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The Development of Neuroimaging Biomarkers for Cognitive Decline in Sickle Cell Disease
Sickle cell disease (SCD) is complicated by neurologic complications including vasculopathy, hemorrhagic or ischemic overt stroke, silent cerebral infarcts and cognitive dysfunction. Patients with SCD, even in the absence of vasculopathy or stroke, have experience cognitive dysfunction that progresses with age. Transcranial Doppler ultrasound and structural brain MRI are currently used for primary and secondary stroke prevention, but laboratory or imaging biomarkers do not currently exist that are specific to the risk of cognitive dysfunction in patients with SCD. Recent investigations have used advanced MR sequences asses...
Source: Hematology/Oncology Clinics of North America - November 16, 2022 Category: Cancer & Oncology Authors: Kristie Ramos, Kristin P. Guilliams, Melanie E. Fields Source Type: research

Assessing radiation-induced carotid vasculopathy using ultrasound after unilateral irradiation: a cross-sectional study
CONCLUSIONS: Increased CCA-IMT and SWV in some segments were seen in irradiated carotids. These alterations, even in young patients, mark the need for surveillance of radiation-induced vasculopathy.TRIAL REGISTRATION: clinicaltrials.gov ( https://clinicaltrials.gov/ct2/show/NCT04257968 ).PMID:35871069 | DOI:10.1186/s13014-022-02101-7
Source: Cancer Control - July 23, 2022 Category: Cancer & Oncology Authors: Judith T Pruijssen Joyce Wilbers Frederick J A Meijer Sjoert A H Pegge Jacqueline J Loonen Chris L de Korte Johannes H A M Kaanders Hendrik H G Hansen Source Type: research

Interactions among variants in TXA2R, P2Y12 and GPIIIa are associated with carotid plaque vulnerability in Chinese population.
Conclusions: The rs1131882, rs2317676, and rs16863323 three-loci interactions may confer a higher risk of carotid plaque vulnerability, and might be potential markers for plaque instability. PMID: 29707133 [PubMed]
Source: Oncotarget - May 2, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research