologically plausible cSVD; however, the prognostic predictors after acute manifestations are currently lacking.We aimed to develop a nomogram for individualized prediction of the mortality probability in a cohort of patients with a first-ever acute manifestation of biologically plausible cSVD.
Source: Journal of the Neurological Sciences - December 18, 2017 Category: Neurology Authors: Manuel Cappellari, Cecilia Zivelonghi, Gianni Turcato, Stefano Forlivesi, Nicola Micheletti, Giampaolo Tomelleri, Paolo Bovi, Bruno Bonetti Tags: Clinical Short Communication Source Type: research

Resumption of antiplatelet therapy in patients with primary intracranial haemorrhage: Balancing benefits and risks
Intracranial or intracerebral haemorrhage (ICH) can be primary ICH (in the absence of a single clear underlying lesion) and secondary ICH (as a complication of a pre-existing lesion, such as vascular malformation or tumour; or antithrombotic therapy). Primary ICH is the most common type of ICH, and overall, is the second most common subtype of stroke accounting for approximately 10 to 20% of all strokes.
Source: Journal of the Neurological Sciences - December 1, 2017 Category: Neurology Authors: Ahsan A. Khan, Gregory Y.H. Lip Tags: Editorial Source Type: research

Number of studies, heterogeneity, generalisability, and the choice of method for meta-analysis
We read the meta-analysis performed by Charidimou et al. [1] with a lot of interest and would like to congratulate the team for their attempt to consolidate the evidence on the risk of intracerebral hemorrhage in microbleed-positive ischemic stroke patients with atrial fibrillation. Amid the scarcity of published data on cerebral microbleeds (CMBs) in this specific ischemic stroke population, this systematic review holds unique importance.
Source: Journal of the Neurological Sciences - September 20, 2017 Category: Neurology Authors: Ambrish Singh, Salman Hussain, Abul Kalam Najmi Tags: Letter to the Editor Source Type: research

Meta-analysis methodology in the microbleeds field: The relevance of the clinical question and study quality in choosing the most appropriate model
We appreciate Singh et al. interest in our recent meta-analysis and decision schema for ischaemic stroke patients with atrial fibrillation in the presence of cerebral microbleeds [1], and thank them for the insightful comments. The overall aim of our paper was to summarise all available data from cohort studies on the topic, generate estimates from a preliminary aggregate-level meta-analysis on the association between cerebral microbleeds presence and risk of future intracererbral haemorrhage in this setting, and finally use these data to propose a practical decision algorithm in the field.
Source: Journal of the Neurological Sciences - September 18, 2017 Category: Neurology Authors: Andreas Charidimou, Gregoire Boulouis, Sara Shams, David Calvet, Ashkan Shoamanesh, for the International META-MICROBLEEDS Initiative Tags: Response to Letter to the Editor Source Type: research

Meta-analysis methodology in the field of cerebral microbleeds: The relevance of the clinical question and study quality in choosing the most appropriate model
We appreciate Singh et al. interest in our recent meta-analysis and decision schema for ischaemic stroke patients with atrial fibrillation in the presence of cerebral microbleeds [1], and thank them for the insightful comments. The overall aim of our paper was to summarise all available data from cohort studies on the topic, generate estimates from a preliminary aggregate-level meta-analysis on the association between cerebral microbleeds presence and risk of future intracererbral haemorrhage in this setting, and finally use these data to propose a practical decision algorithm in the field.
Source: Journal of the Neurological Sciences - September 18, 2017 Category: Neurology Authors: Andreas Charidimou, Gregoire Boulouis, Sara Shams, David Calvet, Ashkan Shoamanesh, for the International META-MICROBLEEDS Initiative Tags: Response to Letter to the Editor Source Type: research

Intranasal deferoxamine affects memory loss, oxidation, and the insulin pathway in the streptozotocin rat model of Alzheimer's disease
In this study, we determine whether intranasally (IN) administered DFO is beneficial in the intracerebroventricular streptozotocin (ICV STZ) rat model of sporadic Alzheimer's disease, which is different from previous models in that it exhibits dysregulation of insulin metabolism as well as oxidative stress and inflammation.
Source: Journal of the Neurological Sciences - July 20, 2017 Category: Neurology Authors: J.M. Fine, A.C. Forsberg, B.M. Stroebel, K.A. Faltesek, D.R. Verden, K.A. Hamel, E.B. Raney, J.M. Crow, L.R. Haase, K.E. Knutzen, K.D. Kaczmarczek, W.H. Frey, L.R. Hanson Source Type: research

Association between leukoaraiosis and hemorrhagic transformation after cardioembolic stroke due to atrial fibrillation and/or rheumatic heart disease
Cardioembolic stroke due to atrial fibrillation (AF) and/or rheumatic heart disease (RHD) often involves hemorrhagic transformation (HT), and we examined whether leukoaraiosis (LA) was associated with HT in these cases. We prospectively enrolled 251 patients who were admitted to two hospitals within one month of experiencing cardioembolic stroke due to AF/RHD. LA severity was assessed using three visual rating scales. HT was identified in 99 patients (39.4%) based on baseline computed tomography (CT) and post-admission magnetic resonance imaging or second CT.
Source: Journal of the Neurological Sciences - May 2, 2017 Category: Neurology Authors: Chen-Chen Wei, Shu-Ting Zhang, Yun-Han Wang, Jun-Feng Liu, Jie Li, Ruo-Zhen Yuan, Ge Tan, Shi-Hong Zhang, Ming Liu Source Type: research

Intracerebral haemorrhage risk in microbleed-positive ischaemic stroke patients with atrial fibrillation: Preliminary meta-analysis of cohorts and anticoagulation decision schema
Whether ischaemic stroke patients with atrial fibrillation (AF) and cerebral microbleeds (CMBs) on MRI can be safely anticoagulated is a hotly debated topic. We performed a systematic review and meta-analysis of published aggregate data, to investigate the risk of subsequent intracerebral haemorrhage (ICH) based on CMBs presence in this stroke population, generally considered for oral anticoagulation. We also suggest a decision-making schema for anticoagulation use in this setting.
Source: Journal of the Neurological Sciences - April 28, 2017 Category: Neurology Authors: Andreas Charidimou, Gregoire Boulouis, Sara Shams, David Calvet, Ashkan Shoamanesh, for the International META-MICROBLEEDS Initiative Source Type: research

Risk assessment of cerebral microbleeds and white matter hyperintensities in patients with non-valvular atrial fibrillation
Charidimou et al. conducted a prospective study to investigate the effect of cerebral microbleeds (CMBs) and white matter hyperintensities (WMH) on subsequent stroke in 119 patients with non-valvular atrial fibrillation [1]. The authors used multivariable Cox regression analyses. CMBs were found in 26 patients and moderate to severe WMH were found in 27 patients. During a median follow-up time of 17months, 14 patients experienced an ischemic stroke and 3 patients experienced intracerebral hemorrhage.
Source: Journal of the Neurological Sciences - January 5, 2017 Category: Neurology Authors: Tomoyuki Kawada Tags: Letter to the Editor Source Type: research

Hemorrhagic transformation and cerebral edema in acute ischemic stroke: Link to cerebral autoregulation
We examined the relationship between dynamic cerebral autoregulation (CA) in the early hours post ischemia, and the risk of developing hemorrhagic transformation and cerebral edema at 24h post stroke
Source: Journal of the Neurological Sciences - November 28, 2016 Category: Neurology Authors: Pedro Castro, Elsa Azevedo, Jorge Serrador, Isabel Rocha, Farzaneh Sorond Source Type: research

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