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ASAP Effect of Tetrahedral Framework Nucleic Acids on Neurological Recovery via Ameliorating Apoptosis and Regulating the Activation and Polarization of Astrocytes in Ischemic Stroke
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.2c10364
Source: ACS Applied Materials and Interfaces - August 11, 2022 Category: Materials Science Authors: Mi Zhou, Tianxu Zhang, Xiaolin Zhang, Mei Zhang, Shaojingya Gao, Tao Zhang, Songhang Li, Xiaoxiao Cai, Jun Li, and Yunfeng Lin Source Type: research

ASAP Neutrophil-Biomimetic “Nanobuffer” for Remodeling the Microenvironment in the Infarct Core and Protecting Neurons in the Penumbra via Neutralization of Detrimental Factors to Treat Ischemic Stroke
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.2c09020
Source: ACS Applied Materials and Interfaces - June 13, 2022 Category: Materials Science Authors: Shanshan Liu, Jianpei Xu, Yipu Liu, Yang You, Laozhi Xie, Shiqiang Tong, Yu Chen, Kaifan Liang, Songlei Zhou, Fengan Li, Zhuang Tang, Ni Mei, Huiping Lu, Xiaolin Wang, Xiaoling Gao, and Jun Chen Source Type: research

Multicomponent material property characterization of atherosclerotic human carotid arteries through a Bayesian Optimization based inverse finite element approach
CONCLUSION: The developed iFEM approach combined with the inverted GP model successfully predicted component-wise material properties of intact atherosclerotic human carotids ex-vivo under physiological-like loading conditions.SIGNIFICANCE: We developed a novel iFEM framework for the nonlinear, component-wise material characterization of atherosclerotic arteries and utilized it to obtain human atherosclerotic carotid material properties. The developed iFEM framework has great potential to be advanced for patient-specific in-vivo application.PMID:34864574 | DOI:10.1016/j.jmbbm.2021.104996
Source: Journal of the Mechanical Behavior of Biomedical Materials - December 5, 2021 Category: Materials Science Authors: Su Guvenir Torun Hakki M Torun Hendrik H G Hansen Chris L de Korte Antonius F W van der Steen Frank J H Gijsen Ali C Akyildiz Source Type: research

ASAP pH-Responsive Multifunctional Theranostic Rapamycin-Loaded Nanoparticles for Imaging and Treatment of Acute Ischemic Stroke
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.1c16530
Source: ACS Applied Materials and Interfaces - November 22, 2021 Category: Materials Science Authors: Yan Cheng, Airong Cheng, Yanlong Jia, Lin Yang, Yan Ning, Liang Xu, Yazhi Zhong, Zerui Zhuang, Jitian Guan, Xiaolei Zhang, Yan Lin, Teng Zhou, Xiusong Fan, Jianwu Li, Peng Liu ⋈, Gen Yan⧓, and Renhua Wu Source Type: research

Human bone marrow-derived mesenchymal stem cells play a role as a vascular pericyte in the reconstruction of human BBB on the angiogenesis microfluidic chip
In this study, we established human BBB-like microvasculature on an angiogenesis microfluidic chip and analyzed the role of human pericytes (hPCs) and human astrocytes (hACs) on the architecture of human brain microvascular endothelial cells (hBMEC)-derived microvasculature on a chip. We found that human bone marrow mesenchymal stem cells (hBM-MSCs) play a role as perivascular pericytes in tight BBB reformation with a better vessel-constrictive capacity than that of hPCs, providing evidence of reparative stem cells on BBB repair rather than a paracrine effect. We also demonstrated that pericytes play an important role in v...
Source: Biomaterials - October 28, 2021 Category: Materials Science Authors: Sumin Kim Somin Lee Jungeun Lim Hyeri Choi Habin Kang Noo Li Jeon Youngsook Son Source Type: research

