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News at a glance: A win for obesity drugs, NIH unionization roadblocks, and Mexican fireflies under threat
CONSERVATION Researchers raise alarm over threat to Mexican fireflies Scientists from the International Union for Conservation of Nature (IUCN) last week delivered a letter to the Mexican government requesting it regulate tourism centered on the threatened firefly species Photinus palaciosi . Endemic to Mexico’s Tlaxcala forests, P. palaciosi is one of the few species that glow in synchrony, offering an annual spectacle that attracts thousands of visitors during summer mating season. The letter describes how littering, artificial light, and noise interfere with the insects’ courtship and eg...
Source: ScienceNOW - August 10, 2023 Category: Science Source Type: news

News at a glance: A win for obesity drugs, a new infectious disease institute head, and Mexican fireflies under threat
CONSERVATION Researchers raise alarm over threat to Mexican fireflies Scientists from the International Union for Conservation of Nature (IUCN) last week delivered a letter to the Mexican government requesting it regulate tourism centered on the threatened firefly species Photinus palaciosi . Endemic to Mexico’s Tlaxcala forests, P. palaciosi is one of the few species that glow in synchrony, offering an annual spectacle that attracts thousands of visitors during summer mating season. The letter describes how littering, artificial light, and noise interfere with the insects’ courtship and eg...
Source: Science of Aging Knowledge Environment - August 10, 2023 Category: Geriatrics Source Type: research

Intracerebral hemorrhage and absence of pneumonia are independent predictors for nasogastric tube removal of post-stroke dysphagia
Zi Ke, Wei Liu, Fu-Yan Chen, Wen-Yi Ge, Xing-Ping Li, Xiao-Nong Fan, Bang-Qi WuAnnals of Indian Academy of Neurology 2023 26(1):90-93
Source: Annals of Indian Academy of Neurology - January 25, 2023 Category: Neurology Authors: Zi Ke Wei Liu Fu-Yan Chen Wen-Yi Ge Xing-Ping Li Xiao-Nong Fan Bang-Qi Wu Source Type: research

Safety of recanalization therapy in acute ischemic stroke patients on direct oral anticoagulant therapy: An updated systematic review and meta-analysis
Yanxing Zhang, Huan Tang, Xiaohong Gui, Ye Du, Chenglong WuAnnals of Indian Academy of Neurology 2022 25(6):1036-1046 This review provides an updated assessment of the safety of recanalization therapy for Acute Ischemic Stroke (AIS) patients receiving direct oral anticoagulants (DOAC) therapy. We checked the literature for published observational from 1st January 1950 to 31st March 2021. The rate of symptomatic intracerebral hemorrhage (sICH), arterial recanalization rate, good functional recovery, and mortality at 3 months were investigated, and data were expressed as Risk ratio (RR) with a 95% confidence inte...
Source: Annals of Indian Academy of Neurology - December 3, 2022 Category: Neurology Authors: Yanxing Zhang Huan Tang Xiaohong Gui Ye Du Chenglong Wu Source Type: research

Comparing bridging thrombolysis with direct thrombectomy in stroke due to large vessel occlusion- Indian Experience (LVO-Direct)
Conclusion: Direct thrombectomy has comparable outcomes to bridging thrombolysis in emergent large vessel occlusions.
Source: Annals of Indian Academy of Neurology - October 31, 2022 Category: Neurology Authors: Chintan Prajapati Vikram Huded Niranjan Mahajan Anirudh Kulkarni Delitia Manual Source Type: research

Tenecteplase and alteplase for thrombolysis of acute ischemic stroke within 4.5 hours: An efficacy and safety study
Conclusions: This study showed a comparable efficacy and safety profile of alteplase and TNK in thrombolysis of AIS throughout the 4.5 hours window period. Moreover, the ease of administration and better pharmacodynamic properties favors tenecteplase.
Source: Annals of Indian Academy of Neurology - October 31, 2022 Category: Neurology Authors: Nikita Dhar Mritunjai Kumar Ashutosh Tiwari Ishita Desai Govind Madhaw Niraj Kumar Source Type: research

Predictors of early neurological deterioration following intravenous thrombolysis: Difference between risk factors for ischemic and hemorrhagic worsening
Conclusion: END occurs in one fifth of patients after intravenous thrombolysis; ENDi outnumbers ENDh. Proximal artery occlusion is a major predictor for END. Potentially modifiable risk factors include admission hyperglycemia and elevated blood pressures. Distinct factors characterize ENDh and ENDi and can guide prevention and management strategies. IScore identifies patients at risk for END.
Source: Annals of Indian Academy of Neurology - September 9, 2022 Category: Neurology Authors: Srikumar B Nair Deepthi Somarajan Rammohan K Pillai Keerthi Balachandran Sona Sathian Source Type: research

