Intranasal deferoxamine affects memory loss, oxidation, and the insulin pathway in the streptozotocin rat model of Alzheimer's disease

In this study, we determine whether intranasally (IN) administered DFO is beneficial in the intracerebroventricular streptozotocin (ICV STZ) rat model of sporadic Alzheimer's disease, which is different from previous models in that it exhibits dysregulation of insulin metabolism as well as oxidative stress and inflammation.

Source: Journal of the Neurological Sciences - July 20, 2017 Category: Neurology Authors: J.M. Fine, A.C. Forsberg, B.M. Stroebel, K.A. Faltesek, D.R. Verden, K.A. Hamel, E.B. Raney, J.M. Crow, L.R. Haase, K.E. Knutzen, K.D. Kaczmarczek, W.H. Frey, L.R. Hanson Source Type: research