ASAP A Co-Doped Fe < sub > 3 < /sub > O < sub > 4 < /sub > Nanozyme Shows Enhanced Reactive Oxygen and Nitrogen Species Scavenging Activity and Ameliorates the Deleterious Effects of Ischemic Stroke
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.1c06449
Source: ACS Applied Materials and Interfaces - September 21, 2021 Category: Materials Science Authors: Yunsheng Liu, Xiaojun Wang, Xiangzhu Li, Shanshan Qiao, Guodong Huang, Dirk Matthias Hermann, Thorsten Roland Doeppner, Muling Zeng, Wei Liu, Gelin Xu, Lijie Ren, Yuan Zhang, Wenlan Liu, Eudald Casals, Weiping Li, and Ya-Chao Wang Source Type: research

ASAP Xenon Nanobubbles for the Image-Guided Preemptive Treatment of Acute Ischemic Stroke via Neuroprotection and Microcirculatory Restoration
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.1c06014
Source: ACS Applied Materials and Interfaces - September 8, 2021 Category: Materials Science Authors: Juan Jin, Mei Li, Jing Li, Bin Li, Lei Duan, Fang Yang, and Ning Gu Source Type: research

Nanoparticles-mediated emerging approaches for effective treatment of ischemic stroke
Biomaterials. 2021 Aug 31;277:121111. doi: 10.1016/j.biomaterials.2021.121111. Online ahead of print.ABSTRACTIschemic stroke leads to high disability and mortality. The limited delivery efficiency of most therapeutic substances is a major challenge for effective treatment of ischemic stroke. Inspired by the prominent merit of nanoscale particles in brain targeting and blood-brain barrier (BBB) penetration, various functional nanoparticles have been designed as promising drug delivery platforms that are expected to improve the therapeutic effect of ischemic stroke. Based on the complex pathological mechanisms of ischemic st...
Source: Biomaterials - September 6, 2021 Category: Materials Science Authors: Wenxiu He Zhiwen Zhang Xianyi Sha Source Type: research

Fucoidan-functionalized polysaccharide submicroparticles loaded with alteplase for efficient targeted thrombolytic therapy
Biomaterials. 2021 Aug 30;277:121102. doi: 10.1016/j.biomaterials.2021.121102. Online ahead of print.ABSTRACTIntravenous administration of fibrinolytic drugs is the standard treatment of acute thrombotic diseases. However, current fibrinolytics exhibit limited clinical efficacy because of their short plasma half-lives and might trigger hemorrhagic transformations. Therefore, it is mandatory to develop innovative nanomedicine-based solutions for more efficient and safer thrombolysis with biocompatible and biodegradable thrombus-targeted nanocarrier. Herein, fucoidan-functionalized hydrogel polysaccharide submicroparticles w...
Source: Biomaterials - September 5, 2021 Category: Materials Science Authors: Alina Zenych Charl ène Jacqmarcq Rachida Aid Louise Fournier Laura M Forero Ramirez Fr édéric Chaubet Thomas Bonnard Denis Vivien Didier Letourneur C édric Chauvierre Source Type: research

Transplantation of 3D MSC/HUVEC spheroids with neuroprotective and proangiogenic potentials ameliorates ischemic stroke brain injury
Biomaterials. 2021 Mar 24;272:120765. doi: 10.1016/j.biomaterials.2021.120765. Online ahead of print.ABSTRACTIschemic stroke, and the consequent brain cell death, is a common cause of death and disability worldwide. Current treatments that primarily aim to relieve symptoms are relatively inefficient in achieving brain tissue regeneration and functional recovery, and thus novel therapeutic options are urgently needed. Although cell-based therapies have shown promise for treating the infarcted brain, a recurring challenge is the inadequate retention and engraftment of transplanted cells at the target tissue, thereby limiting...
Source: Biomaterials - March 29, 2021 Category: Materials Science Authors: Ting-Wei Hsu Yu-Jen Lu Yu-Jie Lin Yu-Ting Huang Li-Hung Hsieh Bing-Huan Wu Yu-Chun Lin Li-Chi Chen Hsin-Wen Wang Jui-Che Chuang Yi-Qiao Fang Chieh-Cheng Huang Source Type: research

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