Air pollution and cerebrovascular disorders with special reference to Asia: An overview
Conclusion: Even though air pollution poses a significant threat to human health, a great number of countries still fail to achieve internationally agreed air quality standards. Air pollution should be recognized among the most significant controllable risk factors for cardiovascular and cerebrovascular disease prevention and treatment.
Source: Annals of Indian Academy of Neurology - September 7, 2022 Category: Neurology Authors: Bushra Taimuri Sohail Lakhani Maryam Javed Divyani Garg Vasundhara Aggarwal Man Mohan Mehndiratta Mohammad Wasay Source Type: research

The impact of time to reperfusion on recanalization rates and outcome after mechanical thrombectomy: A single center experience
Conclusions: The recanalization rates were similar in patients irrespective of the time to reperfusion from stroke onset. The functional outcome was not inferior in late presenters selected by advanced imaging.
Source: Annals of Indian Academy of Neurology - May 25, 2022 Category: Neurology Authors: Sapna Erat Sreedharan K Arun Santhosh Kannath ER Jayadevan Jissa V Thulaseedharan PN Sylaja Source Type: research

Rescue strategies in anterior circulation stroke with failed mechanical thrombectomy & #8212;A retrospective observational study (RAFT)
Conclusions: Rescue stenting and/or angioplasty after failed MT is a safe and effective recanalization method for AIS in anterior circulation without increasing mortality or morbidity.
Source: Annals of Indian Academy of Neurology - December 17, 2021 Category: Neurology Authors: Amit Ashok Bhatti Niranjan P Mahajan Devashish Dhiren Vyas Mudasir Mushtaq Shah Vikram Huded Source Type: research

Neurological manifestations of dengue fever
Conclusions: In this study of patients admitted with dengue, neurological complications due to dengue were seen in 2.64%. Encephalopathy, encephalitis and syncope were the commonest manifestations, followed by acute symptomatic seizures, intracranial haemorrhage and GBS. The entire neuroaxis can be involved in dengue infection. To the best of our knowledge, this is the largest reported study of neurological complications of dengue.
Source: Annals of Indian Academy of Neurology - December 4, 2021 Category: Neurology Authors: Rahul Kulkarni Shripad Pujari Dulari Gupta Source Type: research

& #8216;More than just skin in the game & #8217;. DADA2 autoinflammatory syndrome and stroke in the young
Ashin Varghese, Joe Thomas, Boby Varkey MaramattomAnnals of Indian Academy of Neurology 2021 24(3):410-412 A 21-year-old man had a long-standing history of leg ulcers and hyperpigmention over the feet. Over a span of 8 months, he had an acute ischemic stroke followed by a basal ganglia hemorrhage. He was finally diagnosed with DADA2 syndrome after genetic sequencing. The implications of this new syndrome and its links to stroke in the young are presented in this article.
Source: Annals of Indian Academy of Neurology - July 17, 2021 Category: Neurology Authors: Ashin Varghese Joe Thomas Boby Varkey Maramattom Source Type: research

Do imaging markers of cerebral small vessel disease predict hematoma volume and outcome in acute intracerebral hemorrhage ?
Conclusions: WMHL in MRI serves as a predictor of hematoma expansion, a large volume bleed, and poor outcome in hypertensive ICH and may be incorporated into existing prediction models.
Source: Annals of Indian Academy of Neurology - April 28, 2021 Category: Neurology Authors: Anand R Warrier Rohit Bhatia Ajay Garg MV Padma Srivastava Deepa Dash Manjari Tripathi Mamta Bhushan Singh Vishwajeet Singh Sreenivas Vishnubhatla Kameshwar Prasad Source Type: research

Risk and prognostic factors in perinatal hemorrhagic stroke
Conclusion: Our findings showed that PHS was much more common in preterm infants. Mucosal bleeding and multiple lobes involvement were more common in term infants. PHS has high morbidity and mortality rates. Small for gestational age and mucosal bleeding were more common in infants who are dead.
Source: Annals of Indian Academy of Neurology - April 28, 2021 Category: Neurology Authors: H ü seyin Ç aksen Fatma Tuba K ö seoglu Ahmet Sami G ü ven H ü seyin Altunhan Mehmet Sinan Iyisoy Saim A ç ikg ö zoglu Source Type: research

Status epilepticus in neonates and infants
Rajni Farmania, Divyani Garg, Suvasini SharmaAnnals of Indian Academy of Neurology 2020 23(6):747-754 Status epilepticus (SE) is a common neurological emergency in childhood associated with high mortality and morbidity. Acute management of seizures along with aggressive evaluation for establishing the underlying cause are crucial determinants of outcome. Neonatal status epilepticus carries the burden of poor neurological outcomes and may lead to global developmental delay as well as persistent seizures. The aetiology and pathophysiological mechanisms of SE in neonates and young infants differ compared to older children an...
Source: Annals of Indian Academy of Neurology - December 18, 2020 Category: Neurology Authors: Rajni Farmania Divyani Garg Suvasini Sharma Source Type: research

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